Relations between Circulating Levels of Testosterone, 17&amp;beta;-Estradiol, Androstenedione, Dehydroepiandrosterone Sulfate, and Androgenic Receptor Content of Cytosol in Benign Prostatic Hyperplasia

Corrales, J. J.; Garcia, J Rodriguez; Høisæter, Per Å.; Martín, T.; Diez, Laurent; Gómez, J Montero

doi:10.1159/000280873

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…Our data on R -1881 binding in cytosol ofhum an BPH are comparable with those previously reported by Ekman et al [12], Hernandez et al [13] and Menon etal. [3], 47% of total cellular R -1881 binding was localized to the cyto plasmic compartment.…”

Section: Discussionsupporting

confidence: 93%

Determination of Androgen Receptors in Human Benign Prostatic Hypertrophy with Two Synthetic Radiolabeled Ligands

Schwemmer¹,

Böttger²,

Schiessl

et al. 1986

Urol Int

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Nuclear and cytosolic androgen receptor concentrations in tissues of human benign prostatic hypertrophy (BPH) were determined by use of methyltrienolone (R-1881) and 7Α,17Α-dimethyl-19-nortestosterone (DMNT) as radiolabeled ligands. Cytosolic R-1881-binding sites were 46.1 ± 43 fmol/mg protein and nuclear R-1881-binding sites were 51.8 ± 42 fmol/mg protein. DMNT-binding sites in cytosol were 44.3 ± 38 fmol/mg protein and in nuclear extract 73.4 ± 64 fmol/mg protein. No significant correlation was found between the number of R-1881 – and DMNT-binding sites in either cytosol or nuclear extracts. Cytosolic or nuclear androgen receptor content was not significantly correlated with the percentage of epithelial or stromal cells as determined from the corresponding histological sections. In BPH tissue with marked cystic degeneration, very low androgen receptor levels were found.

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Section: Discussionsupporting

confidence: 93%

Determination of Androgen Receptors in Human Benign Prostatic Hypertrophy with Two Synthetic Radiolabeled Ligands

Schwemmer¹,

Böttger²,

Schiessl

et al. 1986

Urol Int

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Renal malignancies in the elderly

Gomez¹,

Avisrror²,

Hernandez³

1987

Renal Function and Disease in the Elderly

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Blood and tissue steroid levels and their interrelationship in men with pathological conditions of the reproductive organs

et al. 1986

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We have investigated the interrelationship of the levels of 10 steroids in peripheral venous, spermatic arterial and spermatic venous blood, and in tissue specimens from the epididymis, vas deferens and testis from 8 patients who underwent orchidectomy for pathological conditions of the reproductive organs. The steroids analyzed by radioimmunoassay were: pregnenolone (5-P), dehydroepiandrosterone (DHEA), 17-hydroxyprogesterone (17-OH-P), androstenedione (A), testosterone (T), dihydrotestosterone (DHT) and the sulpho-conjugated forms (-S) of 5-P, DHEA, T and DHT. The quantitatively major steroids in peripheral venous blood were, in order of magnitude, DHEA-S, 5-P-S, DHT-S, T-S and T. No difference was observed between the levels of any of the steroids measured in peripheral venous and spermatic arterial blood. With the exception of DHEA-S and DHT-S, the levels of all steroids in spermatic venous blood were substantially higher than in peripheral venous blood (P less than 0.001). No correlation was found between steroid levels in spermatic venous and peripheral venous blood. Steroid concentrations in tissue from the epididymis, vas deferens and testis were markedly higher than in peripheral venous blood (P less than 0.01 to P less than 0.001), except for the levels of DHEA-S which were about equal in the various blood and tissue specimens. Tissue to blood ratios varied from approximately 2.0 to 500 according to the steroid in question. The peripheral blood levels of 5-P-S, DHEA-S and DHT-S were substantially higher than respective unconjugated steroid levels (P less than 0.001); the ratios (sulpho-conjugated to unconjugated) were approximately 17, 215 and 30, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

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Relations between Circulating Levels of Testosterone, 17β-Estradiol, Androstenedione, Dehydroepiandrosterone Sulfate, and Androgenic Receptor Content of Cytosol in Benign Prostatic Hyperplasia

Cited by 5 publications

References 21 publications

Determination of Androgen Receptors in Human Benign Prostatic Hypertrophy with Two Synthetic Radiolabeled Ligands

Determination of Androgen Receptors in Human Benign Prostatic Hypertrophy with Two Synthetic Radiolabeled Ligands

Renal malignancies in the elderly

Blood and tissue steroid levels and their interrelationship in men with pathological conditions of the reproductive organs

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