Relation of thromboelastography parameters to conventional coagulation tests used to evaluate the hypercoagulable state of aged fracture patients

Liu, Chen; Zhao, Ge; Xu, Qinzhu; Zhao, Lei; Song, Ying; Wang, Hui

doi:10.1097/md.0000000000003934

Cited by 35 publications

(45 citation statements)

References 24 publications

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“…The relationship between TEG parameters and coagulation tests is weak, and the diagnostic sensitivity of TEG and routing coagulation tests in patients with bleeding is low . TEG does not replace conventional coagulation tests, and the optimal method, which could reflect the risk of bleeding, remains uncertain .…”

Section: Discussionmentioning

confidence: 99%

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An in vitro study of coagulation properties in refrigerated whole blood and reconstituted whole blood

Wang

Zhao

et al. 2019

Vox Sanguinis

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Objective Fresh whole blood (WB) has been used in military applications and cardiac surgery. We undertook a study of the coagulation properties of refrigerated WB stored for 21 days and compared them with the properties of reconstituted WB. Study design and methods Ten WB units were obtained from healthy volunteer donors and stored at 4 ± 2°C. Samples were obtained on Days 1, 2, 4, 6, 8, 10, 14 and 21 from the WB units. Ten units of reconstituted WB were prepared with a ratio of red cells, platelets and plasma of 1:1:1. Tests included complete blood count, electrolyte, routine coagulation, blood coagulation factor and thromboelastography. Results There was a progressive decline in Hb, WBC, PLT, sodium and coagulation factors but a progressive increase in APTT, PT and potassium in WB. The concentrations of factor (F)V and FVIII as well as FII and FX of WB were higher before Days 4, 2, 8 and 14, respectively, compared with the concentrations of reconstituted WB. The concentrations of FVII, FIX, FXI and FXII in WB were found to be equal to or higher than those in reconstituted WB throughout the course of 21 days. TEG variables in all WB units were normal throughout the course of 10 days. The mean PT and APTT of WB were lower than those of reconstituted WB before Days 14 and 10, respectively. Conclusion This study suggests that the coagulation properties of refrigerated WB were equal to or superior to those of reconstituted WB for a minimum of 10 days.

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Section: Discussionmentioning

confidence: 99%

“…TEG does not replace conventional coagulation tests, and the optimal method, which could reflect the risk of bleeding, remains uncertain . A normal TEG has been shown to have a high negative predictive value for inadequate haemostasis due to coagulopathy .…”

Section: Discussionmentioning

confidence: 99%

An in vitro study of coagulation properties in refrigerated whole blood and reconstituted whole blood

Wang

Zhao

et al. 2019

Vox Sanguinis

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“…A decreased MA is indicative of low clot strength, which could be due to decreased platelet contribution or decreased fibrinogen, whereas an increased MA is indicative of high clot strength, which could be due to increased platelet contribution. 8,10,12,13,18,21,25,27 Citrated Functional Fibrinogen (CFF)…”

Section: Crt Mamentioning

confidence: 99%

A comparison between the TEG 6s and TEG 5000 analyzers to assess coagulation in trauma patients

Neal

Moore

Walsh

et al. 2019

J Trauma Acute Care Surg

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We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. Although this letter refers to your product as a device, please be aware that some cleared products may instead be combination products. The 510(k) Premarket Notification Database located at https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm identifies combination product submissions. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you, however, that device labeling must be truthful and not misleading.

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“…In addition, TEG has been demonstrated to be able to detect hypercoagulable states and predict thromboembolic complications after surgery [6,16,17]. From TEG parameters short R (reaction time) and K (kinetics time), large a (angle), elevated MA (maximum amplitude) and low LY60 (percent lysis at 60 min, reduced lysis) are considered as signs of hypercoagulation [6,18,19].…”

Section: Introductionmentioning

confidence: 99%

Hyperthermic intraperitoneal chemotherapy enhances blood coagulation perioperatively evaluated by thromboelastography: a pilot study

Tuovila

Erkinaro

Takala

et al. 2020

International Journal of Hyperthermia

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Background and Objectives: Postoperative thromboembolism is a significant cause of prolonged recovery in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Thromboelastography (TEG) can detect hypercoagulable states and predict thromboembolic complications after surgery. This study assessed the impact of CRS and HIPEC on TEG values. Methods: TEG parameters reaction time (R), kinetics time (K), angle (a), maximum amplitude (MA), and lysis percent at 60 min (LY60) were determined preoperatively, and at the end of CRS, during HIPEC, and at the end of the operation using blood samples from 15 HIPEC patients. Platelets, P-TT, and aPTT were also determined before and after CRS. Results: A total of 75 samples were analyzed. During CRS, there was a significant reduction in the mean MA (3.06 mm, p ¼ 0.001). The mean P-TT declined by 32% (p < 0.001) and mean platelets by 55 Â 10 9 /L (p < 0.001). During HIPEC, the mean R and K shortened by 1.04 min (p ¼ 0.015) and 0.18 min (p ¼ 0.018), respectively, whereas a increased by 2.48 (p ¼ 0.005). Conclusions: During CRS, both TEG and conventional laboratory tests indicated hypocoagulation. During HIPEC, however, the initiation of coagulation and the kinetics of thrombin formation were accelerated. ARTICLE HISTORY

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Relation of thromboelastography parameters to conventional coagulation tests used to evaluate the hypercoagulable state of aged fracture patients

Cited by 35 publications

References 24 publications

An in vitro study of coagulation properties in refrigerated whole blood and reconstituted whole blood

An in vitro study of coagulation properties in refrigerated whole blood and reconstituted whole blood

A comparison between the TEG 6s and TEG 5000 analyzers to assess coagulation in trauma patients

Hyperthermic intraperitoneal chemotherapy enhances blood coagulation perioperatively evaluated by thromboelastography: a pilot study

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