Relationship between 25-hydroxyvitamin D and metabolic syndrome among Jordanian adults

Abstract

Evidence of the association between 25-hydroxyvitamin D (25(OH)D) and metabolic syndrome (MeS) remains uncertain and incongruent. This study aimed to determine the association between 25(OH)D and MeS among Jordanian adults. A complex multistage sampling technique was used to select a national population-based household sample. The present report deals exclusively with adults aged > 18 years who had complete information on all components of MeS (n = 3,234). A structured questionnaire was used to collect all relevant information. Anthropometric, clinical, and laboratory measurements were obtained. MeS was defined according to the International Diabetes Federation (IDF) definition. Of the total, 42.0% had MeS and 31.7% had 25(OH)D < 30 ng/ml. In a stratified analysis, the prevalence of MeS did not differ significantly between subjects with low and normal 25(OH)D levels for men and women in all age groups. In the multivariate analysis, the odds of MeS were not significantly different between subjects with low and normal 25(OH)D levels (OR = 0.85, 95% CI: 0.70, 1.05, P-value = 0.133). The association between 25(OH)D and MeS remained non-significant when 25(OH)D was analyzed as a continuous variable (OR = 1.004, 95% CI; 1.000, 1.008, P = 0.057) and when analyzed based on quartiles. None of the individual components of MeS were significantly associated with 25(OH)D level. This study does not provide evidence to support the association between 25(OH)D level and MeS or its individual components. Prospective studies are necessary to better determine the roles of 25(OH)D levels in the etiology of MeS.

Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan, Iran

“…Although the exact mechanisms linking 25(OH)D insufficiency with hyperglycaemia and subsequent diabetes risk are not completely understood, there is accumulating evidence that 25(OH)D may directly influence pancreatic b-cell secretory function through nuclear 25(OH)D receptors and may influence insulin sensitivity through insulin receptors' expression regulation of intracellular calcium (28) . The finding of no significant associations between serum 25(OH)D and other components of MetS, including WC, serum TAG, serum HDL-C and BP, in our study is similar to the results of studies conducted on women in Iran and on adults (men and women) in Jordan (27,38) . Another study performed among adolescents of French origin in Canada failed to reveal an association between serum 25(OH)D and the existence of at least two components of MetS (60) .…”

“…Apart from its necessity for bone metabolism, vitamin D has multiple extraskeletal beneficial effects (12,26) . Vitamin D plays a role in glucose homeostasis, insulin secretion and action, and regulation of lipolysis (18,21,23,27,28) . Low levels of serum 25(OH)D have been linked to some chronic diseases, including the metabolic syndrome (MetS), diabetes mellitus, CVD, myocardial infarction, peripheral arterial disease, hypertension, multiple *Corresponding author: Email saadatkarimi63@gmail.com r The Authors 2013 sclerosis and cancers (29)(30)(31)(32)(33)(34)(35)(36)(37) .…”

Body composition and metabolic profile in adults with vitamin D deficiency

“…However, such association is still controversial since some studies did not find a relationship between metabolic syndrome and vitamin D deficiency [15,16]. On the other hand, other studies have shown an inverse correlation between vitamin D and metabolic syndrome components [14,44,45].…”

“…Disagreement among results has also been found in studies on metabolic syndrome components. Some studies have reported an inverse association between 25OHD and a number of metabolic syndrome components [14], whereas others did not find the same results [15,16].…”

The relationship between metabolic syndrome and increase of metabolic syndrome score and serum vitamin D levels in Korean adults: 2012 Korean National Health and Nutrition Examination Survey

“…However, the association of metabolic syndrome and vitamin D is still being debated because the findings vary across studies. That is, some report that metabolic syndrome and its components are associated with vitamin D. ( 22 – 24 ) Some state that metabolic syndrome was not associated with vitamin D but that the components of metabolic syndrome are associated with vitamin D. ( 25 ) Finally, some report that neither metabolic syndrome nor its components was associated with vitamin D. ( 26 , 27 ) The Republic of Korea is experiencing an increasing prevalence of diseases such as metabolic syndrome, cardiovascular diseases, and vitamin D deficiency. However, research on the association between metabolic syndrome and vitamin D in Korean adults is scarce.…”