Relation of senescence with systemic inflammation and serum paraoxanase activity: A clinical approach

Abstract

It has been documented that the incidence of inflammation along with oxidative stress in biological system leads to the development of age related complications. However, the mechanism exploring the conundrum of senescence with various sorts of health complications is still in obscure. Therefore, the present study was designed to evaluate the relation of serum paraoxonase (PON) with markers of systemic inflammation and lipid peroxidation in the blood samples of different age group subjects and to determine their relation in the prediction of cardiovascular disease risk. Marker of lipid peroxidation (malondialdehyde; MDA), serum paraoxonase, c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were estimated in selected 90 healthy subjects by using standard methods. Out of 90 subjects, 60 individuals were categorized into two groups: Group I (40-55 years) and Group II (≥ 56 years) and statistically compared it with that of 30 younger controls (20-30 years). Marked depletion in serum PON activity was observed in Group I and II as compared to healthy controls whereas erythrocyte MDA levels were increased significantly (p<0.05) in Group I and II subjects. However, serum CRP levels were increased significantly (p<0.05) only in Group II subjects whereas ESR levels were altered insignificantly (p<0.01) in Group I and II subjects as compare to controls. In addition, PON activity was inversely correlated with marker of systemic inflammation and lipid peroxidation. Thus, assessment of serum paraoxonase activity incorporation with marker of systemic inflammation is a crucial step in early diagnosis of cardiovascular complications in elderly. Therefore, regular monitoring of cardiac markers and antioxidant rich diet should be adopted with senescence.