Relation of Porphyrin Content to Red Cell Age: Analysis by Fractional Hemolysis

Johnson, LaRue W.; Schwartz, Samuel

doi:10.3181/00379727-139-36107

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…Metabolism of porphyrins was the most significant disturbed pathway and changed in 88.0% SCD subjects. It is well known that hemolysis of red blood cells is an inherent characteristic associated with SCD, and results in the release of porphyrins and its metabolites [25,26]. Porphyrins comprise a portion of hemoglobin, the major constituent of human red blood cells.…”

Section: Discussionmentioning

confidence: 99%

Individualized identification of disturbed pathways in sickle cell disease

Wang

Huang

et al. 2017

Open Life Sciences

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Abstract:Background: Sickle cell disease (SCD) is one of the most common genetic blood disorders. Identifying pathway aberrance in an individual SCD contributes to the understanding of disease pathogenesis and the promotion of personalized therapy. Here we proposed an individualized pathway aberrance method to identify the disturbed pathways in SCD. Methods: Based on the transcriptome data and pathway data, an individualized pathway aberrance method was implemented to identify the altered pathways in SCD, which contained four steps: data preprocessing, gene-level statistics, pathway-level statistics, and significant analysis. The changed percentage of altered pathways in SCD individuals was calculated, and a differentially expressed gene (DEG)-based pathway enrichment analysis was performed to validate the results. Results: We identified 618 disturbed pathways between normal and SCD conditions. Among them, 6 pathways were altered in > 80% SCD individuals. Meanwhile, forty-six DEGs were identified between normal and SCD conditions, and were enriched in heme biosynthesis. Relative to DEGbased pathway analysis, the new method presented richer results and more extensive application. Conclusion: This study predicted several disturbed pathways via detecting pathway aberrance on a personalized basis. The results might provide new sights into the pathogenesis of SCD and facilitate the application of custom treatment for SCD.

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Section: Discussionmentioning

confidence: 99%

Individualized identification of disturbed pathways in sickle cell disease

Wang

Huang

et al. 2017

Open Life Sciences

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“…As the proportion of young red cells in the circulation rises, the blood concentration of uroporphyrin increases (28,29), because the half-time for uroporphyrin survival in red cells is very short (30). In fox squirrels, phlebotomy seems also to produce an increase in the concentration of uroporphyrin I in the spleen, presumably as a result of the destruction of rapidly-formed, short-lived red cells.…”

Section: Methodsmentioning

confidence: 99%