Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

Abstract

Chronic diarrhea, including diarrhea‐predominant irritable bowel syndrome (IBS‐D), osmotic diarrhea, bile acid diarrhea, and antibiotic‐associated diarrhea, is a common problem which is highly associated with disorders of the gut microbiota composition such as small intestinal bacterial overgrowth (SIBO) and so on. A growing number of studies have supported the view that Chinese herbal formula alleviates the symptoms of diarrhea by modulating the fecal microbiota. Chinese herbal polysaccharides (CHPs) are natural polymers composed of monosaccharides that are widely found in Chinese herbs and function as important active ingredients. Commensal gut microbiota has an extensive capacity to utilize CHPs and play a vital role in degrading polysaccharides into short‐chain fatty acids (SCFAs). Many CHPs, as prebiotics, have an antidiarrheal role to promote the growth of beneficial bacteria and inhibit the colonization of pathogenic bacteria. This review systematically summarizes the relationship among gut microbiota, chronic diarrhea, and CHPs as well as recent progress on the impacts of CHPs on the gut microbiota and recent advances on the possible role of CHPs in chronic diarrhea.

Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota

“…In recent years, studies have shown that the extracts of medicinal plant active ingredients, including Chinese herbal polysaccharides, have been playing a positive role in livestock production and disease prevention and treatment (12). Chinese herbal polysaccharide can play a variety of biological functions (36,37), such as antiinflammatory (38), anti-tumor (39), antioxidant, lowering blood sugar, lowering blood lipids (40), immune regulation (41), and regulating intestinal flora (42), etc. Chen et al found that the basal diet supplemented with 1,000 mg/kg Lonicera fulvotomentosa extract could significantly increase the final weight of weaned piglets and the diversity and richness of intestinal flora in the jejunum and rectum.…”

Evaluation of probiotics in the treatment of hypothyroidism in early pregnancy combined with small intestinal bacterial overgrowth

“…Excessive growth of small intestine bacteria refers to the presence of excessive numbers of bacteria in the small bowel, which can cause gastrointestinal symptoms (Pimentel et al., 2020 ). Its clinical symptoms include malnutrition, abdominal distension, diarrhea, and abdominal pain (Chen et al., 2020 ; Xue et al., 2023 ) found that a quadruple probiotic combination consisting of Bifidobacterium infantis , Lactobacillus acidophilus , Enterococcus faecalis , and Bacillus cereus had anti‐inflammatory effects and could help repair damage of the intestinal barrier.…”