Relationship between 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas

Houghton, Janet A.; Weiss, Karen D.; Williams, Larry G.; Torrance, Pamela M.; Houghton, Peter J.

doi:10.1016/0006-2952(86)90281-9

Cited by 43 publications

(20 citation statements)

References 20 publications

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“…Cells (5x10 6 ) in 0.2 ml were injected subcutaneously into nude mice. Two weeks after inoculation (indicating as day 0) in the right thigh, the tumor size reached ~250-400 mm 3 . The animals were randomized on day 0 of treatment to control and treated groups (5 mice each/ group) to adjust mean tumor volume of each group.…”

Section: Human Esophageal Squamous Cell Carcinoma Cell Line (Te-2)mentioning

confidence: 99%

“…The tumor size was measured with calipers 3 times a week over a period of 5 weeks. The tumor volume was calculated according to the (length x width 2 )/2 and presented as the mean (± standard deviation) mm 3 .…”

Section: Human Esophageal Squamous Cell Carcinoma Cell Line (Te-2)mentioning

confidence: 99%

“…Neoadjuvant cytoreduction treatments are frequently used for the purpose of tumor downstaging, increasing the resection rate, and possibly improving survival (2). Although the combined treatment of radiation and anti-cancer drugs is a widely used therapeutic strategy, no satisfactory treatment regimen has yet been devised due to severe side effects and the acquisition of resistance (3)(4)(5). A new effective combined treatment strategy is a necessity for improving the therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

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Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Kitabayashi

Shimada²,

Yamada³

et al. 2006

Oncol Rep

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Abstract. Heavy carbon-ion beam therapy has revealed several potential advantages over X-rays. Heavy-ion therapy has been applied for various solid tumors including esophageal squamous cell carcinoma (SCC). Although the local control rate of carbon ion radiotherapy for esophageal cancer has revealed better rates than that of conventional radiotherapy, some patients have shown resistance to the treatment. No study has evaluated whether anti-cancer drugs can enhance the anti-tumor effect of heavy carbon-ion beam irradiation. Therefore, we evaluated the efficacy of docetaxel, fluorouracil, cisplatinum, doxorubicin and gemcitabine to enhance the anti-tumor effects of heavy carbon-ion beam irradiation on human esophageal SCC cells in both in vitro and in vivo experiments. Fluorouracil, cisplatinum, doxorubicin and gemcitabine showed only additive anti-tumor effects. On the other hand, growth suppression was significantly potentiated by the combined treatment with heavy carbon-ion beam and docetaxel as compared to that treated with either agent alone. These data suggest that heavy carbon-ion beam irradiation combined with docetaxel may be a potentially useful therapeutic strategy for locally advanced esophageal SCC.

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Section: Human Esophageal Squamous Cell Carcinoma Cell Line (Te-2)mentioning

confidence: 99%

Section: Human Esophageal Squamous Cell Carcinoma Cell Line (Te-2)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Kitabayashi

Shimada²,

Yamada³

et al. 2006

Oncol Rep

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“…Although combination therapy of radiation and chemotherapy is used most widely, a satisfactory treatment has not yet been established due to severe side e ects and resistance acquisition (Houghton et al, 1986;Aschele et al, 1992). Cancer gene therapy using p53 has been developed as an alternative to conventional therapy (Roth et al, 1996) because mutations in this gene are found in more than 50% of esophageal cancers (Hollstein et al, 1990;Bennett et al, 1992;Nabeya et al, 1995;Kobayashi et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33ING1 in T.Tn human esophageal carcinoma cells

et al. 2002

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To investigate the e ect of p33 ING1 on wild-type p53 gene therapy, T.Tn human esophageal carcinoma cells were stably transfected with p33 ING1 cDNA. Infection with Adp53 (recombinant adenovirus containing wild-type p53) into p33-transfected cells reduced cell viability, while infection with empty vector had little e ect. This reduced viability was shown to be due to apoptotic cell death by the TUNEL (terminal deoxynucleotidyl transferasemediated nick end-labeling) assay. Following infection with Ad-p53, levels of p53 were similar in p33-expressing cells and in the parental line. However, levels of p21 and Mdm2 were elevated in p33-transfected cells. Nonetheless, this enhanced expression of Mdm2 appeared to be ine ective in downregulating p53. Transient transfection with mutant Mdm2 prior to Ad-p53 infection provided a signi®cant protection as compared with cells transfected with wild-type Mdm2. These results imply a synergistic e ect between p33 and p53 in the induction of apoptosis of human esophageal carcinoma cells. A role for Mdm2 in this synergism is suggested.

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“…2 As surgical resection alone rarely results in long -term survival, efforts are now focused on combined multimodality treatments in an attempt to improve local control and eliminate micrometastases present at the time of surgery. Although the combination of radiation and anticancer drugs, 5 -fluorouracil (5 -FU ) 3 and cisplatinum, is most frequently used in the current therapy, therapeutic efficacy has not been satisfactory established due to their side effects 4 and the acquisition of resistance. 5 Resistance to 5-FU is associated with reinforcement of phosphorylation 6,7 and reduced activity levels of enzymes involved in pyrimidine nucleotide synthesis.…”

mentioning

confidence: 99%

Enhanced growth suppression in esophageal carcinoma cells using adenovirus-mediated fusion gene transfer (uracil phosphoribosyl transferase and herpes simplex virus thymidine kinase)

et al. 2001

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Relationship between 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas

Cited by 43 publications

References 20 publications

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33ING1 in T.Tn human esophageal carcinoma cells

Enhanced growth suppression in esophageal carcinoma cells using adenovirus-mediated fusion gene transfer (uracil phosphoribosyl transferase and herpes simplex virus thymidine kinase)

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