In the 30+ years since House, Landis, and Umberson (1988) published one of the first papers establishing links between close relationships and physical health, this subfield has blossomed substantially. We have an ever-growing body of evidence indicating that higher-quality relationships are associated with better physical health outcomes (Slatcher & Selcuk, 2017; Smith & Weihs, 2019). Meta-analyses suggest that the quantity and quality of close relationships have a comparable (or even larger) effect size on mortality rates than classic health risk factors such as cigarette use, exercise, and body mass index (Holt-Lunstad, Smith, & Layton, 2010; Robles, Slatcher, Trombello, & McGinn, 2014). The strength of these associations, along with welldocumented links between relationship quality, mental health, and well-being, has led researchers to call for social connections to be treated as a public health issue (Holt-Lunstad, Robles, & Sbarra, 2017) and has increased enthusiasm for relationship-focused health interventions. Despite the exciting work that has been conducted in this area over the past several decades, we know surprisingly little about why and how relationships promote better health, making it difficult to design efficient interventions and test their effectiveness. A recent review of the mechanistic literature on relationships and health found that although many mechanisms underlying relationship-health links have been proposed, psychological and behavioral mechanisms have been woefully understudied and the types of evidence that would establish these variables as true mechanisms are lacking (Farrell & Stanton, 2019). Our recent special issue of Personal Relationships (Vol. 27, Issue 3) aimed to begin filling this gap and galvanize research on biological, psychological, and behavioral mechanisms linking close relationships and health.