Relation of Serum Parathyroid Hormone Level to Severity of Heart Failure

Altay, Hakan; Zorlu, Ali; Binici, Süleyman; Bilgi, Muhammet; Yilmaz, Mehmet Birhan; Çölkesen, Yücel; Erol, Tansel; Müderrisoğlu, Haldun

doi:10.1016/j.amjcard.2011.08.039

Cited by 45 publications

(34 citation statements)

References 23 publications

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“…Altay, Zorlu, Bilgi, Erol, and Yilmaz (2012) studied 100 patients with HFpEF and found that PTH level >68.4 pg/ml had greater accuracy to predict HFpEF as compared with BNP level >168 pg/ml. In terms of advanced HF, they also demonstrated that PTH level >96.4 pg/ml was the great accurate cut-off (AUC 0.837) (Altay, Zorlu, Binici, et al 2012). With respect to the optimal cut-off value, PTH and NtproBNP levels were either higher or lower than previous reports because of different compositions of patients and the purpose of research.…”

Section: Discussionmentioning

confidence: 89%

Correlations between serum intact parathyroid hormone (PTH) and N-terminal-probrain natriuretic peptide levels in elderly patients with chronic heart failure (CHF)

Zhang

Zhou

et al. 2015

Archives of Gerontology and Geriatrics

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Section: Discussionmentioning

confidence: 89%

Correlations between serum intact parathyroid hormone (PTH) and N-terminal-probrain natriuretic peptide levels in elderly patients with chronic heart failure (CHF)

Zhang

Zhou

et al. 2015

Archives of Gerontology and Geriatrics

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“…We observed that RD was associated with increased PTH concentrations. Increased plasma concentrations of PTH in HF have been described previously and were in these studies related to HF severity, re‐admission rates, and mortality risk; but an association between RD and PTH concentrations in HF has not been reported previously …”

Section: Discussionmentioning

confidence: 99%

Influence of renal impairment on aldosterone status, calcium metabolism, and vasopressin activity in outpatients with systolic heart failure

et al. 2017

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AimsRenal dysfunction (RD) is associated with increased morbidity and mortality in heart failure (HF). At present, no specific treatment for patients with RD, to prevent progression of HF, has been developed. How different hormone axes—and thereby potential treatment options—are affected by RD in HF warrants further investigations.Methods and resultsPatients with left ventricular ejection fraction (LVEF) <0.45% were enrolled prospectively from an outpatient HF clinic. Glomerular filtration rate was estimated by the Chronic Kidney Disease Epidemiology Collaboration equation (eGFR), and patients were grouped by eGFR: eGFR group I, ≥90 mL/min/1.73 m2; eGFR group II, 60–89 mL/min/1.73 m2; and eGFR group III, ≤59 mL/min/1.73 m2. Multivariate linear regression models were developed to evaluate the associations between eGFR groups and hormones. A total of 149 patients participated in the study. Median age was 69 [interquartile range (IQR): 64–73] and 26% were female; LVEF was 33% (IQR: 27–39), 78% were in functional class II–III, median eGFR was 74 (54–89) mL/min/1.73 m2, and median N‐terminal pro‐brain natriuretic peptide was 1303 pg/mL (IQR: 441–2740). RD was associated with increased aldosterone, parathyroid hormone (PTH), and copeptin concentrations (P < 0.05 for all) after adjustment for traditional confounders and medical treatment.ConclusionsRD is associated with increased concentrations of aldosterone, PTH, and copeptin in systolic HF outpatients. Our results underscore the importance of treatment with mineralocorticoid receptor antagonist in systolic HF in particular in patients with RD and suggest that vasopressin and parathyroid receptor antagonism are potential treatment options in HF patients with known RD.

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“…A recent study demonstrated that high serum PTH levels were strongly associated with advanced HF 11 . This association has been explained by the fact that secondary hyperparathyroidism may contribute to the systemic illness that .…”

Section: Discussionmentioning

confidence: 99%