Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection

Rodríguez, Alejandro; Reyes, Luis Felipe; Monclou, J.; Suberviola, Borja; Bodí, M.; Sirgo, G.; Solé-Violán, J.; Guardiola, Juan; Barahona, D.; Díaz, Enrique; Martín‐Loeches, Ignacio; Restrepo, M.I.

doi:10.1016/j.medine.2017.12.011

Cited by 21 publications

(9 citation statements)

References 26 publications

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“…Another constituent in our risk score is PCT, which has been confirmed as a reliable maker for predicting AKI in many kinds of patients including those diagnosed with critically ill, traumatic injury, influenza infection or acute pancreatitis. [17][18][19][20][21] In our study, the single PCT level indeed had high predictive value with AUC of 0.881. The close correlation between PCT and AKI in COVID-19 patients may be mediated by the systemic inflammation.…”

Section: Discussionsupporting

confidence: 66%

“…15,16 Previous studies have found that serum PCT level was useful in predicting the development of AKI during hospitalization for many kinds of diseases including critically ill, traumatic injury, influenza infection, and acute pancreatitis. [17][18][19][20][21] However, the specific association between PCT and AKI in COVID-19 patients has not been explored. We designed this study to evaluate the value of PCT on predicting AKI in COVID-19 patients.…”

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confidence: 99%

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A risk score based on procalcitonin for predicting acute kidney injury in COVID‐19 patients

Wang

Kang

2021

Clinical Laboratory Analysis

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Section: Discussionsupporting

confidence: 66%

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confidence: 99%

A risk score based on procalcitonin for predicting acute kidney injury in COVID‐19 patients

Wang

Kang

2021

Clinical Laboratory Analysis

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“…Therefore, they can be used to differentiate between bacterial and viral infections (88). Higher PCT levels in the severe COVID-19 group indicate that critically ill patients may have concomitant bacterial infections (89).…”

Section: Discussionmentioning

confidence: 99%

Laboratory findings in coronavirus disease 2019 (COVID-19) patients: a comprehensive systematic review and meta-analysis

Karimian

Jamshidbeigi

Badfar

et al. 2020

Preprint

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BackgroundIn early December 2019, the first patient with COVID-19 pneumonia was found in Wuhan, Hubei Province, China. Recent studies have suggested the role of primary laboratory tests in addition to clinical symptoms for suspected patients, which play a significant role in the diagnosis of COVID-19. Therefore, the present study was conducted to evaluate laboratory findings in COVID-19 patients.Data SourcesPubMed/Medline, Scopus, EMBASE, Web of Science (ISI), Cochrane Library, Ovid, Science Direct, CINAHL and EBSCO.Study SelectionCross-sectional of adverse outcomes stratified by the status of ICLs were selected.Data ExtractionThe prevalence of available variables for laboratory tests were extracted.ResultsFinally, 52 studies involving 5490 patients with COVID-19 entered the meta-analysis process. The prevalence of leukopenia, lymphopenia, elevated c-reactive protein (CRP), elevated erythrocyte sedimentation rate (ESR), elevated serum amyloid A, elevated ferritin was estimated to be 20.9% (95%CI: 17.9-24.3), 51.6% (95%CI: 44.0-59.1), 63.6% (95%CI: 57.0-69.8), 62.5% (95%CI: 50.1-73.5), 63.6% (95%CI: 57.0-69.8), 62.5% (95%CI: 50.1-73.5), 74.7% (95%CI: 50.0-89.7), and 72.6% (95%CI: 58.1-83.5), respectively. The prevalence of elevated interleukin-6 was 59.9% (95%CI: 48.2-70.5), CD3 was 68.3% (95%CI: 50.1-82.2), reduced CD4 was 62.0% (95%CI: 51.1-71.6), reduced CD8 was 42.7% (95%CI: 32.2-53.9). The prevalence of elevated troponin-I was 20.6% (95%CI: 9.0-40.5), elevated creatine kinase-MB (CKMB) was 14.7% (95%CI: 7.1-28.0), elevated brain natriuretic peptide (BNP) was 48.9% (95%CI: 30.4-67.7), elevated blood urea nitrogen was 13.1% (95%CI: 6.6-24.4),, elevated creatinine was 7.2% (95%CI: 4.4-11.8), elevated lactate dehydrogenase (LDH) was 53.1% (95%CI: 43.6-62.4), hyperglycemia was 41.1% (95% CI: 28.2-55.5), elevated total bilirubin was 48.9% (95%CI: 30.4-67.7), reduced albumin was 54.7% (95%CI: 38.1-70.2), reduced pre-albumin was 49.0% (95%CI: 26.6-71.8), and reduced PT was 53.1% (95% CI: 43.6-62.4), and D-dimer was 44.9% (95%CI: 31.0-59.6).ConclusionThis study provides a comprehensive description of laboratory characteristics in patients with COVID-19. The results show that lymphopenia, elevated CRP, elevated ESR, elevated ferritin, elevated serum amyloid A, elevated BNP, reduced albumin, reduced pre-albumin, reduced CD3, reduced CD4, reduced CD8, elevated D-dimer, reduced PT, elevated interleukin-2, elevated interleukin-6, elevated LDH and hyperglycemia are the common findings at the time of admission.

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“…Literature on AKI in influenza suggests some risk factors common to both illnesses, such as those related to illness severity (e.g., critical illness, mechanical ventilation). 5 , 6 , 7 , 8 Similarly, elevated inflammatory markers have been observed in both influenza and COVID-19 and are often associated with AKI, 5 , 8 , 9 , 10 , 11 , 12 while histopathologic data and clinical studies suggest ischemic injury as the predominant etiology of AKI in both illnesses. 13 , 14 , 15 , 16 , 17 , 18 , 19 Further understanding of the relative and combined burden of AKI in these two illnesses is critical.…”

Section: Introductionmentioning

confidence: 93%

Comparison of COVID-19 versus influenza on the incidence, features, and recovery from acute kidney injury in hospitalized United States Veterans

Birkelo

Parr

Perkins

et al. 2021

Kidney International

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Acute kidney injury is a common complication in patients hospitalized with SARSCoV-2 (COVID-19), with prior studies implicating multiple potential mechanisms of injury. Although COVID-19 is often compared to other respiratory viral illnesses, few formal comparisons of these viruses on kidney health exist. In this retrospective cohort study, we compared the incidence, features, and outcomes of acute kidney injury among Veterans hospitalized with COVID-19 or influenza and adjusted for baseline conditions using weighted comparisons. A total of 3402 hospitalizations for COVID-19 and 3680 hospitalizations for influenza admitted between October 1, 2019 and May 31, 2020 across 127 Veterans Administration hospitals nationally were studied using the electronic medical record. Acute kidney injury occurred more frequently among those with COVID-19 compared to those with influenza (40.9% versus 29.4%, weighted analysis) and was more severe. Patients with COVID-19 were more likely to require mechanical ventilation and vasopressors and experienced higher mortality. Proteinuria and hematuria were frequent in both groups but more common in COVID-19. Recovery of kidney function was less common in patients with COVID-19 and acute kidney injury but was similar among survivors. Thus, findings from this study confirm that acute kidney injury is more common and severe among patients hospitalized with COVID-19 compared to influenza, a finding that may be driven largely by illness severity. Hence, the combined impact of these two illnesses on kidney health may be significant and have important implications for resource allocation.

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Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection

Cited by 21 publications

References 26 publications

A risk score based on procalcitonin for predicting acute kidney injury in COVID‐19 patients

A risk score based on procalcitonin for predicting acute kidney injury in COVID‐19 patients

Laboratory findings in coronavirus disease 2019 (COVID-19) patients: a comprehensive systematic review and meta-analysis

Comparison of COVID-19 versus influenza on the incidence, features, and recovery from acute kidney injury in hospitalized United States Veterans

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