Relations between natural killer cytotoxicity and interferon systems in immobilization stress

Сухих, Г. Т.; Nosik, N. N.; Паршина, О В; Van'ko, L. V.; Меерсон, Ф. З.; Ершов, Ф. И.

doi:10.1007/bf00800033

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2011

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“…Recent studies of the cytotoxic activity of splenic NK cells confi rm the existence of mouse strains with genetically determined high or low activity of NK cells [6]. C57Bl/6 mice belong to the former group.…”

Section: Resultsmentioning

confidence: 98%

Morphofunctional Characteristic of the Immune System in BALB/c and C57Bl/6 Mice

et al. 2011

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Inbred animals serve as an adequate model to study the role of genetic factors in adaptive, disadaptive, and pathological processes. Morphofunctional study of the immune system was performed on intact BALB/c and C57Bl/6 mice. The structural and functional parameters of the immune system in BALB/c and C57Bl/6 mice differ under physiological conditions. In BALB/c mice, volume density of T zone in the spleen and production of IL-2, IL-3, IL-4, IL-10, and TNF-α were much higher than in C57Bl/6 mice. However, IL-12 production in BALB/c mice was lower than in C57Bl/6 mice. C57Bl/6 mice were characterized by higher cytostatic activity of splenic NK cells. The observed interstrain differences are genetically determined and contribute to the type of adaptive processes and different sensitivity of these mice to pathogenic agents.

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Section: Resultsmentioning

confidence: 98%