Relation of neutrophil/lymphocyte ratio to resistant hypertension

Dağlı, Necati; Doğdu, Orhan; Şenarslan, Ömer; Yücel, Hasan; Kaya, Hakan; Akpek, Mahmut; Eriten, Semih

doi:10.18621/eurj.2016.5000185856

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Recently, NLR, which is considered as a strong visual fi eld of infl ammation, has been shown in many studies that can be used to predict prognosis in many diseases such as cancer, cardiac, autoimmune [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. NLR is the ratio of absolute neutrophil count to the absolute lymphocyte count.…”

Section: Discussionmentioning

confidence: 99%

“…The R-Baux score has been used for many years for estimating the risk of mortality in severely burned patients [4]. In a number of recent publications, it has been stated that the NLR which is cheap and easily calculated at every center, is a strong indicator of infl ammation in many diseases such as cancer, cardiac, and autoimmune diseases, and can be used for estimating the prognosis of the patient [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. So we also aimed to reveal the relationship between mortality and NLR in cases that treated in our center.…”

Section: Introductionmentioning

confidence: 99%

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Could neutrophil-to-lymphocyte ratio be a new mortality predictor value in severe burns?

Ali¹

2019

J Surg Surgical Res

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Background: The aim of our study was to demonstrate if there is any relation between the neutrophilto-lymphocyte ratio (NLR) and mortality in severe burns. Methods: The records of 366 patients who were admitted to Intensive Care Unit of Burn Center of Derince Training and Research Hospital between January 2012 and December 2015 were evaluated retrospectively. The cases who were hospitalized in service or did not require intensive care were not included in the study. The cases were divided into two groups: ex-group (Group 1) and discharge group (Group 2). In both groups demographic information such as age, gender, burn scores, neutrophil counts and lymphocyte counts during admission to the hospital were recorded. NLR is the ratio of absolute neutrophil count to the absolute lymphocyte count. Results: NLR was 10.94±7.63 in the exitus group and 5.5±5.56 in the discharged group. NLR was increased in mortality group and this value was statistically signifi cant (p=0.00). Independent relationship between prognoses and NLR was shown with logistic regression analyses (Odds Ratio 0.895, 95% confi dence interval 0.856-0.936, p=0.00) Conclusion: NLR has increased in mortality group. Our study showed that NLR is correlated with probability of mortality after severe burn injuries. Therefore, it can be used as a cheap, easily obtained and new mortality predictor in severe burns.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Could neutrophil-to-lymphocyte ratio be a new mortality predictor value in severe burns?

Ali¹

2019

J Surg Surgical Res

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“…Neutrophil lymphocyte ratio is an inflammatory marker, which has strong independent association with the severity of hypertension ( 90 – 93 ). During inflammation, neutrophils are the first cells to arrive at the injured site, ready to orchestrate the repair of tissue damage induced by macrophages.…”

Section: Possible Mechanisms Whereby the Crosstalk Between O-glcnacyl...mentioning

confidence: 99%

O-Linked β-N-Acetylglucosamine Modification: Linking Hypertension and the Immune System

et al. 2022

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The O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) of proteins dynamically regulates protein function, localization, stability, and interactions. This post-translational modification is intimately linked to cardiovascular disease, including hypertension. An increasing number of studies suggest that components of innate and adaptive immunity, active players in the pathophysiology of hypertension, are targets for O-GlcNAcylation. In this review, we highlight the potential roles of O-GlcNAcylation in the immune system and discuss how those immune targets of O-GlcNAcylation may contribute to arterial hypertension.

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“…However, its prognostic significance is controversial when compared to healthy subjects [5,6]. Isolated OHT is associated with structural cardiac abnormalities, and increased left ventricular mass, a well-known cardiovascular risk marker, is one of these abnormalities [7][8][9][10].…”

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confidence: 99%

Pulse Wave Velocity is an Independent Predictor of Office Hypertension

Şahin¹,

Şatıroğlu²,

Duman³

et al. 2021

Int J Clin Cardiol

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Aim: Carotid-femoral pulse wave velocity (cf-PWV) is the gold standard measure of arterial stiffness and a stronger predictor of poor outcomes for cardiovascular events. Pulse wave velocity is closely related to blood pressure, but its effect on office hypertension (OHT) is unclear. The study aims to investigate the relationship between OHT and cf-PWV. Materials and methods:This was a prospective, singlecenter, clinical trial. A total of 102 subjects were included in the study: 48 patients with OHT and 54 subjects with normal blood pressure. Clinical risk factors and biochemical parameters were noted. Subjects underwent an assessment of cf-PWV by the validated tonometric system (SphygmoCor). The healthy group and the OHT group were compared.Results: Demographic and clinical parameters did not differ between groups. However, cf-PWV values were higher in the OHT group compared to healthy subjects. (9.0 ± 1.7 m/s vs. 7.9 ± 1.8 m/s, p = 0.002). The cf-PWV was correlated with systolic blood pressure, (r = 0.310, p = 0.002), and found as an independent predictor of OHT. ROC analysis identified that PWV levels had moderate sensitivity and specificity for predicting OHT. Conclusion:The patients with OHT have higher cf-PWV values compared to healthy subjects. Pulse wave velocity plays a role in the pathophysiology of OHT, and is an independent predictor of it.

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Relation of neutrophil/lymphocyte ratio to resistant hypertension

Cited by 5 publications

References 24 publications

Could neutrophil-to-lymphocyte ratio be a new mortality predictor value in severe burns?

Could neutrophil-to-lymphocyte ratio be a new mortality predictor value in severe burns?

O-Linked β-N-Acetylglucosamine Modification: Linking Hypertension and the Immune System

Pulse Wave Velocity is an Independent Predictor of Office Hypertension

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