Relation of Occupational Exposure to Respiratory Symptoms and Asthma in a General Population Sample: Self-reported versus Interview-based Exposure Data

Bakke, Per; Hanoa, Rolf; Gulsvik, Amund

doi:10.1093/aje/154.5.477

Cited by 35 publications

(36 citation statements)

References 26 publications

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“…BAKKE et al [25] have shown that more specific outcome items, such as physician diagnosed-asthma, are less associated with bias of the reporting of exposure, as compared with less sensitive items, such as symptom-based questions. In the present study similar trends were found with increased reporting of exposure with increasing prevalence of both symptoms and physician-diagnosed asthma.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of asthma and exhaled nitric oxide are increased in bleachery workers exposed to ozone

Olin¹,

Andersson²,

Andersson³

et al. 2003

Eur Respir J

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The aims of the present study were to determine whether exposure to high peaks of ozone resulted in an increased prevalence of asthma or respiratory symptoms among bleachery workers and whether nitric oxide (NO) was elevated in the exhaled air of these workers.Bleachery workers (n=228) from three Swedish pulp mills who had been exposed to ozone, together with 63 unexposed control subjects, were investigated by means of spirometry, Phadiatop1, exhaled and nasal NO and answers to a questionnaire concerning respiratory symptoms and exposure. Exposure to an ozone peak that gave rise to respiratory symptoms was defined as a "gassing".Bleachery workers reporting four or more gassings involving ozone had an increased prevalence of adult-onset asthma, wheeze, and current asthma symptoms. They also had a higher median concentration of exhaled NO in comparison with those who reported no such gassings (19.2 versus 15.7 parts per billion). No such associations were found in respect of nasal NO.The results from this study show that bleachery workers who have been repeatedly exposed to ozone gassings have an increased prevalence of adult-onset asthma. The results also indicate exhaled nitric oxide may be a marker of airway inflammation in bleachery workers who have been exposed to high peaks of ozone.

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Section: Discussionmentioning

confidence: 99%

Prevalence of asthma and exhaled nitric oxide are increased in bleachery workers exposed to ozone

Olin¹,

Andersson²,

Andersson³

et al. 2003

Eur Respir J

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show abstract

“…In a Norwegian study, the sensitivity of the question on exposure to dust and gas was biased by respiratory symptoms, but hardly at all by physician-diagnosed asthma [16], the outcome used in the present study. Bias is more important in sensitivity than it is in specificity for the effect of misclassification of exposure for a common exposure, such as the gassings in the present study [17].…”

Section: Asthma Irritants and Gases E Andersson Et Almentioning

confidence: 97%

Incidence of asthma among workers exposed to sulphur dioxide and other irritant gases

Andersson

Knutsson²,

Hagberg³

et al. 2006

Eur Respir J

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The aim of the present study was to investigate whether repeated peak exposure (gassings) to sulphur dioxide (SO 2 ) and other irritant gases increases the risk of new-onset asthma. A questionnaire was sent to 4,112 sulphite workers, of whom 1,919 completed the questionnaire and 396 completed the short-form questionnaire, which was sent out as a last reminder. A sample of 130 nonrespondents completed a telephone interview using the short-form questionnaire.The incidence of adult-onset, physician-diagnosed asthma during employment duration was analysed in relation to exposure to SO 2 and gassings giving rise to respiratory symptoms. Incidence rates, as well as incidence rate ratios with 95% confidence interval (CI), were calculated. Further Cox regression models were used allowing assessment of hazard ratios (HR) stratified for sex and adjusted for atopy, smoking habits and age.The incidence rate for asthma among sulphite mill workers reporting gassings of SO 2 was 6.2 out of 1,000 person-yrs, compared with 1.9 out of 1,000 person-yrs among subjects unexposed to SO 2 and any gassings (HR (95% CI) 4.0 (2.1-7.7)). Among males reporting gassings to SO 2 , the HR (95% CI) for asthma was 5.8 (2.6-13) compared with unexposed males.In conclusion, repeated peak exposure to sulphur dioxide increased the incidence of asthma during work in sulphite pulp mills, which supports the hypothesis of irritant-induced asthma.

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“…It could be that the validity of the self-reported exposure to various agents is higher for women than men (18). However, the JEM-based exposure characterization is less subject to recall bias than the self-reported exposure characterization (6,19,20).…”

Section: Skorge Et Almentioning

confidence: 99%

Occupational exposure and incidence of respiratory disorders in a general population

Skorge¹,

Eagan²,

Eide³

et al. 2009

Scand J Work Environ Health

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Relation of Occupational Exposure to Respiratory Symptoms and Asthma in a General Population Sample: Self-reported versus Interview-based Exposure Data

Cited by 35 publications

References 26 publications

Prevalence of asthma and exhaled nitric oxide are increased in bleachery workers exposed to ozone

Prevalence of asthma and exhaled nitric oxide are increased in bleachery workers exposed to ozone

Incidence of asthma among workers exposed to sulphur dioxide and other irritant gases

Occupational exposure and incidence of respiratory disorders in a general population

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