Relations of cardiovascular risk factors to aortic pulse wave velocity in asymptomatic middle-aged women

Taquet, AN; Bonithon‐Kopp, Claire; Simon, Alain; Levenson, Jaime; Scarabin, Y.; Malméjac, A; Ducimetière, Pierre; Guize, L

doi:10.1007/bf00146267

Cited by 99 publications

(82 citation statements)

References 35 publications

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“…Our findings that traditional risk factors were associated with all 3 measures of subclinical cardiovascular disease are consistent with our previous findings in women with SLE and the findings of other studies in nonlupus populations (36)(37)(38)(39)(40)(41). These factors include older age, high blood pressure, high cholesterol, smoking, and elevated glucose and insulin levels.…”

Section: Discussionsupporting

confidence: 92%

Comparison of risk factors for vascular disease in the carotid artery and aorta in women with systemic lupus erythematosus

Selzer¹,

Sutton-Tyrrell²,

Fitzgerald³

et al. 2004

Arthritis & Rheumatism

193

134

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Objective. To examine and compare risk factors for various stages of subclinical vascular disease in different vascular beds (carotid and aorta) in women with systemic lupus erythematosus (SLE) who have not yet developed clinical cardiovascular disease.Methods. This cross-sectional study was conducted in 214 women without clinical cardiovascular disease who were enrolled in the Pittsburgh Lupus Registry. B-mode ultrasound was used to measure carotid plaque and intima-media wall thickness (IMT). Doppler probes were used to collect pulse-wave velocity waveforms from the right carotid and femoral arteries as a measure of aortic stiffness. All risk factor data were collected on the day of the ultrasound examinations.Results. The mean ؎ SD age of the women was 45.2 ؎ 10.5 years and the median SLE disease duration was ϳ9 years. Sixty-eight (32%) of the women had at least 1 focal plaque. The mean ؎ SD IMT was 0.71 ؎ 0.1 mm, and the mean ؎ SD pulse-wave velocity was 5.96 ؎ 1.6 meters/second. Using logistic regression, we found that determinants of plaque included older age, higher systolic blood pressure, lower levels of high-density lipoprotein 3, and antidepressant use. Determinants of plaque severity were older age, higher systolic blood pressure, lower levels of albumin, and smoking. Independent determinants of the highest quartile of IMT were older age, higher pulse pressure, lower levels of albumin, elevated C-reactive protein levels, high cholesterol, and higher levels of glucose. Higher aortic stiffness was associated with older age, higher systolic blood pressure, higher C3 levels, lower white blood cell count, higher insulin levels, and renal disease.Conclusion. In women with SLE, the risk factors associated with carotid plaque and IMT are those typically associated with cardiovascular disease in the general population, whereas the risk factors associated with vascular stiffness include SLE-specific variables related to immune dysregulation and complement metabolism. The high prevalence of cardiovascular disease among lupus patients may result from both early adverse effects on vascular stiffening as well as later promotion of wall thickening and plaque through inflammatory-mediated processes. These observations provide clues for future mechanistic studies.Systemic lupus erythematosus (SLE) affects primarily women and causes chronic vascular inflammation. Women with SLE, particularly those under age 45 years, experience higher than expected rates of clinical cardiovascular disease, i.e., hypertension (1-3), myocardial infarction (1,4), and stroke (4). In addition to traditional cardiovascular risk factors, other factors specifically associated with SLE appear to be equally, if not more, important (5,6). It is likely that these factors are related to the underlying immune-mediated, inflammatory processes inherent in SLE.Although the pathogenesis of vascular disease in SLE is unknown, it is thought to be multifactorial and of atherosclerotic origin. Atherosclerosis involves both atherosis (fatty degeneration) an...

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Section: Discussionsupporting

confidence: 92%

Comparison of risk factors for vascular disease in the carotid artery and aorta in women with systemic lupus erythematosus

Selzer¹,

Sutton-Tyrrell²,

Fitzgerald³

et al. 2004

Arthritis & Rheumatism

193

134

View full text Add to dashboard Cite

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“…Some studies have also shown that arterial stiffness measured by carotid-femoral PWV reflects the sclerotic rather than atherotic component of atherosclerosis. 21,36) These findings suggest that the influence of lipid parameters on PWV is weak.…”

Section: Discussionmentioning

confidence: 95%

Relationship Between Markers of Inflammation and Brachial-Ankle Pulse Wave Velocity in Japanese Men

et al. 2006

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SUMMARYThe objective of the present study was to examine the relationship between markers of inflammation, such as high-sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR), and brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, in Japanese men.We studied 269 male subjects (mean age, 53 years) who entered our health check-up program. Subjects who were receiving any medication were excluded from the study. baPWV was measured using a volume-plethysmographic apparatus (Form /ABI; Colin, Co. Ltd., Komaki, Aichi, Japan). In addition to routine laboratory tests including ESR, serum levels of hsCRP were determined by a highly sensitive ELISA technique.baPWV was significantly correlated with age (r = 0.41, P < 0.0001), height (r = −0.21, P = 0.0006), body weight (r = −0.17, P = 0.007), mean blood pressure (r = 0.66, P < 0.0001), pulse pressure (r = 0.56, P < 0.0001), heart rate (r = 0.25, P < 0.0001), ln (ESR) (r = 0.20, P = 0.001), fasting blood glucose (r = 0.23, P = 0.0001), and ln (serum hsCRP) (r = 0.23, P = 0.0002). baPWV in the highest tertile of ESR was significantly higher than that in the lowest tertile of ESR (P = 0.005). baPWV in the highest tertile of serum hsCRP was significantly higher than those in the lowest tertile (P = 0.002) and the middle tertile of serum hsCRP (P = 0.02). In multiple regression analysis, baPWV significantly correlated with ln (serum hsCRP) independently of other clinical variables that showed a significant correlation with baPWV.baPWV is significantly associated with serum levels of hsCRP in Japanese men, suggesting that inflammation is involved in arterial stiffening. (Int Heart J 2006; 47: 409-420) Key words: Arterial stiffness, Pulse wave velocity, Blood pressure, High-sensitivity, Creactive protein, Erythrocyte sedimentation rate, Inflammation PULSE wave velocity (PWV) is an indicator of arterial stiffness 1-3) and a reliable marker of vascular damage. 4,5) So far, a number of studies have demonstrated that PWV obtained by noninvasive automatic devices is not only a marker of vascular From the Departments of

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“…In addition, three different groups found no significant correlation between smoking status and increased cfPWV. [41][42][43] However, AIx was increased in smokers (17.25%) compared with nonsmokers (11.75%; P¼0.004) in one of the same subject Smoking and arterial stiffness RJ Doonan et al Smoking and arterial stiffness RJ Doonan et al populations. 42 A number of other studies found AIx to be increased in chronic smokers compared with nonsmokers.…”

Section: Chronic Smokingmentioning

confidence: 97%

The effect of smoking on arterial stiffness

et al. 2010

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A systematic literature review was conducted using PubMed, Embase and the Cochrane Library to determine the effect of acute, chronic and passive smoking on arterial stiffness and to determine whether these effects are reversible after smoking cessation. A total of 39 relevant studies were identified and included. Acute smoking was found to cause an acute increase in arterial stiffness. Similarly, passive smoking increased arterial stiffness acutely and chronically. The majority of studies identified chronic smoking as a risk factor for increasing arterial stiffness. However, some studies found no statistical difference in arterial stiffness between nonsmokers and long-term smokers, although chronic smoking seems to sensitize the arterial response to acute smoking. In addition, whether arterial stiffness is reversed after smoking cessation and the timeline in which this may occur could not be determined from the identified literature. The effect of smoking discontinuation on arterial stiffness remains to be established by prospective smoking cessation trials.

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Relations of cardiovascular risk factors to aortic pulse wave velocity in asymptomatic middle-aged women

Cited by 99 publications

References 35 publications

Comparison of risk factors for vascular disease in the carotid artery and aorta in women with systemic lupus erythematosus

Comparison of risk factors for vascular disease in the carotid artery and aorta in women with systemic lupus erythematosus

Relationship Between Markers of Inflammation and Brachial-Ankle Pulse Wave Velocity in Japanese Men

The effect of smoking on arterial stiffness

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