Relation of serum heart type fatty acid binding protein to left ventricular diastolic dysfunction in patients with type 2 diabetes and early diabetic kidney disease

Abdelaaty, Talaat; Morsy, Eman; Rizq, Mohammed; Shokry, Ahmed; Abdelhameid, Ahmed Kamal; Fathalla, Reem

doi:10.1016/j.jdiacomp.2021.108122

Cited by 3 publications

(4 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obtained result matches with those given in Otaki et al ( 61) and Abir et al (62). H-FABP is considered an important diagnostic biomarker for acute coronary syndrome and acute kidney damage (63) and its release into the blood circulation occurs after myocardial damage (49), and this obtained result was confirmed histopathologically where the heart tissue from DM rats showed various alterations that included cardiomyocyte death, vacuolation, hyalinization, shrinkage, a reduction in cardiomyocytes, and interstitial mononuclear inflammatory cell infiltration, which are characteristics of DM cardiac dysfunction, as demonstrated by a number of prior investigations (58,64). Deformation of cardiomyocyte nuclei and disarray or disorganized cardiac myofibrils were also observed.…”

Section: Discussionsupporting

confidence: 89%

“…Blinded observers measured the quantity of myocardial collagen using semiquantitative morphometric scoring of Masson's trichromestained slices. Each sample is represented by the average value of 20 randomly chosen visual fields (400× magnification) of a free LV wall (48,49). As regards the histomorphometric tissue scoring of the renal tissue, the tissue slices were cut at a thickness of 3-5µm and stained with hematoxylin and eosin, and periodic acid-Schiff (PAS).…”

Section: Morphometric Studymentioning

confidence: 99%

See 1 more Smart Citation

Melatonin ameliorates serobiochemical alterations and restores the cardio-nephro diabetic vascular and cellular alterations in streptozotocin-induced diabetic rats

et al. 2023

View full text Add to dashboard Cite

Melatonin possesses a wide range of pharmacological activities, including antidiabetic properties. Diabetes mellitus (DM) induces several physiopathological changes in body organs, which could be observed lately after systemic failure. In the current study, we aimed to investigate the serobiochemical changes and the histopathological picture in the diabetic heart and the kidney early before chronic complications and highlight the association between hyperglycemia, glomerular alterations, and cardiovascular changes. In addition, the role of melatonin in the treatment of cardio-nephro diabetic vascular and cellular adverse changes in streptozotocin-induced diabetic rats was also studied. A total of 40 mature Wistar albino rats were distributed into five groups; (1) control untreated rats, (2) diabetic mellitus untreated (DM) rats, in which DM was induced by the injection of streptozotocin (STZ), (3) control melatonin-treated (MLT), (4) melatonin-treated diabetic (DM + MLT) rats, in which melatonin was injected (10 mg/kg/day, i.p.) for 4 weeks, and (5) insulin-treated diabetic (DM + INS) rats. The serum biochemical analysis of diabetic STZ rats showed a significant (P < 0.05) increase in the concentrations of blood glucose, total oxidative capacity (TOC), CK-MB, endothelin-1, myoglobin, H-FABP, ALT, AST, urea, and creatinine as compared to control rats. In contrast, there was a significant (P < 0.05) decrease in serum concentration of insulin, total antioxidative capacity (TAC), total nitric oxide (TNO), and total protein level in DM rats vs. the control rats. Significant improvement in the serobiochemical parameters was noticed in both (DM + MLT) and (DM + INS) groups as compared with (DM) rats. The histological examination of the DM group revealed a disorder of myofibers, cardiomyocyte nuclei, and an increase in connective tissue deposits in between cardiac tissues. Severe congestion and dilation of blood capillaries between cardiac muscle fibers were also observed. The nephropathic changes in DM rats revealed various deteriorations in glomeruli and renal tubular cells of the same group. In addition, vascular alterations in the arcuate artery at the corticomedullary junction and interstitial congestion take place. Melatonin administration repaired all these histopathological alterations to near-control levels. The study concluded that melatonin could be an effective therapeutic molecule for restoring serobiochemical and tissue histopathological alterations during diabetes mellitus.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Morphometric Studymentioning

confidence: 99%

Melatonin ameliorates serobiochemical alterations and restores the cardio-nephro diabetic vascular and cellular alterations in streptozotocin-induced diabetic rats

et al. 2023

View full text Add to dashboard Cite

show abstract

“…E/A, as a common echocardiographic parameter representing diastolic dysfunction, respectively displayed an inverse correlation to the size and the intensity of the late diastolic vortex behavior. CKD-related increases to myocardial collagen causes diffuse myocardial interstitial fibrosis, resulting in decline of myocardial relaxation [ 3 ], which already appears in the early stages of type 2 diabetic CKD [ 25 ]. This deterioration of myocardial relaxation further leads to imperceptible diastolic dysfunction, with a decrease in passive filling and a compensatory increase in active atrial filling.…”

Section: Discussionmentioning

confidence: 99%

“…However, the vortex behavior and its potential clinical value in early CKD patients remain unclear. In the absence of cardiac morphological changes, it has been demonstrated that hemodynamic abnormalities due to the subclinical diastolic dysfunction can exist in the heart of early CKD [ 7 , 25 ]. Our work aimed to investigate the dynamic changes of LV vortex behavior using VFM in the type 2 diabetic patients with early CKD and to testify whether vortex is a potential way for observing the status of intracardiac blood flow and is useful for evaluating the diastolic dysfunction of those patients.…”

Section: Introductionmentioning

confidence: 99%

Vector flow mapping analysis of left ventricular vortex performance in type 2 diabetic patients with early chronic kidney disease

Chen,

Qiu,

Wang

et al. 2023

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Diabetes is the leading cause of chronic kidney disease (CKD) and contributes to an elevated incidence of diastolic dysfunction in the early stages of CKD. Intracardiac vortex is a novel hemodynamic index for perceiving cardiac status. Here, we visualized left ventricular (LV) vortex characteristics using vector flow mapping (VFM) in type 2 diabetic patients with early CKD. Methods This cross-sectional study included 67 controls and 89 type 2 diabetic patients with stages 2-3a CKD. All subjects underwent transthoracic echocardiographic examination. LV anterior vortex during early diastole (E-vortex), atrial contraction (A-vortex) and systole (S-vortex) were assessed using VFM in the apical long-axis view. Its relation to glycemia or LV filling echocardiographic parameters were further analyzed using correlation analysis. Results Type 2 diabetic patients with early CKD had a small area (439.94 ± 132.37 mm2 vs. 381.66 ± 136.85 mm2, P = 0.008) and weak circulation (0.0226 ± 0.0079 m2/s vs. 0.0195 ± 0.0070 m2/s, P = 0.013) of E-vortex, but a large area (281.52 ± 137.27 mm2 vs. 514.83 ± 160.33 mm2, P ˂ 0.001) and intense circulation (0.0149 ± 0.0069 m2/s vs. 0.0250 ± 0.0067 m2/s, P < 0.001) of A-vortex compared to controls. CKD patients with poorly controlled hyperglycemia had stronger A-vortex (area: 479.06 ± 146.78 mm2 vs. 559.96 ± 159.27 mm2, P = 0.015; circulation: 0.0221 ± 0.0058 m2/s vs. 0.0275 ± 0.0064 m2/s, P < 0.001) and S-vortex (area: 524.21 ± 165.52 mm2 vs. 607.87 ± 185.33 mm2, P = 0.029; circulation: 0.0174 ± 0.0072 m2/s vs. 0.0213 ± 0.0074 m2/s, P = 0.015), and a longer relative duration of S-vortex (0.7436 ± 0.0772 vs. 0.7845 ± 0.0752, P = 0.013) than those who had well-controlled hyperglycemia. Glycemia, and E/A (a LV filling parameter) were respectively found to had close correlation to the features of A-vortex and S-vortex (all P < 0.05). Conclusions Abnormal LV vortices were detected in type 2 diabetic patients with early CKD using VFM, especially in those who neglected hyperglycemic control. LV vortex might be a promising parameter to slow or halt the hyperglycemia-induced diastolic dysfunction in early CKD.

show abstract

Research progress of electrochemistry in detecting markers of cardiovascular disease

Hu,

Li,

Zhao

et al. 2023

Microchemical Journal

View full text Add to dashboard Cite

Relation of serum heart type fatty acid binding protein to left ventricular diastolic dysfunction in patients with type 2 diabetes and early diabetic kidney disease

Cited by 3 publications

References 42 publications

Melatonin ameliorates serobiochemical alterations and restores the cardio-nephro diabetic vascular and cellular alterations in streptozotocin-induced diabetic rats

Melatonin ameliorates serobiochemical alterations and restores the cardio-nephro diabetic vascular and cellular alterations in streptozotocin-induced diabetic rats

Vector flow mapping analysis of left ventricular vortex performance in type 2 diabetic patients with early chronic kidney disease

Research progress of electrochemistry in detecting markers of cardiovascular disease

Contact Info

Product

Resources

About