Relationship between abnormal glucose tolerance test and history of previous recurrent miscarriages, and beneficial effect of metformin in these patients: a prospective clinical study

Zolghadri, Jaleh; Tavana, Zohreh; Kazerooni, Talieh; Soveid, Mahmood; Taghieh, Marzieh

doi:10.1016/j.fertnstert.2007.06.079

Cited by 54 publications

(26 citation statements)

References 20 publications

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“…In a prospective controlled clinical trial, metformin and placebo were given to women with an abnormal glucose tolerance test and who had recurrent miscarriage during the current pregnancy or previously. The miscarriage rate was significantly reduced (15 vs. 55%) for metformin and placebo, respectively [14]. Khattab et al [15] examined 120 patients who became pregnant while taking metformin and continued metformin use during pregnancy (experimental group) and 80 women who discontinued metformin use at the time of conception or during pregnancy (control group).…”

Section: Discussionmentioning

confidence: 99%

Relationship between Recurrent Miscarriage and Insulin Resistance

Wang¹,

Zhao²,

Li³

et al. 2011

Gynecol Obstet Invest

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Aims: To investigate the differences in insulin resistance between women with recurrent miscarriage and those with normal pregnancy. Methods: Pregnant women with a history of recurrent miscarriage were included in the patient group (n = 97), while those with no history of abnormal pregnancy were included in the control group (n = 52). Both groups consented to undertake an oral glucose tolerance test and insulin-releasing test between the 5th and 13th weeks of pregnancy. Results: (1) Levels of fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance index, and homeostasis model assessment β function were not statistically significantly different (p < 0.05) between the two groups. (2) The area under the curve of glucose and area under the curve of insulin were higher in the patient group than in the control group. The composite insulin sensitivity index of the patient group was lower than that of the control group. The differences in these three parameters between the groups were statistically significant (p < 0.05). Conclusion: Women with a history of recurrent miscarriage are at an increased risk for insulin resistance during the first trimester of a new pregnancy.

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Section: Discussionmentioning

confidence: 99%

Relationship between Recurrent Miscarriage and Insulin Resistance

Wang¹,

Zhao²,

Li³

et al. 2011

Gynecol Obstet Invest

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show abstract

“…In addition, metformin has been shown to be effective in an insulin-resistant PCOS woman with recurrent miscarriage (23), and it was also found that metformin therapy improved the chances of a successful pregnancy in PCOS patients with an abnormal glucose tolerance test and a history of recurrent miscarriage (74). Metformin is classified by the U.S. Food and Drug Administration under pregnancy category B, and no teratogenic effect has been demonstrated in humans (75)(76)(77).…”

Section: Figurementioning

confidence: 99%

“…Metformin is classified by the U.S. Food and Drug Administration under pregnancy category B, and no teratogenic effect has been demonstrated in humans (75)(76)(77). Furthermore, notwithstanding the reassuring preliminary data (19,20,23,59,73,74), in clinical practice metformin administration is usually discontinued during pregnancy in women who conceived during treatment.…”

Section: Figurementioning

confidence: 99%

Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

Palomba

Falbo

Orio

et al. 2009

Fertility and Sterility

120

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“…Some study groups published guidelines stating that suppressing high LH levels in cases with PCOS does not increase the rate of live birth, in 2003 and 2006 [11,12]. In spite of all these results, many recent researchers reported that giving metphormin to cases with PCOS and LH hyper-secretion in the first trimester of pregnancy increases the rate of live birth [13][14][15]. Hyperprolactinemia may also play a role in the etiology of recurrent abortion.…”

Section: Discussionmentioning

confidence: 99%