Relationship among carotenoid production, copper bioremediation and oxidative stress in Rhodotorula mucilaginosa RCL-11

Irazusta, Verónica Patricia; Nieto-Peñalver, Carlos Gabriel; Cabral, María Eugenia Sesto; Amoroso, Maria Julia del R.; Figueroa, Lucía I. C. de

doi:10.1016/j.procbio.2013.04.006

Cited by 53 publications

(47 citation statements)

References 33 publications

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“…The important protective role of carotenoids in the oxidative stress response caused by reactive oxygen species has also been demonstrated in the alga Haematococcus pluvialis (Méndez-Álvarez et al 2000). A study demonstrated that a mutant, R. mucilaginosa RCL-11 strain, expressed three major carotenoids identified as torularhodin, torulene and carotene in major quantities (Irazusta et al 2013). Another mutant, R. glutinis no.…”

Section: Role Of Torulene and Torularhodin In Microorganismsmentioning

confidence: 95%

“…These other functions have been deduced from their presence in fungi and non-photosynthetic bacteria (Sakaki et al 2002). The most important physiological role of carotenoids in red yeasts may be as antioxidants in situations of high oxidative stress (Madhour et al 2005), and also as light-quenching pigments (Irazusta et al 2013). The important protective role of carotenoids in the oxidative stress response caused by reactive oxygen species has also been demonstrated in the alga Haematococcus pluvialis (Méndez-Álvarez et al 2000).…”

Section: Role Of Torulene and Torularhodin In Microorganismsmentioning

confidence: 99%

“…The most significant characteristic of carotenoids is the conjugated double bond system that determines their color and biological action (Irazusta et al 2013). Torulene, the major carotenoid of R. mucilaginosa, is an interesting carotenoid for industrial applications.…”

Section: Torulene and Torularhodinmentioning

confidence: 99%

“…On the other hand, systematic measurements with different carotenoids have suggested an optimal chain length for diverse functions, e.g., 11 double bonds for singlet oxygen quenching, 7 and 11 or 9 and 11 double bonds for photo bleaching protection, 10 or 9 and 11 double bonds for light harvesting function, and 7 double bonds for photon-to-current conversion (solar cell) (Zaidi et al 2013). Some carotenoids are precursors of vitamin A, which is formed by the enzymatic hydrolysis of the carotenoid molecule (Maldonade et al 2008;Irazusta et al 2013). Torularhodin has the requirement for provitamin A activity, i.e., a ring without substituents and a lateral polyene chain of 11 carbons (Maldonade et al 2008), and has an provitamin A activity which is 75% that of carotene (Simpson 1983).…”

Section: Antioxidant and Pro-vitamin A Activitymentioning

confidence: 99%

“…When yeast cultures were supplemented with H 2 O 2 alone, the main changes observed were related to the total carotenoid amount, the detection of the precursor γ-carotene, and inverted percentages between torularhodin and torulene. It is, therefore, possible that this stressor not only induces the changes in the amounts of the carotenoids, but also in a specific carotenoid response (Irazusta et al 2013). A problem for the maximization of biosynthesis of a specific ketocarotenoid is the formation of byproducts.…”

Section: Production Of Torulene and Torularhodinmentioning

confidence: 99%

See 4 more Smart Citations

Torularhodin and Torulene: Bioproduction, Properties and Prospective Applications in Food and Cosmetics - a Review

Zoz

Carvalho

Soccol

et al. 2015

Braz. arch. biol. technol.

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Section: Role Of Torulene and Torularhodin In Microorganismsmentioning

confidence: 95%

Section: Role Of Torulene and Torularhodin In Microorganismsmentioning

confidence: 99%

Section: Torulene and Torularhodinmentioning

confidence: 99%

Section: Antioxidant and Pro-vitamin A Activitymentioning

confidence: 99%

Section: Production Of Torulene and Torularhodinmentioning

confidence: 99%

See 3 more Smart Citations

Torularhodin and Torulene: Bioproduction, Properties and Prospective Applications in Food and Cosmetics - a Review

Zoz

Carvalho

Soccol

et al. 2015

Braz. arch. biol. technol.

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The Effect of Zn(II) Ions and Reactive Oxygen on the Uptake of Zinc and Production of Carotenoids by Selected Red Yeasts

Breierová

Čertı́k

Márová

et al. 2018

Chemistry & Biodiversity

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Three strains of red yeast Rhodosporidium kratochvilovae, Rhodotorula glutinis and Sporidiobolus salmonicolor were studied for their responses to the presence metal stress, oxidative stress and a combination of these stress factors. For all yeast strains, the production of β-carotene increased in stress conditions. The combination of H O and Zn significantly activated the pathways for the production of torularhodin in the strain R. glutinis (from 250 to 470 μg g DCW) as well as β-carotene (from 360 to 1100 μg g DCW) and torulene (from 100 to 360 μg g DCW) in Sp. salmonicolor. Strains of R. glutinis and Rh. kratochvilovae bound the majority of Zn(II) ions to the fibrillar part of the cell walls, whereas the strain Sp. salmonicolor bound them to both extracellular polymers and the fibrillar part of the cell walls. A decrease in the ability of yeasts to tolerate higher concentrations of Zn(II) in the presence of free radicals (hydrogen peroxide) was also found.

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Rhodotorula mucilaginosa A8, a potential helper strain in a vitamin C microbial fermentation process

Zhang,

Liao,

Lyu

2024

J Basic Microbiol

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In the vitamin C microbial fermentation system, oxidative stress limits the growth and 2‐keto‐l‐gulonic acid (2‐KLG, the precursor of vitamin C) production of Ketogulonicigenium vulgare. Most Bacillus strains, as helper strains, have been reported to release key biomolecules to reduce oxidative stress and promote the growth and 2‐KLG production of K. vulgare. To understand the specific mechanism by which the helper strain and K. vulgare interact to reduce oxidative stress, a novel helper strain, Rhodotorula mucilaginosa A8, was used to construct a consortium in the co‐culture fermentation system. Based on the activities of the antioxidant enzymes and quantitative polymerase chain reaction (qPCR) analysis, R. mucilaginosa A8 could reduce oxidative stress and increase 2‐KLG production in K. vulgare by upregulating antioxidant enzyme activities and related gene‐expression levels. In addition, the carotenoids of R. mucilaginosa promoted 2‐KLG production in K. vulgare. Coculture of R. mucilaginosa with K. vulgare increased the yield of carotenoids. This study suggested that helper strains with the ability to reduce oxidative stress in K. vulgare would likely act as potential helper strains for facilitating 2‐KLG biosynthesis. This work could provide a theoretical basis for the search for potential helper strains for vitamin C microbial fermentation and for the construction of synthetic microbial communities to produce valuable products.

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Relationship among carotenoid production, copper bioremediation and oxidative stress in Rhodotorula mucilaginosa RCL-11

Cited by 53 publications

References 33 publications

Torularhodin and Torulene: Bioproduction, Properties and Prospective Applications in Food and Cosmetics - a Review

Torularhodin and Torulene: Bioproduction, Properties and Prospective Applications in Food and Cosmetics - a Review

The Effect of Zn(II) Ions and Reactive Oxygen on the Uptake of Zinc and Production of Carotenoids by Selected Red Yeasts

Rhodotorula mucilaginosa A8, a potential helper strain in a vitamin C microbial fermentation process

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