Relations of inflammatory markers to lipid levels and autonomic tone in patients with moderate and severe chronic kidney disease and in patients under maintenance hemodialysis

Sn, Psychari; Sinos, Loukas; Iatrou, Christos; Liakos, G.; Ts, Apostolou

doi:10.5414/cnp64419

Cited by 20 publications

(18 citation statements)

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“…This finding is in line with previous studies showing that decreased HRV was associated with elevated IL-6 levels in patient populations (Aronson et al, 2001;Janszky et al, 2004;Psychari et al, 2005). Particularly, the bivariate association between LF power and IL-6 levels (r=-0.35 vs. r=-0.27) and between HF power and IL-6 levels (r=-0.39 vs. r=-0.16) seemed somewhat stronger in our healthy subjects than in a previous study on women with CAD (Janszky et al, 2004).…”

Section: Discussionsupporting

confidence: 93%

“…Taken together, we showed that decreased HRV is independently associated with elevated plasma IL-6 levels in reasonably healthy subjects as has been shown in patient populations (Aronson et al, 2001;Janszky et al, 2004;Psychari et al, 2005). We further found an independent relationship between plasma levels of IL-6 and sTF which have previously predicted an increased risk of future atherothrombotic events in apparently healthy individuals (Keller et al, 2006;Ridker et al, 2000).…”

Section: Discussionsupporting

confidence: 85%

“…Because the vagus nerve inhibits production of proinflammatory cytokines in peripheral tissues via a cholinergic anti-inflammatory pathway (Tracey, 2002), one mechanism that could link decreased HRV with atherosclerosis is by kindling low-grade systemic inflammation (Gidron et al, in press;Thayer and Lane, 2007). In accordance with this notion, HRV was inversely associated with circulating levels of the proinflammatory cytokine interleukin (IL)-6 in patients with chronic kidney disease (Psychari et al, 2005), CAD (Janszky et al, 2004), and decompensated chronic heart failure (Aronson et al, 2001). IL-6 plays a central role in the pathogenesis of CAD morbidity and mortality by promoting atherosclerotic plaque proliferation and instability, thereby ultimately increasing the risk of plaque rupture (Lobbes et al, 2006;Ridker et al, 2000).…”

Section: Introductionmentioning

confidence: 98%

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Relationship between heart rate variability, interleukin-6, and soluble tissue factor in healthy subjects

Känel

Nelesen

Mills

et al. 2008

Brain, Behavior, and Immunity

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Decreased heart rate variability (HRV) has been associated with an increased risk of atherosclerosis. We hypothesized that a decrease in frequency domains of resting HRV would be associated with elevated plasma levels of interleukin (IL)-6 and soluble tissue factor (sTF) both previously shown to prospectively predict atherothrombotic events in healthy subjects. Subjects were 102 healthy and unmedicated black and white middle-aged men and women. We determined IL-6 and sTF antigen in plasma and HRV measures from surface electrocardiogram data using spectral analysis. All statistical analyses controlled for age, gender, ethnicity, smoking status, blood pressure, and body mass index. Low amounts of low frequency (LF) power (β=-0.31, p=0.007) and high frequency (HF) power (β=-0.36, p=0.002) were associated with increased amounts of IL-6, explaining 7% and 9% of the variance, respectively. Interactions between LF power and IL-6 (p=0.002) and between HF power and IL-6 (p=0.012) explained 8% and 5%, respectively, of the variance in sTF. Post hoc analyses showed associations between IL-6 and sTF when LF power (β=0.51, p<0.001) and HF power (β=0.48, p<0.001) were low but not when LF power and high HF power were high. The findings suggest that systemic low-grade inflammatory activity is associated with a decrease in HRV. Furthermore, there was a positive relationship between plasma levels of IL-6 and sTF antigen when HRV was low. Inflammation and related hypercoagulability might particularly contribute to atherothrombotic events in a setting of decreased HRV.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Relationship between heart rate variability, interleukin-6, and soluble tissue factor in healthy subjects

Känel

Nelesen

Mills

et al. 2008

Brain, Behavior, and Immunity

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“…This relationship has also been documented in patients with sepsis [20] and decompensated heart failure [21] . Previous study found that lower autonomic tone (VLF and LF band) was associated with inflammation in patients with moderate to severe CKD patients but not in hemodialysis patients [22] . The decrease of autonomic activity in these patients may be a result of neural injury.…”

Section: Discussionmentioning

confidence: 81%

Synergic Impact of Vascular Calcification and Low Autonomic Tone in Mortality of Hemodialysis Patients

Hsueh²,

Lee³

et al. 2017

Nephron

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Background: Both cardiovascular calcification and autonomic dysfunction are frequently encountered in hemodialysis patients. We aimed to investigate the relationship between cardiovascular calcification and heart rate variability (HRV) and their influence on long-term outcome. Methods: Seventy-eight hemodialysis patients underwent echocardiogram and radiography of the pelvis and hands to identify valvular and vascular calcification. HRV was evaluated using a commercial machine. Results: Based on the average, the patients were divided into higher and lower subgroups of high frequency (HF) and low frequency (LF) respectively. Patients with higher LF were younger and were found to have a lower proportion of diabetes. Their hemoglobin, albumin, and bone morphogenic protein (BMP)-7 levels were significantly higher and both high-sensitive C-reactive protein (hs-CRP) and osteoprotegerin levels were lower (all p < 0.05). In patients of the higher HF group, the proportion of diabetes was lower but they were found to have higher levels of BMP-7 and lower levels of hs-CRP, interleukin-6 (all p < 0.05). Significantly higher LF and HF were noted in patients without vascular calcification, but only hand artery (HA) calcification was negatively correlated with both LF and HF in multivariate analysis. Low LF and high hs-CRP were the independent predictors of mortality. Coexistence of low LF band and HA calcification was associated with the worse outcome. Conclusions: Abnormal autonomic nervous function was closely related to inflammation and mortality in hemodialysis patients. Calcification of HA was associated with autonomic dysfunction and patients with lower autonomic tone and HA calcification had the highest mortality rate in this population.

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“…As an example, in maintaining hemodialysis patients, lipid profile parameters were related to interleukin 6 (IL-6) [3]. Allograft recipients, by receiving a non-self organ, have an aditional mechanism of activation [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Chronic Inflammation and Glucidic-Lipidic Profile Disorders in Kidney Transplant Recipients

Tarța

Caldararu

Gliga

et al. 2016

Acta Medica Marisiensis

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Introduction: Chronic inflammation has a proven role in atherogenesis, lipid profile parameters being related to cytokine production. In kidney transplant recipients, interleukin 6 (IL-6) is significantly associated with graft-related outcomes and also alterations of cholesterol and triglyceride metabolism. The aim of this study was to investigate the relationship between chronic inflammation and glucidic-lipidic metabolism disorders in a group of patients with kidney transplantation as renal replacement therapy. Methods: A prospective observational study which enrolled thirtysix non-diabetic kidney transplant recipients was conducted in the Nephrology and Peritoneal Dialysis Department, County Clinic Hospital of Tirgu Mures. The study group was divided as following: recipients with serum IL-6 concentration higher than 3.8 pg/ml (group A) and IL-6 within the normal range (group B). Results: Allograft recipients with higher serum IL-6 had significant higher erytrocyte sedimentation rate(ESR, p=0.0067). Patients with over-the-range levels of IL-6 had significant higher levels of serum cholesterol and LDL-cholesterol respectively (p=0.0242 and p=0.0081). Serum Apo-B was also significant higher in Group A than Group B. Protein excretion was significant higher in patients from group A (p=0.0013). No statistical significant relationship could be proven between elevated levels of IL-6 and hbA1c, insulin and glycosuria disturbances in the two groups. Also, we found no statistical significant association between resistivity and pulsatility indices (both hilum and intragraft) or carotid intima media thickness. Conclusion: Serum interleukin 6 is related to lipid profile disorders and less to glucidic metabolism anomalies in non-diabetic kidney transplant recipients.

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Relations of inflammatory markers to lipid levels and autonomic tone in patients with moderate and severe chronic kidney disease and in patients under maintenance hemodialysis

Cited by 20 publications

References 0 publications

Relationship between heart rate variability, interleukin-6, and soluble tissue factor in healthy subjects

Relationship between heart rate variability, interleukin-6, and soluble tissue factor in healthy subjects

Synergic Impact of Vascular Calcification and Low Autonomic Tone in Mortality of Hemodialysis Patients

The Relationship Between Chronic Inflammation and Glucidic-Lipidic Profile Disorders in Kidney Transplant Recipients

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