Relation of salivary antioxidant status and cytokine levels to clinical parameters of oral health in pregnant women with diabetes

Surdacka, Anna; Ciężka, Edyta; Pioruńska-Stolzmann, Maria; Wender-Ożegowska, Ewa; Korybalska, Katarzyna; Kawka, Edyta; Kaczmarek, Elżbieta; Witowski, Janusz

doi:10.1016/j.archoralbio.2010.11.005

Cited by 44 publications

(34 citation statements)

References 30 publications

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“…Almost a three fold increase in catalase activity in saliva of pregnant women with diabetic complications was found compared to healthy controls but a correlation with the parameters of oral health could not be established. 37 On comparison of diabetics with CP and healthy individuals with CP, in saliva the activities of SOD and CAT were decreased while that of GR was found to be elevated. 38 It was reasoned that the capacity to detoxify oxygen radicals was diminished because of excessive oxygen radical production from auto-oxidation of glucose, glycated proteins, and glycation of antioxidant enzymes.…”

Section: Antioxidant Enzymes In Diabeticsmentioning

confidence: 99%

Antioxidant enzymes in periodontitis

Trivedi

Lal

2017

Journal of Oral Biology and Craniofacial Research

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Section: Antioxidant Enzymes In Diabeticsmentioning

confidence: 99%

Antioxidant enzymes in periodontitis

Trivedi

Lal

2017

Journal of Oral Biology and Craniofacial Research

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“…MMP-9 is a protease often found elevated in patients with periodontal disease [13] and oral cancer [14]; whereas MPO, a peroxidase often used as a measure of neutrophil degranulation, is elevated in diabetic patients [15]. Vascular endothelial growth factor (VEGF) was included because it appears in saliva of diabetic women [16]. C-reactive protein (CRP) was included because it is associated with inflammation and cardiovascular disease [17].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Disease Risk in Children by Salivary Biomarker Analysis

Goodson¹,

Kantarcı²,

Hartman³

et al. 2014

PLoS ONE

100

138

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ObjectiveThe study of obesity-related metabolic syndrome or Type 2 diabetes (T2D) in children is particularly difficult because of fear of needles. We tested a non-invasive approach to study inflammatory parameters in an at-risk population of children to provide proof-of-principle for future investigations of vulnerable subjects.Design and MethodsWe evaluated metabolic differences in 744, 11-year old children selected from underweight, normal healthy weight, overweight and obese categories by analyzing fasting saliva samples for 20 biomarkers. Saliva supernatants were obtained following centrifugation and used for analyses.ResultsSalivary C-reactive protein (CRP) was 6 times higher, salivary insulin and leptin were 3 times higher, and adiponectin was 30% lower in obese children compared to healthy normal weight children (all P<0.0001). Categorical analysis suggested that there might be three types of obesity in children. Distinctly inflammatory characteristics appeared in 76% of obese children while in 13%, salivary insulin was high but not associated with inflammatory mediators. The remaining 11% of obese children had high insulin and reduced adiponectin. Forty percent of the non-obese children were found in groups which, based on biomarker characteristics, may be at risk for becoming obese.ConclusionsSignificantly altered levels of salivary biomarkers in obese children from a high-risk population, suggest the potential for developing non-invasive screening procedures to identify T2D-vulnerable individuals and a means to test preventative strategies.

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“…Even then, the collection procedure was difficult to standardize and the saliva flow rates were impossible to calculate. Therefore, the samples were collected as is, the analysis was limited to the mediators known to be detectable in saliva [26] and their concentrations were normalized per total salivary protein contents. Nevertheless, the interpretation of the data thus obtained is challenging and may be prone to bias.…”

Section: Discussionmentioning

confidence: 99%

Oral Health Status of Patients with Lysosomal Storage Diseases in Poland

Drążewski

Grzymisławska

Korybalska

et al. 2017

IJERPH

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Patients with lysosomal storage diseases (LSDs) suffer from physical and mental disabilities, which together with poor access to professional care may lead to impaired oral health. This cross-sectional case-control study characterized the status of oral health in patients with LSDs in Poland. Thirty-six children and young adults with various forms of LSDs were examined. The data were compared with those from age- and sex-matched healthy controls. Exemplary cases were presented to highlight typical problems in oral care associated with LSDs. When possible, saliva was collected and analyzed for total protein, inflammatory mediators, and antioxidant status. Generally, patients with LSDs had significantly higher prevalence of caries, inferior gingival status, and inadequate oral hygiene. The severity of oral health impairment in mucopolysaccaridoses, the most common LSD in Poland, was similar to that seen in patients with mannosidoses or Pompe disease. Saliva could be collected only from few less handicapped patients. In MPS, it did not appear to differ significantly from the controls, but in patients with Pompe disease it contained lower concentrations of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1), but higher levels of tumor necrosis factor receptors 1 and 2 (TNF-R1, TNF-R2) and myeloperoxidase (MPO). In conclusion, Polish patients with LSDs have an inadequate level of oral hygiene and substantially deteriorated oral health.

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Relation of salivary antioxidant status and cytokine levels to clinical parameters of oral health in pregnant women with diabetes

Cited by 44 publications

References 30 publications

Antioxidant enzymes in periodontitis

Antioxidant enzymes in periodontitis

Metabolic Disease Risk in Children by Salivary Biomarker Analysis

Oral Health Status of Patients with Lysosomal Storage Diseases in Poland

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