Relationship between 5-HTTLPR polymorphism and post-stroke depression

Guo, Weiyun; Zhang, Z. H.; Mu, Junlin; Liu, D.; Zhao, Lin; Yao, Zhenwei; Song, Jinggui

doi:10.4238/gmr.15017460

Cited by 19 publications

(31 citation statements)

References 22 publications

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“…The elevation of IL-6 in patients that have strokes could possibly predict the development of poststroke depression [23,24]. In another meta-analysis, brain-derived neurotrophic factor (BDNF) was found to be involved in the development of depression and poststroke depression [25,26]. In these studies, a low serum level of BDNF in the acute phase after a stroke was associated with the development of poststroke depression.…”

Section: Biomarkers Associated With Poststroke Depressionmentioning

confidence: 99%

“…BDNF is inherently involved in hippocampal plasticity and memory [27]. One study found a significant negative relationship between BDNF and NIHSS [25][26][27]. In rodent models, low levels of BDNF in the hippocampus that had an acute stroke exhibited depressed behavior, however if BDNF was overexpressed there was a marked decrease in depressed behavior [21].…”

Section: Biomarkers Associated With Poststroke Depressionmentioning

confidence: 99%

“…In rodent models, low levels of BDNF in the hippocampus that had an acute stroke exhibited depressed behavior, however if BDNF was overexpressed there was a marked decrease in depressed behavior [21]. Increased BDNF in the rodent model also resulted in reduced infarct size and improved functionality of the rodent [25].…”

Section: Biomarkers Associated With Poststroke Depressionmentioning

confidence: 99%

“…There have also been studies that have shown a genetic contribution to poststroke depression. Multiple studies have evaluated the 5-HT gene located on New Insight into Cerebrovascular Diseases -An Updated Comprehensive Review 6 chromosome 17q11.1-17q12, which encodes the serotonin transporter [25][26][27]. In a meta-analysis of 7 studies, there was a significant relationship between 5-HTTLPR polymorphism and the development of poststroke depression symptoms.…”

Section: Genetic Association With Poststroke Depressionmentioning

confidence: 99%

“…In a meta-analysis of 7 studies, there was a significant relationship between 5-HTTLPR polymorphism and the development of poststroke depression symptoms. 5-HTTLPR is an exon of the 5-HT transporter gene polymorphism [25,26]. The hypothesis is that this gene polymorphism responds to the increased activity of the amygdala when responding to negative stimuli.…”

Section: Genetic Association With Poststroke Depressionmentioning

confidence: 99%

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Post Stroke Depression

Singh¹,

Pandhi²,

Alexandrov³

2020

New Insight Into Cerebrovascular Diseases - An Updated Comprehensive Review

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Depression is the most common neuropsychiatric disorder affecting over one third of all stroke patients. The presence of depression after a stroke greatly affects the ability of patients to participate in rehabilitation and can even affect their long-term mortality. Poststroke depression is a well-documented and studied aspect of stroke management because of the implications it has on morbidity, mortality and recovery. Despite post stroke depression being a well-studied phenomenon, it remains underdiagnosed. The development of poststroke depression is multifactorial and has been evaluated from the cellular, genetic, and environmental perspective. Using numerous studies this chapter will review facets of post stroke depression such as epidemiology, etiology and treatment, while evaluating how this phenomena effects patient recovery and rehabilitation.

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