Relation of perceived nasal and bronchial hyperresponsiveness to FEV1, basophil counts, and methacholine response.

Kauffmann, F.; Neukirch, Françoise; Annesi, I; Korobaeff, M; Doré, Marie-France; Lellouch, J

doi:10.1136/thx.43.6.456

Cited by 27 publications

(17 citation statements)

References 17 publications

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“…For example, the percentage of leukocytes in the blood is altered as a result of smoking, by the time of day and during menstruation (Kauffmann et al, 1988). We detected the baseline immune parameters in heatstressed pigs in earlier studies, such as the number of WBC and cell differential counts by using the Neubauer chamber method (Ju et al, 2011a).…”

Section: Discussionmentioning

confidence: 78%

Heat stress upregulation of Toll-like receptors 2/4 and acute inflammatory cytokines in peripheral blood mononuclear cell (PBMC) of Bama miniature pigs: an in vivo and in vitro study

Yong

et al. 2014

Animal

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Global warming is a challenge to animal health, because of increased heat stress, with subsequent induction of immunosuppression and increased susceptibility to disease. Toll-like receptors (TLR) are pattern recognition receptors that act as sentinels of pathogen invasion and tissue damage. Ligation of TLRs results in a signaling cascade and production of inflammatory cytokines, which eradicate pathogens and maintain the health of the host. We hypothesized that the TLR signaling pathway plays a role in immunosuppression in heat-stressed pigs. We explored the changes in the expression of TLR2, TLR4 and the concentration of acute inflammatory cytokines, such as IL-2, IL-8, IL-12 and IFN-γ in Bama miniature pigs subjected to 21 consecutive days of heat stress, both in vitro and in vivo models. The results showed that heat stress induced the upregulation of cortisol in the plasma of pigs (P < 0.05); TLR4 mRNA was elevated, but IL-2 was reduced in peripheral blood mononuclear cells (PBMC, P < 0.05). The white blood cell count and the percentage of granulocytes (eosinophilic + basophilic) decreased significantly in heat-stressed pigs (P < 0.05). In the in vitro model (PBMC heat shocked for 1 h followed by a 9 h recovery period), TLR2 and TLR4 mRNA expression also increased, as did the concentration of IL-12 in supernatants. However, IFN-γ was significantly reduced in PBMC culture supernatants (P < 0.05). We concluded that a consecutive heat stress period elevated the expression of TLR2 and TLR4 in PBMC and increased the plasma levels of inflammatory cytokines. These data indicate that TLR activation and dysregulation of cytokine expression in response to prolonged heat stress may be associated with immunosuppression and increased susceptibility to antigenic challenge in Bama miniature pigs.

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Section: Discussionmentioning

confidence: 78%

Heat stress upregulation of Toll-like receptors 2/4 and acute inflammatory cytokines in peripheral blood mononuclear cell (PBMC) of Bama miniature pigs: an in vivo and in vitro study

Yong

et al. 2014

Animal

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“…In addition, an increased peripheral-blood eosinophil count is significantly associated with nonspecific airway hyperresponsiveness in asthmatic subjects [21]. Several studies have shown that high peripheral-blood eosinophil counts are associated with chronic respiratory symptoms (asthma, persistent wheeze, dyspnoea, chronic cough and phlegm) [19,[22][23][24][25][26]. The identification of eosinophilia as an independent risk factor for symptoms of cough and phlegm [23] and asthma [26] also suggests a role for eosinophils in the pathogenesis of COLD [26,27].…”

Section: Discussionmentioning

confidence: 99%

Chronic respiratory symptoms and airway responsiveness to methacholine are associated with eosinophilia in older men: the Normative Aging Study

Annema¹,

Sparrow²,

O’Connor³

et al. 1995

Eur Respir J

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C Ch hr ro on ni ic c r re es sp pi ir ra at to or ry y s sy ym mp pt to om ms s a an nd d a ai ir rw wa ay y r re es sp po on ns si iv ve en ne es ss s t to o m me et th ha ac ch ho ol li in ne e a ar re e a as ss so oc ci ia at te ed d w wi it th h e eo os si in no op ph hi il li ia a i in n o ol ld de er r m me en n: : T Th he e N No or rm ma at ti iv ve e A Ag gi in ng g S St tu ud dy y ABSTRACT: Identification of subsets of patients with chronic obstructive lung disease (COLD) in order to determine disease outcomes and, possibly, the effects of treatment is an area of clinical interest. At present, it remains unclear which patients with COLD are most likely to benefit from anti-inflammatory therapy. We investigated this question in a community-dwelling sample of men. In this study, the relationship of chronic respiratory symptoms, airway responsiveness to methacholine, and skin test reactivity to peripheral-blood eosinophil and neutrophil counts was examined among 894 male participants in the Normative Aging Study (mean age 60 yrs; range 41-90 yrs). The symptoms considered were asthma, persistent wheeze, dyspnoea, chronic cough and phlegm. Responsiveness to methacholine was defined as a provocative dose producing a 20% fall in forced expiratory volume in one second (PD 20 FEV 1 ) of ≤8.6 µmol, a positive skin test as a wheal diameter of ≥5 mm after subtraction of the diameter of any wheal reaction to a glycerin control, and eosinophilia as an eosinophil count of ≥275 cells·mm -3 in peripheral blood.Chronic symptoms (odds ratio (OR) 2.0; 95% confidence interval (CI) 1.4-2.7), airway responsiveness (OR 1.7; CI 1.1-2.7), and the combination of symptoms and airway responsiveness (OR 3.4; CI 2.0-5.6) were positively and significantly related to peripheral-blood eosinophil counts. These relationships remained significant after adjustment for the effects of age and smoking, and after exclusion of asthmatic subjects. Symptoms and airway responsiveness combined were not significantly related to neutrophil counts.These data suggest that increased airway responsiveness to methacholine is associated with elevated peripheral-blood eosinophil counts in subjects with chronic respiratory symptoms. Asymptomatic subjects with increased airway responsiveness also have increases in peripheral-blood eosinophil counts.

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“…As a part o f an ongoing study started in 1980/81 on the risk factors for chronic airflow limitations [9], 599 men working in the Parisian Police aged 28-58 years were selected in 1985/86 from the initial pop ulation to participate in a follow-up including also as a specific ob jective a prospective investigation o f UAD. The selected sample com prised: (i) 306 men with a previous history of asthma, wheezing, any perceived bronchial or nasal hyperresponsiveness (such as sneezes or runny nose or fit of coughing provoked by cold air and smoke), ec zema.…”

Section: Study Populationmentioning

confidence: 99%

Relationship of Upper Airway Disease to Tobacco Smoking and Allergic Markers: A Cohort Study of Men Followed Up for 5 Years

Annesi‐Maesano¹,

Oryszczyn²,

Neukirch³

et al. 1997

Int Arch Allergy Immunol

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Data derived from a cohort study of 191 men, seen 5 years apart, were used to investigate the involvement in allergic as well as in nonallergic upper airway disease (UAD) of two risk factors, immediate hypersensitivity and tobacco smoking, the roles of which have been well established in lower airway disease. At both surveys, UAD and smoking habits were assessed by an extended version of the BMRC/ECSC questionnaire. UAD consisted of usual or chronic rhinitis, seasonal allergic rhinitis and perceived nasal hyperresponsiveness (PNHR) to tobacco smoke, cold air or exercise. Immediate hypersensitivity was determined either in vivo (skin prick test, SPT, positivity) or in vitro (total IgE). UAD prevalence and smoking habits did not vary significantly over 5 years. On the contrary, SPT positivity increased significantly between the two surveys. At both surveys, SPT positivity for common aeroallergens (grass pollens overall) was significantly related to seasonal allergic rhinitis but not to usual or chronic rhinitis and to PNHR. Similarly, the total IgE level was increased in seasonal allergic rhinitis, but never significantly. Current smoking was always a habit significantly more frequent in men reporting chronic rhinitis (odds ratios of 5.3 and 4.9 in 1985 and 1990, respectively). The relationship was of the dose-response type: the more the subjects smoked, the more they reported chronic rhinitis. In contrast, seasonal allergic rhinitis was more associated with exsmoking, either in 1985 or in 1990. These results were confirmed longitudinally and after exclusion of asthmatics. Further investigations are needed to support the hypothesis raised by our data according to which immediate hypersensitivity, as assessed by SPT positivity for common aeroallergens, and tobacco smoking might intervene alternatively in UAD, probably because of the ‘healthy smoker effect’.

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Relation of perceived nasal and bronchial hyperresponsiveness to FEV1, basophil counts, and methacholine response.

Cited by 27 publications

References 17 publications

Heat stress upregulation of Toll-like receptors 2/4 and acute inflammatory cytokines in peripheral blood mononuclear cell (PBMC) of Bama miniature pigs: an in vivo and in vitro study

Heat stress upregulation of Toll-like receptors 2/4 and acute inflammatory cytokines in peripheral blood mononuclear cell (PBMC) of Bama miniature pigs: an in vivo and in vitro study

Chronic respiratory symptoms and airway responsiveness to methacholine are associated with eosinophilia in older men: the Normative Aging Study

Relationship of Upper Airway Disease to Tobacco Smoking and Allergic Markers: A Cohort Study of Men Followed Up for 5 Years

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