Relation of serum calcium concentration to metabolic risk factors for cardiovascular disease.

Lind, Lars; Jakobsson, Sören; Lithell, Hans; Wengle, Bo; Ljunghall, Sverker

doi:10.1136/bmj.297.6654.960

Cited by 119 publications

(90 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings confirm previous reports, 1,5,30 but in particular, as noted by Kesteloot and Geboers, 2 they also confirm the more prominent association between blood pressure and serum calcium in younger men. Not surprisingly, associations from large populationbased studies have generally been quite weak (ro0.20), 1,4,6,31 which is possibly the result of failing to stratify by age and gender.…”

Section: Discussionsupporting

confidence: 92%

“…To add to the confusion, this association seems to be present mostly in men. 2,6 In addition, serum calcium tends to increase with age only in women, 5 while blood pressure increases with age in both genders, 7 although the increase is less pronounced in women. 8 Kesteloot and Geboers 2 also noticed that the blood pressure-serum calcium relationship was stronger in younger compared with older men.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum calcium revisited: associations with 24-h ambulatory blood pressure and cardiovascular reactivity in Africans

et al. 2010

View full text Add to dashboard Cite

Sub-Saharan Africans face an increasing burden of hypertension. Although controversial, recent experimental evidence strongly suggests that serum calcium contributes to elevated blood pressure through increased vascular resistance. We investigated the associations of 24-h blood pressure and cardiovascular reactivity with serum calcium in African men stratified by age. The study consisted of 50 younger (median age: 38 years) and 49 older (median age: 49 years) participants. We measured 24-h ambulatory blood pressure with a mean successful inflation rate of 72.6%. Total peripheral resistance and stroke volume reactivity were obtained using a Finometer device during application of the Stroop color and word conflict test. Total serum calcium was adjusted for serum albumin. Results showed that serum calcium levels were similar between the younger and older groups. However, in the younger group, 24-h systolic blood pressure, 24-h diastolic blood pressure and total peripheral resistance reactivity correlated positively, whereas stroke volume reactivity correlated negatively with serum calcium in single and multiple regression analyses (systolic blood pressure: B¼34.99, P¼0.017; diastolic blood pressure: B¼34.93, Po0.001; total peripheral resistance reactivity: B¼65.44, P¼0.048; stroke volume reactivity: B¼À45.40, P¼0.017). No associations were evident in the older African men. In conclusion, 24-h ambulatory systolic and diastolic blood pressures are positively associated with serum calcium in African men younger than 43 years. The blood pressure-serum calcium relationship seems to be mediated through increased vascular resistance during stress.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Serum calcium revisited: associations with 24-h ambulatory blood pressure and cardiovascular reactivity in Africans

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Intracellular calcium disturbances have been suggested as the factor linking the wide range of abnormalities of the metabolic syndrome, such as hypertension, insulin resistance and obesity [8,9]. A few previous epidemiological investigations have explored the associations between extracellular serum levels of calcium, insulin sensitivity and secretion [10][11][12][13]. However, previous studies have been limited by the use of surrogate markers of insulin sensitivity and secretion [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…A few previous epidemiological investigations have explored the associations between extracellular serum levels of calcium, insulin sensitivity and secretion [10][11][12][13]. However, previous studies have been limited by the use of surrogate markers of insulin sensitivity and secretion [10][11][12][13]. All previous epidemiological studies have included subjects with diabetes or IFG and IGT [10][11][12][13], making it difficult to evaluate the independent relationship of serum calcium with the underlying causes of pathologically increased levels of glucose.…”

Section: Introductionmentioning

confidence: 99%

“…All previous epidemiological studies have included subjects with diabetes or IFG and IGT [10][11][12][13], making it difficult to evaluate the independent relationship of serum calcium with the underlying causes of pathologically increased levels of glucose. Furthermore, all previous studies have included individuals with supra-and subnormal levels of calcium [10][11][12][13] and our knowledge of the relationship between serum calcium within the normal range and insulin sensitivity and secretion is limited.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum calcium is independently associated with insulin sensitivity measured with euglycaemic–hyperinsulinaemic clamp in a community-based cohort

et al. 2006

Self Cite

View full text Add to dashboard Cite

Aims/hypothesis Diabetes mellitus type 2 is associated with altered calcium metabolism. Moreover, in diseases with supranormal serum calcium levels, such as primary hyperparathyroidism, the prevalence of diabetes is increased. Relatively little is known about the relationship between serum calcium concentration and the underlying causes of diabetes-insulin resistance and defective insulin secretionin the normocalcaemic general population. Materials and methods We investigated associations between serum calcium concentration and insulin sensitivity and secretion in a population-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men, n=961). Insulin sensitivity index (M/I; glucose disposal rate [M] divided by mean insulin concentration [I]) was assessed using euglycaemic-hyperinsulinaemic clamp, and insulin secretion was estimated from the early insulin response (EIR) during an OGTT.Results In a multivariable linear regression model adjusting for BMI, physical activity, smoking, consumption of tea, alcohol, coffee and dietary calcium, serum phosphate and serum creatinine, 1 SD increase in serum calcium was associated with 0.17 mg kg −1 min −1 (mU/l) −1 × 100 (0.024 mg kg −1 min −1 [pmol/l] −1 ×100) decrease in M/I (p=0.01). The results remained robust in individuals with normal fasting glucose, normal glucose tolerance and serum calcium within the normal range (n=413, regression coefficient for 1 SD increase −0.45, p=0.001). Serum calcium was not associated with EIR. Dietary intake of calcium was not independently associated with insulin sensitivity or EIR. Conclusion/interpretation Our data support the notion that endogenous calcium may be involved early in the development of diabetes and that this effect is mediated mainly through effects on insulin sensitivity rather than defective insulin secretion. Dietary intake of calcium does not seem to influence insulin sensitivity.

show abstract

Cross‐sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice

Cousineau,

Loftus,

Churchill

et al. 2024

FEBS Open Bio

View full text Add to dashboard Cite

Genetically diverse outbred mice allow for the study of genetic variation in the context of high dietary and environmental control. Using a machine learning approach, we investigated clinical and morphometric factors that associate with serum cholesterol levels in 840 genetically unique Diversity Outbred mice of both sexes (n=417 male and 423 female), and on both a control chow (% kcals in diet: protein 22%, carbohydrate 62%, fat 16%, no cholesterol) and high fat high sucrose (% kcals in diet: protein 15%, carbohydrate 41%, fat 45%, 0.05% cholesterol). We find expected elevations of cholesterol in male mice, as well as in mice with elevated serum triglycerides and/or fed a high fat high sucrose diet. The third strongest predictor was serum calcium which correlated with serum cholesterol across both diets and sexes (r=0.39‐0.48) in both Diversity Outbred (p=3.0 x 10‐43) and BXD (p=0.005) mice. This is in‐line with several human cohort studies which show associations between calcium and cholesterol, and calcium as an independent predictor of cardiovascular events.

show abstract

Relation of serum calcium concentration to metabolic risk factors for cardiovascular disease.

Cited by 119 publications

References 33 publications

Serum calcium revisited: associations with 24-h ambulatory blood pressure and cardiovascular reactivity in Africans

Serum calcium revisited: associations with 24-h ambulatory blood pressure and cardiovascular reactivity in Africans

Serum calcium is independently associated with insulin sensitivity measured with euglycaemic–hyperinsulinaemic clamp in a community-based cohort

Cross‐sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice

Contact Info

Product

Resources

About