Relationship between a genetic predisposition to hypertension, blood pressure levels and pain sensitivity

Guasti, Luigina; Gaudio, Giovanni; Zanotta, Danilo; Grimoldi, Paola; Petrozzino, M; Tanzi, Fabio; Bertolini, A; Grandi, Anna Maria; Venco, Achille

doi:10.1016/s0304-3959(99)00059-7

Cited by 42 publications

(26 citation statements)

References 43 publications

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“…Specifically, reduced sensitivity to a variet5r of naturally occurring and laboratory pain stimuli has been observed in individuals with hypertension [16][17][18][22][23][24]39 -42,47,571, high-normal blood pressure {2,9, '17,27,29,33,46), and a family history of hypertension. [1,5,10,11,13,30,33].…”

Section: Introductionmentioning

confidence: 99%

Maternal family history of hypertension attenuates neonatal pain response

Taddio

Shah

Pagé

et al. 2009

Pain

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Reduced sensitivity to naturally occurring and laboratory pain stimuli has been observed in individuals with hypertension, high-normal blood pressure, and a family history of hypertension. The present study sought to extend these findings by examining the relationship between familial history of hypertension and pain responsivity in neonates. Eighty infants had intramuscular (lM) injections of vitamin K p€r-formed in the delivery room within t h ofbirth as per institutional practice. Video recordings ofthe injection procedure were used by trained observers to code infant pain responses using facial grimacing and cry duration. Prior to the birth ofthe child, the infants'parents each completed a family blood pressure history survey and these responses were used to identifu infants with and without a maternal and paternal family history of hypertension. As compared to infants without a maternal family history of hypertension, infants with a maternal family history of hypertension had significantly shorter crying times, (1,74)=6.96, p=.O'1, q2 =.086, and marginally lower facial grimacing scores, F(1,74)=2.68, p=.16, 42 =.O3s, during vitamin K injection. The presence of attenuated responses to the IM injection in neonates with a maternal family history ofhypertension provides important and novel evidence that reduced pain responding in individuals at risk for hypertension is not a learned response st5de, but rather may arise from prenatal or genetic influences.

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Section: Introductionmentioning

confidence: 99%

Maternal family history of hypertension attenuates neonatal pain response

Taddio

Shah

Pagé

et al. 2009

Pain

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“…It has been established that, depending on the intensity of the external stimulus, touch and pain receptors may activate simultaneously 14 ; therefore, some prior research focused specifically on pain assessment may help explain the findings of the present study. Several studies have suggested that normotensive people are more sensitive to pain [21][22][23] and experience reductions in pain sensation after resistance training and aerobic exercise. [10][11][12] Koltyn and Arbogast 12 assessed the influence of resistance training on pain threshold and pain scores in young adults.…”

Section: Discussionmentioning

confidence: 99%

Efeito de uma sessão de exercício resistido na sensibilidade cutânea em idosas hipertensas e normotensas fisicamente ativas. 10.5007/1980-0037.2011v13n6p409

Ceccato

Ferreira

Filho

et al. 2011

Rev. Bras. Cineantropom. Desempenho Hum.

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-The aim of this study was to analyze the effect of a single session of resistance training on skin sensitivity in physically active, hypertensive and normotensive older women, as well as compare skin sensitivity in both groups. Thirty-two physically active women (mean age 65.8 ± 5.1 years; weight, 69.5 ± 13.7 kg; height, 1.60 ± 0.1 m) participated in this study and were classified as hypertensive (n = 15) or normotensive (n = 17). All participants answered a clinical history questionnaire and the Modified Baecke Questionnaire for Older Adults. Before and after the resistance training session, the skin sensitivity of the dominant hand was assessed at seven anatomical sites on the dorsal and palmar surfaces by stimulation with a Semmes-Weinstein monofilament esthesiometer. The loads employed during the resistance training session were determined one week before the experimental protocol. The Wilcoxon test showed no statistically significant differences in the skin sensibility test before and after resistance training in either groups. However, the Mann-Whitney U revealed a statistically significant between-group difference in sensitivity at three sites before resistance training and at only site post-training. A single session of resistance training had no effect on the skin sensitivity of hypertensive and normotensive older women. However, hypertensive participants exhibited reduced skin sensibility at some anatomical sites as compared with normotensive women. Key words: Aging; Hypertension; Tactile sense; Resistance training. (65,8 ± 5,1anos; 69,5 ± 13,7Kg;1,60 ± 0,1m) Resumo -O estudo teve como objetivo analisar o efeito de uma sessão de exercícios resistidos na sensibilidade cutânea em idosas hipertensas e normotensas fisicamente ativas, bem como comparar a sensibilidade cutânea entre os dois grupos. Participaram deste estudo 32 mulheres

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“…As described previously (Guasti et al, 1995;Guasti et al, 1999), a TAKEDA TM2421 (A and D Co) set to take one measure every 15 min for a 24-hour period was used. This instrument has a combined auscultatory and oscillometric method to minimize errors.…”

Section: Twenty-four Hour Ambulatory Blood Pressurementioning

confidence: 99%

“…The test quality was good (N80% valid measurements) in all the subjects. A computerized program did the reading and editing of the data (Guasti et al, 1995;Guasti et al, 1999). The 24-hour values of systolic and diastolic mean blood pressures were computed.…”

Section: Twenty-four Hour Ambulatory Blood Pressurementioning

confidence: 99%

“…Besides the invasive phenylephrine method (La Rovere et al, 1988), the baroreflex sensitivity may be studied non-invasively, using the spontaneous oscillations of heart rate and blood pressure expressed by the measure of the baroreflex gain (alphaLF; ms/mm Hg) (Pagani et al, 1988;Malliani et al, 1991;Newton et al, 2006;Radaelli et al, 2006;Smith et al, 2008) that can be extracted by the ratio between power spectral densities of the RR interval and SBP series. Therefore, calculating the RR-interval changes which occur in response to spontaneous variations of beat-to-beat SBP values in the frequency domain (after evaluation of the coherence between the systolic blood pressure and the electrocardiographic RR signals) (Robbe et al, 1987;Pagani et al, 1988;Malliani et al, 1991;Guasti et al, 1999), it is possible to investigate the baroreflex arc sensitivity in a non-stimulated state, showing higher LFalpha-index values associated with greater baroreflex sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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