Relation of protein energy wasting to carotid intima media thickness in hemodialysis patients

Mahmoud, Mostafa; Nagy, Eman; Abdalbary, Mohamed; El-Kannishy, Ghada; Sayed‐Ahmed, Nagy

doi:10.1038/s41371-020-0376-7

Cited by 9 publications

(9 citation statements)

References 18 publications

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“…The current findings are in line with lietarture 27 , and suggest that patients on haemodialysis are subjected to OS that leads to the formation of oxidised low-density lipoprotein (LDL) and generation of inflammatory mediators that lead to the development of atherosclerotic heart disease.…”

Section: Discussionsupporting

confidence: 81%

Correlation between Serum Malondialdehyde levels and prevalence of cardiovascular disease in Haemodialysis treated patients

2022

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Objectives: To investigate the role of serum malondialdehyde as a diagnostic biomarker of free radical production and cardiovascular disease in patients treated with maintenance haemodialysis. Method: The case-control study was conducted in the Department of Biochemistry, Basic Medical Sciences Institute (BMSI) of the Jinnah Postgraduate Medical Centre (JPMC), Karachi, and the JPMC Nephrology ward from January 12, 2018, to January 15, 2019, and comprised patients receiving haemodialysis as the cases and healthy controls. Blood samples were obtained from all the subjects for checking the level of serum malondialdehyde. Doppler ultrasonography was employed to detect the intima media thickness ratio of the common carotid artery of all the subjects. Data ws analysed using SPSS 23. Results: Of the 90 subjects, 45(50%) each were cases and controls. There were significant differences in mean values related to age, body mass index and blood pressure between the groups. A statistically significant rise was seen in serum malondialdehyde and carotid artery intima media thickness ratio in the cases compared to the controls (p<0.05). Conclusion: Serum malondialdehyde was found to be significantly raised in haemodialysis patients compared to the healthy controls. Key Words: Malondialdehyde, Haemodialysis, Cardiovascular disease, Oxidative stress, Free radicals.

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Section: Discussionsupporting

confidence: 81%

Correlation between Serum Malondialdehyde levels and prevalence of cardiovascular disease in Haemodialysis treated patients

2022

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“…Our results are also similar to Mahmoud et al 18 who also showed increased carotid artery IMT (1.0 ± 0.7) in hemodialysis patients. These findings suggest that patients on hemodialysis are subjected to oxidative stress that leads to the formation of oxidized LDL and generation of inflammatory mediators that lead to development of atherosclerotic heart disease.…”

Section: Discussionsupporting

confidence: 92%

Impact of Enhanced Lipid Peroxidation on Carotid Artery Intima Media Thickness Ratio in Patients Receiving Maintenance Hemodialysis

Rehman

Mahboob

Kumar

et al. 2022

PAFMJ

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Objective: To determine the impact of increased lipid peroxidation on carotid intima media thickness ratio in patients receiving maintenance hemodialysis. Study Design: Comparative prospective study. Place and Duration of Study: Jinnah Post Graduate Medical Center Karachi in collaboration with University of Karachi, Pakistan, from Jan to Dec 2018. Methodology: The hemodialysis patients were selected from the dialysis center where as the controls were recruited from normal healthy population. The cases taken were receiving maintenance hemodialysis thrice a week. Doppler ultrasonography technique was employed to detect the intima media thickness (IMT) ratio of common carotid artery of study subjects as well as controls. Lipid peroxidation was detected by serum oxidized LDL (ox-LDL) levels. Results: The mean of right common carotid artery of group A samples was 0.45 ± 0.04 mm, left common carotid artery was 0.42 ± 0.01mm, and mean intima thickness was 0.43 ± 0.02 mm, the mean of right common carotid artery in group B was 0.93 ± 0.09 mm and mean of left common carotid in group B was 1.07 ± 0.14 mm and mean intima thickness of group B samples was 1.0 ± 0.09 mm. In group A mean Ox-LDL was 24.87 ± 5.23 U/ml while in group C samples mean Ox-LDL was 73.77 ± 6.77 U/ml. Conclusion: Lipid peroxidation is much enhanced in patients on maintenance hemodialysis and leads to an increased carotid artery intima media thickness ratio which is a sign of development of atherosclerosis. This study will help the nephrologists in determining the causes..................

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“…Our results are similar to Mahmoud who also found that carotid artery intima media thickness is correlated with inflammatory processes in haemodialysis patients 25 . These findings suggest that patients on haemodialysis are subjected to oxidative stress that leads to the formation of oxidized LDL and generation of inflammatory mediators that lead to development of atherosclerotic heart disease.…”

Section: Discussionsupporting

confidence: 92%

“…These findings suggest that patients on haemodialysis are subjected to oxidative stress that leads to the formation of oxidized LDL and generation of inflammatory mediators that lead to development of atherosclerotic heart disease. The carotid artery intima media thickness ratio is a non-invasive indicator and predictor of sub clinical atherosclerotic heart disease and has been discussed in many previous studies 24,25 .…”

Section: Discussionmentioning

confidence: 99%

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Association of Elevated Oxidized Low Density Lipoprotein to Low Density Lipoprotein Ratio (Ox LDL/LDL) with Sub Clinical Atherosclerosis in Patients Receiving Maintenance Haemodialysis

Rehman

Kumar

Nisar

et al. 2022

AJSMU

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Objective: To assess the oxidized low density lipoprotein (ox-LDL) to low density lipoprotein (LDL) ratio as an indicator of subclinical atherosclerosis in haemodialysis patients Methodology: This case control study was carried out at Jinnah Post Graduate Medical Center Karachi, from January to December 2018. The haemodialysis patients were selected from the dialysis center (group B) whereas the controls were recruited from normal healthy population (group A). To access the status of atherosclerosis, doppler ultrasonography technique was employed to detect the intima media thickness (IMT) ratio of common carotid artery of study subjects as well as controls. Lipid peroxidation was detected by serum oxidized LDL (ox-LDL) levels. Results: The mean of carotid artery intima thickness in group A was 0.43±0.02, the mean intima thickness of group B samples was 1.0±0.09. The mean ratio of Ox-LDL/LDL in group A was 0.003±0.001. While in group B the mean of Ox-LDL: LDL was 0.012±0.002. Ox-LDL was found to have a positive linear relationship with mean carotid artery intima media thickness ratio (r=0.8) in haemodialysis group. Conclusion: Ox-LDL to LDL ratio is much enhanced in patients on maintenance haemodialysis showing increased lipid peroxidation. Ox-LDL has a positive linear relationship with mean carotid artery intima media thickness ratio which is a marker of sub clinical atherosclerosis. Early detection of elevated Ox-LDL will help nephrologists in early detection and treatment of sub clinical atherosclerosis.

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Relation of protein energy wasting to carotid intima media thickness in hemodialysis patients

Cited by 9 publications

References 18 publications

Correlation between Serum Malondialdehyde levels and prevalence of cardiovascular disease in Haemodialysis treated patients

Correlation between Serum Malondialdehyde levels and prevalence of cardiovascular disease in Haemodialysis treated patients

Impact of Enhanced Lipid Peroxidation on Carotid Artery Intima Media Thickness Ratio in Patients Receiving Maintenance Hemodialysis

Association of Elevated Oxidized Low Density Lipoprotein to Low Density Lipoprotein Ratio (Ox LDL/LDL) with Sub Clinical Atherosclerosis in Patients Receiving Maintenance Haemodialysis

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