Relation of Spontaneous Reperfusion in ST-Elevation Myocardial Infarction to More Distal Coronary Culprit Narrowings

Leibowitz, David; Gerganski, Penko; Nowatzky, Johannes; Weiss, A. Teddy; Rott, David

doi:10.1016/j.amjcard.2007.08.036

Cited by 9 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general the clinical characteristics of patients with STEMI and SR are similar to patients without SR with no significant differences in age, risk factors, location of infarctrelated artery, etc. We have previously demonstrated that the culprit lesion in SR patients is more distal in the culprit artery suggesting an important role for coronary anatomy in determining whether SR takes place (22). Importantly for the aims of our study, there was no difference in the incidence of diabetes in patients with and without SR in these studies, supporting our contention that the prognostic impact of hyperglycemia is not related to impaired early macrovascular perfusion.…”

Section: Discussionsupporting

confidence: 62%

Acute hyperglycemia and spontaneous reperfusion in acute myocardial infarction

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 62%

Acute hyperglycemia and spontaneous reperfusion in acute myocardial infarction

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…Of note, angiographic information available in all patients in this study showed that patients with NSTEMI had more extensive coronary artery disease, a smaller size of vessels with culprit lesions and a more distal location of culprit lesions. Since a recent study has suggested that more distally located culprit lesions are more prone to spontaneous reperfusion following thrombotic occlusion [24], this latter fact might also have implications for the pathophysiology of NSTEMI. In contrast to patients with STEMI who showed higher rates of early mortality, patients with NSTEMI showed higher rates of mortality between 1 month and 1 year following PCI.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Presentation and Outcomes of Patients with Acute Coronary Syndromes

et al. 2009

View full text Add to dashboard Cite

Objectives: We undertook this study to assess the relationship between presentation pattern and mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention. Methods: This registry included 10,455 patients with ACS, of whom 2,853 patients had ST-segment elevation myocardial infarction(STEMI), 3,060 patients had non-ST-segment elevation myocardial infarction (NSTEMI) and 4,542 patients had unstable angina. The primary outcome was 1-year mortality. Results: At 1 year there were 976 deaths, 390 (13.7%) among STEMI patients, 366 (12.0%) among NSTEMI patients and 220 (4.8%) among patients with unstable angina (OR = 1.17, 95% CI 1.01–1.35 for STEMI vs. NSTEMI; OR = 3.00, 95% CI 2.56–3.51 for STEMI vs. unstable angina, and OR = 2.58, 95% CI 2.20–3.04 for NSTEMI vs. unstable angina). In the Cox proportional hazards model ACS form was an independent correlate of 1-year mortality (HR = 0.90, 95% CI 0.73–1.13 for STEMI vs. NSTEMI; HR = 1.56, 95% CI 1.13–2.14 for STEMI vs. unstable angina; HR = 1.72, 95% CI 1.30–2.29 for NSTEMI vs. unstable angina). Conclusions: The presentation pattern affects 1-year mortality in patients with ACS, with unadjusted mortality being highest in patients with STEMI and lowest in patients with unstable angina.

show abstract

“…Frequency of TIMI III flow in pre-pPCI ranges between 10-30% [ 9 , 10 ]. This study was conducted to find out the frequency of TIMI III flow in acute STEMI.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Thrombolysis in Myocardial Infarction III Flow in Patients With Primary Percutaneous Coronary Intervention: Not All Culprit Vessels Are Completely Occluded in ST Elevation Myocardial Infarction

Hussain¹,

Kumar²,

Ammar³

et al. 2020

Cureus

View full text Add to dashboard Cite

BackgroundST elevation myocardial infarction (STEMI) is classically characterized by total occlusion of the culprit coronary artery. However during primary percutaneous coronary intervention (PCI) thrombolysis in myocardial infarction (TIMI) 0 flow is not observed in all patients' culprit arteries in angiographic views. This study was conducted to find out the frequency of TIMI flow in acute STEMI patients in view of the above concept. The aim of this study was to evaluate the frequency of pre-procedural TIMI III flow in those patients who underwent primary PCI for acute STEMI in a public sector hospital in Karachi, Pakistan. MethodologyThis study is an audit of already saved data in the catheterization laboratory of the National Institute of Cardiovascular Diseases (NICVD), Karachi, that was collected prospectively from January 2016 to December 2018. These data were collected after taking consent from those patients who presented to hospital within 12 hours of symptoms and underwent primary PCI. Data were entered and analyzed on Statistical Package for the Social Sciences (SPSS) version 19 (IBM Corp., Armonk, NY, USA). ResultsA total of 8018 patients were included in this study who presented with STEMI and underwent primary PCI. Out of them 80.9% were males. Hypertension was the leading risk factor in 54.1% (4340) of patients. TIMI III flow was present in 11.4% of patients before primary PCI, while TIMI 0, I and II flow were present in 57.1%, 15.1%, and 16.3% of patients respectively (p<0.001). Fourteen percent of patients with TIMI III flow were of age group 51 to 60 years. Among those who had TIMI III flow, 11.2% were those with door to balloon time of <90 minutes. In 11% of cases, left anterior descending (LAD) artery had TIMI III flow as compared to other vessels (p<0.001). The length of the lesion was significantly smaller in patients who had TIMI III flow compared to those who had TIMI 0-II flow. ConclusionsThis study revealed that not all patients with acute STEMI had totally occluded culprit coronary artery but some of them had angiographic TIMI I-III flow in the infarct-related artery. Further studies are needed to find the reason for re-establishment of flow in the culprit vessel in STEMI patients before PCI.

show abstract

Relation of Spontaneous Reperfusion in ST-Elevation Myocardial Infarction to More Distal Coronary Culprit Narrowings

Cited by 9 publications

References 11 publications

Acute hyperglycemia and spontaneous reperfusion in acute myocardial infarction

Acute hyperglycemia and spontaneous reperfusion in acute myocardial infarction

Patterns of Presentation and Outcomes of Patients with Acute Coronary Syndromes

Frequency of Thrombolysis in Myocardial Infarction III Flow in Patients With Primary Percutaneous Coronary Intervention: Not All Culprit Vessels Are Completely Occluded in ST Elevation Myocardial Infarction

Contact Info

Product

Resources

About