Relationship among Systolic Blood Pressure, Serum Insulin and Leptin, and Visceral Fat Accumulation in Obese Children

Nishina, Masahiro; Kikuchi, Toru; Yamazaki, Hisashi; Kameda, Kensuke; Hiura, Makoto; Uchiyama, Makoto

doi:10.1291/hypres.26.281

Cited by 78 publications

(64 citation statements)

References 23 publications

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“…However, leptin has also been reported to have depressor effects; that is, leptin was shown to function as a diuretic/ natriuretic factor (39) and to induce a release of nitric oxide that opposes the pressor action (25). Although many epidemiologic researchers had studied the association of leptin with blood pressure and the sympathetic nervous system, these results were not consistent (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(40)(41)(42)(43)(44)(45). Our results may partly explain this diversity of findings.…”

Section: Discussionmentioning

confidence: 68%

A Positive Association between Leptin and Blood Pressure of Normal Range in Japanese Men

et al. 2006

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Section: Discussionmentioning

confidence: 68%

A Positive Association between Leptin and Blood Pressure of Normal Range in Japanese Men

et al. 2006

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“…[33][34][35][36][37][38][39] Thus, the main prognostic problem in obesity is to estimate accurately the quantity and distribution of fat in the body. Both CT and MRI have been used in children and adolescents for this purpose.…”

Section: Discussionmentioning

confidence: 99%

Comparison of ultrasonographic and anthropometric methods to assess body fat in childhood obesity

2006

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Background: Pattern of fat distribution rather than obesity is of importance for cardiovascular morbidity and mortality. The accurate measurement of total and regional fat mass requires sophisticated and often expensive methods that have limited applicability in the clinical setting. Objective: The aim of this study is to evaluate body fat distributions by ultrasound (US) as a gold standard method for measuring visceral, preperitoneal and subcutaneous fat layers and comparing with anthropometric results, and then to find the most reliable anthropometric measurement in childhood obesity. Materials and methods: Study group of 51 obese children (21 F, 30 M) (mean age7s.d.: 11.572.6 years) and control group of 33 non-obese children (17 F, 16 M) (mean age7s.d.: 12.272.7 years) were recruited for this study. Anthropometric measurements as body mass index (BMI), waist circumference (WC), waist/hip ratio (WHR), triceps and subscapular skinfold thicknesses were taken from all the participants. Abdominal preperitoneal (P), subcutaneous (S) fat at their maximum (max) and minimum (min) thickness sites, visceral (V), triceps (TrUS) and subscapular (SsUS) fat thicknesses were also measured ultrasonographically. Results: In the obese group, BMI was significantly correlated with US measurements of fat thicknesses, except Pmin and SsUS, whereas in the control group, BMI was significantly correlated with all US fat measurements. The relation of US measurements with skinfold thickness and WC was more significant in the control than in the obese group. No relation between WHR and US fat thickness measurements was found in both groups. Multiple regression analysis, using V as the dependent variable and anthropometric parameters, gender and the group as the independent variables, revealed BMI was the best single predictor of V (R 2 : 0.53). Conclusion: This study suggests that the validity of the anthropometric skinfold thickness in the obese children is low. Despite the limitations reported in the literature, in our study, BMI provides the best estimate of body fat. WHR in children and adolescents is not a good index to show intra-abdominal fat deposition.

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“…Essas evidências comprovam que o sobrepeso é um importante fator associado à hipertensão arterial na adolescência, no entanto, são escassos os estudos que utilizam a CC como medida de associação de risco para hipertensão arterial nessa fase, o que dificulta a comparabilidade dos dados do presente estudo. No Japão, crianças e adolescentes com sobrepeso apresentaram associação significante da gordura visceral, avaliada por método de imagem, com a PAS (30). No Sul do Brasil foi verificado, em adultos, que a CC foi melhor preditora que o IMC para determinar risco para hipertensão arterial (9).…”

Section: Alvarez Et Alunclassified

“…Uma limitação do estudo foi a utilização do manô-metro digital para avaliar pressão arterial que, apesar de ser considerado um método aceitável em pediatria (39) e ter sido utilizado, recentemente, para avaliar hipertensão arterial em crianças e adolescentes japoneses (30), pode apresentar limitação, sobretudo, na determinação da pressão diastólica e necessita ser calibrado com mais freqüência (39). Acredita-se, todavia, que esta limitação não tenha alterado significativamente os resultados do estudo, já que foi utilizada a metodologia específica para o aparelho.…”

Section: Alvarez Et Alunclassified

Associação das medidas antropométricas de localização de gordura central com os componentes da síndrome metabólica em uma amostra probabilística de adolescentes de escolas públicas

Alvarez

Vieira

Sichieri

et al. 2008

Arq Bras Endocrinol Metab

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Avaliou-se a associação entre medidas antropométricas de localização de gordura central: circunferências da cintura (CC) e abdominal (CA) e as razões cintura/quadril (RCQ) e cintura/estatura (RCE), independente do percentual de gordura corporal (%GC) e índice de massa corporal (IMC), com os componentes da síndrome metabólica (SM) em uma amostra probabilística de 610 (222 meninos e 388 meninas) adolescentes de 12 a 19 anos de escolas públicas de Niterói, RJ. Foram avaliados glicose e perfil lipídico pelo método enzimático automatizado, insulina pela técnica de radioimunoensaio, %GC pela bioimpedância elétrica e a pressão arterial sistólica (PAS) e diastólica com manômetro digital. A associação entre as medidas antropométricas foi verificada por meio de regressão linear múltipla, com ajuste para IMC, %GC e idade. Nos meninos, a associação positiva entre CC (b = 1,03, p < 0,01) e RCE (b = 2,33, p < 0,05; b = 2,12 e p < 0,01) com triglicerídios foi mantida independente de IMC e % de GC, respectivamente. A CC se correlacionou com a PAS independente do %GC, tanto nos meninos (b = 0,70 p < 0,01) quanto nas meninas (b = 0,68 p < 0,01). Conclui-se que a CC foi a medida de gordura central que apresentou a melhor associação com os componentes da SM nos adolescentes.

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Relationship among Systolic Blood Pressure, Serum Insulin and Leptin, and Visceral Fat Accumulation in Obese Children

Cited by 78 publications

References 23 publications

A Positive Association between Leptin and Blood Pressure of Normal Range in Japanese Men

A Positive Association between Leptin and Blood Pressure of Normal Range in Japanese Men

Comparison of ultrasonographic and anthropometric methods to assess body fat in childhood obesity

Associação das medidas antropométricas de localização de gordura central com os componentes da síndrome metabólica em uma amostra probabilística de adolescentes de escolas públicas

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