Relationship Among Placental Cadmium, Lead, Zinc, and Copper Levels in Smoking Pregnant Women

Kutlu, Türkan; Karagözler, Arife Alev; Gözükara, Engin M.

doi:10.1385/bter:114:1:7

Cited by 29 publications

(18 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, ceruloplasmin is extremely important in the absorption and metabolism of iron, zinc, and copper in humans. However, smoking is reported to reduce serum levels of ceruloplasmin, erythrocyte Cu, and Zn SOD [43]. Differences in the mean rural male Cu level (897±249 μg/L) were observed to be significant compared to their female rural counterparts (1,063±367 μg/L).…”

Section: Discussionmentioning

confidence: 89%

Serum Levels of Cu, Se, and Zn in Adult Rural/Urban Residents in Ghana: Paradigm Shift?

Asare

Nani

2009

Biol Trace Elem Res

View full text Add to dashboard Cite

Deficiencies in Cu, Se, and Zn impair one or more biochemical functions, and excess are associated with toxicity. Baseline studies on the Ghanaian population are scanty. The study was undertaken to determine whether significant rural/urban differences in the serum levels of Cu, Se, and Zn did exist. Forty males/60 females from rural and 50 males/50 females from urban Ghanaian communities were sampled. Serum Cu, Se, and Zn were determined using flame atomic absorption spectrometry. Cu level for rural and urban subjects was 997 +/- 333 and 979 +/- 290 microg/L, respectively (p = 0.68). However, Cu levels were significantly higher in the rural females (1,063 +/- 367 microg/L) than the rural males (898 +/- 249 microg/L; p = 0.0085). Se levels for rural/urban subjects were 97 +/- 36 and 87 +/- 31 microg/L, respectively (p = 0.03). Zn levels in the rural/urban subjects were 312 +/- 218 and 150 +/- 102 microg/L, respectively (p = 0.002). Additionally, Zn was significantly higher in rural females (428 +/- 204 microg/L) than the urban females (166 +/- 103 microg/L; p = 0.0002). Finally, Zn was significantly higher in rural females (428 +/- 204 microg/L) than males (172 +/- 116 microg/L; p = 0.0028). In conclusion, Cu, Se, and Zn were higher in the rural group compared to the urban group, and the generally low Zn levels were confirmed in another cohort follow-up study.

show abstract

Section: Discussionmentioning

confidence: 89%

Serum Levels of Cu, Se, and Zn in Adult Rural/Urban Residents in Ghana: Paradigm Shift?

Asare

Nani

2009

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…In general, different types of spectrometry were used, except in one case in which both Cd and Pb were determined using a hanging Hg drop electrode (Kutlu et al 2006) and in five studies in which Hg was measured using an unspecified Hg analyzer (Hsu et al 2007) or instrumental neutron activation analysis (Grant et al 2010; Horvat et al 1988; Llanos and Ronco 2009; Ward et al 1987). These details were not always provided (Karp and Robertson 1977).…”

Section: Resultsmentioning

confidence: 99%

“…We located 46 studies reporting placental levels of Cd; 17 of these had > 100 participants [see Supplemental Material, Table S3 (http://dx.doi.org/10.1289/ehp.1204952)]. The average level of Cd varied widely (Figure 2)—ranging from 1.2 ng/g in Shanghai (Yang et al 1997) to 53 ng/g in an urban area of the United States (Karp and Robertson 1977)—and was particularly high, with values >20 ng/g, in some groups of pregnant women from Japan (Tsuchiya et al 1984), Bangladesh (Kippler et al 2010), Turkey (Kutlu et al 2006), and Eastern Europe (Fagher et al 1993; Piasek et al 2001; Reichrtova et al 1998b; Stasenko et al 2010). …”

Section: Resultsmentioning

confidence: 99%

Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

Esteban-Vasallo¹,

Aragonés

Pollán

et al. 2012

Environ Health Perspect

156

View full text Add to dashboard Cite

Background: Placental tissue may furnish information on the exposure of both mother and fetus. Mercury (Hg), cadmium (Cd), and lead (Pb) are toxicants of interest in pregnancy because they are associated with alterations in child development.Objectives: The aim of this study was to summarize the available information regarding total Hg, Cd, and Pb levels in human placenta and possible related factors.Methods: We performed a systematic search of PubMed/MEDLINE, EMBASE, Lilacs, OSH, and Web of Science for original papers on total Hg, Cd, or Pb levels in human placenta that were published in English or Spanish (1976–2011). Data on study design, population characteristics, collection and analysis of placenta specimens, and main results were extracted using a standardized form.Results: We found a total of 79 papers (73 different studies). Hg, Cd, and Pb levels were reported in 24, 46, and 46 studies, respectively. Most studies included small convenience samples of healthy pregnant women. Studies were heterogeneous regarding populations selected, processing of specimens, and presentation of results. Hg concentrations > 50 ng/g were found in China (Shanghai), Japan, and the Faroe Islands. Cd levels ranged from 1.2 ng/g to 53 ng/g and were highest in the United States, Japan, and Eastern Europe. Pb showed the greatest variability, with levels ranging from 1.18 ng/g in China (Shanghai) to 500 ng/g in a polluted area of Poland.Conclusion: The use of the placenta as a biomarker to assess heavy metals exposure is not properly developed because of heterogeneity among the studies. International standardized protocols are needed to enhance comparability and increase the usefulness of this promising tissue in biomonitoring studies.

show abstract

“…They are significant carcinogens as well [10,[33][34][35][36][37][38]. Mothers who smoke also take additional toxic trace elements in their breast milk such as Cd and Pb [39,40]. Breastfeeding is more preferable and the best way for feeding the infants in the developing countries.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Aflatoxin M1 and Heavy Metal Levels in Mothers Breast Milk in Famagusta, Cyprus

Kunter

Hürer

Gülcan

et al. 2016

Biol Trace Elem Res

View full text Add to dashboard Cite

Breast milk contributes towards optimal nutrition for infants. However, studies showed that it can also contain different toxins and heavy metals, which reduce its health benefits. The aim of this study is to determine the level of contaminants such as aflatoxin M1 (AFM1), Pb, Cd, As, and Hg in breast milk samples from Famagusta, Cyprus. Correlations between moldy food consumption, smoking habits of the mothers, and contaminant levels in breast milk were also investigated. Breast milk samples from 50 lactating mothers in rural and urban areas of Famagusta District were analyzed for AFM1 by ELISA. Eighty percent of them were found to be contaminated with AFM1 with the mean measurement of 7.84 ± 1.72 ng/l. Socio-demographic status, moldy food consumption habits, and smoking status do not have any effect on the AFM1 levels observed in breast milk. Heavy metal levels in breast milk were examined by inductively coupled plasma mass spectrometry, and the mean measurements were1.19 ± 1.53 ppm for Pb, 0.73 ± 0.58 ppm for As, 0 ± 0.20 ppm for Hg, and 0.45 ± 0.23 ppm for Cd. This study indicates that the levels of these contaminants in breast milk samples obtained in Famagusta District are well within the acceptable levels. However, the presence of AFM1 and heavy metals still may pose risks for infant health.

show abstract

Relationship Among Placental Cadmium, Lead, Zinc, and Copper Levels in Smoking Pregnant Women

Cited by 29 publications

References 33 publications

Serum Levels of Cu, Se, and Zn in Adult Rural/Urban Residents in Ghana: Paradigm Shift?

Serum Levels of Cu, Se, and Zn in Adult Rural/Urban Residents in Ghana: Paradigm Shift?

Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

Assessment of Aflatoxin M1 and Heavy Metal Levels in Mothers Breast Milk in Famagusta, Cyprus

Contact Info

Product

Resources

About