Land abandonment and rural depopulation are escalating worldwide, presenting sustainability dilemmas for both rural and urban regions. However, there remains a dearth of research on the sociocultural dimensions of abandonment from a local standpoint. This investigation focuses on a case study conducted in southeastern Spain, wherein a social survey was used to evaluate the perspectives of local communities concerning human–nature interconnectedness, land abandonment, and their impacts on quality of life. A survey campaign was administered in the case study region during the spring of 2021, and 122 surveys were collected. The findings identify, in the context of the progressive abandonment of rural lands in Spain, key factors that explain the desire of local people to inhabit and not abandon rural regions in southeastern Spain. Our results also show a strong connection between people and nature in rural Spain, which is explained by the capacity of locals to form relational values in rural environments and the existence of philosophical worldviews and emotional attachments to rural lifestyles. However, barriers to not abandoning rural environments were also identified, including a lack of professional and economic opportunities. Our results suggest that the mitigation of depopulation in rural areas in Spain requires actions to foster land stewardship and address socioeconomic imbalances.