Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers

González‐Quintela, Arturo; Domínguez-Santalla, Maria-Jesus; Loidi, Lourdes; Quinteiro, Celsa; Pérez, Luis Francisco

doi:10.1016/j.alcohol.2004.06.011

Cited by 11 publications

(10 citation statements)

References 20 publications

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“…Oxidative stress and certain interleukins have been demonstrated to enhance HIV replication through these pathways A specific cell activity unrelated to HIV infection is cell activation via alcohol exposure. As observed in alcoholics, elevated levels of tumor necrosis contribute to the activation of NF-κB (Gonzalez-Quintela et al, 2004;NIAAA, 2004).…”

Section: Viral Replicationmentioning

confidence: 97%

Expanding Research on the Role of Alcohol Consumption and Related Risks in the Prevention and Treatment of HIV_AIDS

Bryant

2006

Substance Use & Misuse

105

110

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This article is a review of some of the major epidemiological, behavioral, biological, and integrative prevention research issues and priorities in the area of HIV/AIDS and alcohol consumption. Drinking alcohol increases both the risk for infection with HIV and related illnesses and the morbidity and mortality of patients who progress to AIDS. New and improved measurement procedures have helped in assessment of the complex patterns of alcohol use, identification of intervening explanatory mechanisms for risk behaviors and contexts, and determination of intervention outcomes. Both the direct and indirect effects of alcohol misuse appear to be major contributors to both the risk for infection with HIV and the transmission of HIV/AIDS at the individual and population levels. There is increasing evidence that perhaps no level of alcohol consumption is "safe" for those who are HIV infected and receiving antiretroviral treatment. Interdisciplinary basic behavioral and biomedical research is needed to develop comprehensive culturally appropriate strategies for programs that can be effectively delivered in community contexts in the United States and abroad and that focus on the integration of our understanding of individual behaviors, high-risk group membership, biological mechanisms, and the social and physical environments that place individuals at risk for HIV infection. High-priority topics include improving adherence to antiretroviral medications, prevention of infection in young minority women in the United States, and treatment of HIV+ pregnant women who are alcohol abusers to prevent adverse fetal outcomes, which is an international focus in under-resourced settings in Africa.

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Section: Viral Replicationmentioning

confidence: 97%

Expanding Research on the Role of Alcohol Consumption and Related Risks in the Prevention and Treatment of HIV_AIDS

Bryant

2006

Substance Use & Misuse

105

110

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“…For example, human studies found a link between NFKB1 [43] and TNF [44,45] polymorphisms and alcohol abuse. Genetic linkage of the IL-1 and IL-1 receptor antagonist genes to alcoholism has also been reported [46,47].…”

Section: Genomic and Behavioral Evidence For A Role Of Alcohol In Innmentioning

confidence: 99%

Neuroimmune signaling: a key component of alcohol abuse

Mayfield

Ferguson

Harris

2013

Current Opinion in Neurobiology

177

134

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Molecular and behavioral studies corroborate a pivotal role for the innate immune system in mediating the acute and chronic effects of alcohol and support a neuroimmune hypothesis of alcohol addiction. Changes in expression of neuroimmune genes and microglial transcripts occur in post-mortem brain from alcoholics and animals exposed to alcohol, and null mutant animals lacking certain innate immune genes show decreased alcohol-mediated responses. Many of the differentially expressed genes are part of the toll like receptor signaling pathway and culminate in increased expression of pro-inflammatory immune genes. Compounds known to inhibit inflammation, microglial activation, and neuroimmune gene expression have shown promising results in reducing alcohol-mediated behaviors in animal models, indicating that neuroimmune signaling pathways offer unexplored targets in the treatment of alcohol abuse.

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“…5 The TNF j308 promoter polymorphism associates with elevated TNF levels among patients with the G allele. 6,7 In addition, TNF j308 A/G polymorphism has been associated with severe sepsis, but not with mortality, in AP. 8 There are, however, also studies that did not find any associations between the TNF j308 A/G polymorphism and disease severity in AP.…”

mentioning

confidence: 99%

Polymorphisms of the TNF, CD14, and HSPA1B Genes in Patients With Acute Alcohol-Induced Pancreatitis

Tukiainen

Kylänpää²,

Puolakkainen³

et al. 2008

Pancreas

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Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers

Cited by 11 publications

References 20 publications

Expanding Research on the Role of Alcohol Consumption and Related Risks in the Prevention and Treatment of HIV_AIDS

Expanding Research on the Role of Alcohol Consumption and Related Risks in the Prevention and Treatment of HIV_AIDS

Neuroimmune signaling: a key component of alcohol abuse

Polymorphisms of the TNF, CD14, and HSPA1B Genes in Patients With Acute Alcohol-Induced Pancreatitis

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