Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population

Yıldız, Serkan; Tümer, Mehmet Kemal; Yığıt, Serbülent; Rüstemoğlu, Aydın; Balel, Yunus

doi:10.1016/j.bjoms.2020.08.101

Cited by 17 publications

(25 citation statements)

References 22 publications

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“…In contrast, our results suggest that vitamin D deficiency is a negative predictor of TMDs in COVID-19 infection. That comes in contradiction with the results of several studies that found that vitamin D deficiency is positively related to TMDs [29,30].…”

Section: Discussioncontrasting

confidence: 94%

The Prevalence and Predicting Factors of Temporomandibular Disorders in COVID-19 Infection: A Cross-Sectional Study

Haddad¹,

Sayegh²,

Zoghbi³

et al. 2022

Cureus

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IntroductionDuring the pandemic of coronavirus disease 2019 , an increase in temporomandibular disorders (TMDs) was noticed in infected patients. In the present study, we aimed to assess the prevalence of TMDs during COVID-19 infection and to evaluate associated factors. MethodsAn observational cross-sectional online survey was conducted in April and May 2021 in order to estimate the prevalence of TMDs in participants who were previously infected with COVID-19. A multivariable logistic regression model was carried out to explore predicting factors of TMDs during COVID-19 infection. ResultsIn total, the prevalence of TMDs during the COVID-19 infection period among participants was 41.9%. High fever episodes (adjusted odds ratio {aOR}: 3.25), gastro-esophageal reflux (aOR: 2.56), and toothache (aOR: 3.83) during COVID-19 illness were found to be positive predictors of TMDs, while vitamin D deficiency was found to be a negative predictor (aOR: 0.28). ConclusionOur study has highlighted a relatively high prevalence of TMDs in COVID-19-infected patients that may conclude TMDs as a possible COVID-19 symptom. Further studies are warranted to confirm the association between TMDs and COVID-19 infection and thereupon include TMDs among the known symptoms of COVID-19.

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Section: Discussioncontrasting

confidence: 94%

The Prevalence and Predicting Factors of Temporomandibular Disorders in COVID-19 Infection: A Cross-Sectional Study

Haddad¹,

Sayegh²,

Zoghbi³

et al. 2022

Cureus

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“…The case–control study included 104 Turkish patients diagnosed with DDR and 102 healthy Turkish individuals, investigating a Bsml variant of VDR. The authors concluded that the Bsml variant of the VDR gene , as well as the low levels of vitamin D, plays a role in the etiology and pathogenesis of disk displacements with reduction [ 37 ].…”

Section: Current Status Of Knowledgementioning

confidence: 99%

Vitamin D and Temporomandibular Disorders: What Do We Know So Far?

et al. 2021

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Background and aims. Vitamin D is synthesized in the skin with the aid of ultraviolet-B radiation, playing a variety of roles in the body. Temporomandibular disorders (TMDs) are a group of pathological conditions involving the temporomandibular joints as well as the masticatory muscles and othersurrounding tissues. In the present narrative review, we investigated the potential role of vitamin D in the etiology of temporomandibular disorders in order todetermine whether the current knowledge supports 25-hidroxyvitamin D (25-OHD) supplementation in temporomandibular disorders associated with insufficient or deficient levels of vitamin D. Methods. A literature research was performed in PubMed, Scopus, Science Direct, and Google Scholar databases, and a total of 10 articles were included for analysis. Results.Among the observational studies published to date, investigating the role for vitamin D in the etiology of TMDs, six of them suggest that there is a connection between the two aspects. In this context, patients suffering from TMD, with deficient levels of vitamin D (<30 ng/mL), are most likely to benefit from supplementation, whereas individuals with vitamin D level >50ng/mL probably have little benefit from supplementation.Conclusion.Vitamin D might be a safe, simple, and potentially beneficial way to prevent TMDs or to reduce pain; however, more randomized and placebo-controlled trials are required before any firm conclusions can be drawn.

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“…The publication year of the studies that were included in this review ranged between 2017 [ 35 , 36 ] and 2022 [ 37 ]. The nationalities of the studies included in this review were as follows: seven studies (69%) were conducted in Asia (two in Iran [ 38 , 39 ], three in India [ 36 , 37 , 40 ], one in Iraq [ 35 ], and one in Korea [ 41 ]); one study (8%) was conducted in Europe (in Norway [ 42 ]); and the remaining three studies (23%) were Turkish [ 43 , 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…Seven were cross-sectional studies [ 35 , 36 , 37 , 38 , 39 , 42 , 45 ], two had a prospective observational design [ 41 , 43 ], one was a prospective case-control study [ 44 ], and one study was a randomized controlled trial [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

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Temporomandibular Disorders and Vitamin D Deficiency: What Is the Linkage between These Conditions? A Systematic Review

Ferrillo

Lippi

Giudice

et al. 2022

JCM

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Although a growing body of literature has been emphasizing the role of vitamin D in oral health, there is still a gap of knowledge regarding the correlation between temporomandibular disorders (TMDs) and vitamin D. Therefore, the aim of this systematic review was to assess the linkage between hypovitaminosis D and TMDs to map the current literature in this field. On 10 September 2022, PubMed, Scopus, and Web of Science databases were systematically searched from the date of their inception to identify the studies that had assessed patients with TMDs. The primary outcome assessed in this review was the relationship between hypovitaminosis D and TMDs. Out of the 329 studies identified, 13 studies met the eligibility criteria and were included in the present work. Seven studies assessed the relationship between vitamin D and TMDs, reporting that vitamin D serum levels are lower in patients with TMDs. Our results suggested that vitamin D receptor (VDR) polymorphisms might have a role in TMDs’ development. However, the quality assessed underlined that only one study did not present a serious risk of bias. Further good-quality studies are needed to clarify the linkage between vitamin D deficiency and TMDs, but the evidence currently available has suggested potential correlations.

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Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population

Cited by 17 publications

References 22 publications

The Prevalence and Predicting Factors of Temporomandibular Disorders in COVID-19 Infection: A Cross-Sectional Study

The Prevalence and Predicting Factors of Temporomandibular Disorders in COVID-19 Infection: A Cross-Sectional Study

Vitamin D and Temporomandibular Disorders: What Do We Know So Far?

Temporomandibular Disorders and Vitamin D Deficiency: What Is the Linkage between These Conditions? A Systematic Review

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