Relationship Between Acute Phase Reactants and Disability in Guillian-Barré Syndrome During the COVID-19 Pandemic

Yevgi, Recep

doi:10.1016/j.arcmed.2021.10.002

Cited by 3 publications

(7 citation statements)

References 30 publications

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“…The most common type of electrophysiology pattern in GBS is AIDP 29 . During the COVID‐19 pandemic, the AMAN pattern was the most prevalent electrophysiologic result in our GBS patients (Table 9) and the level of WBC and ESR were significantly lower than the pre‐COVID‐19 pandemic (Table 8).…”

Section: Discussionmentioning

confidence: 82%

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The characteristics of Guillain–Barre syndrome in children in pre‐COVID‐19 and during the COVID‐19 pandemic: A cross‐sectional study

Javankiani,

Nasrollahizadeh,

Gharib

et al. 2023

Health Science Reports

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Background and AimsIn the pathophysiology of Guillain–Barre syndrome (GBS), inflammation and immunity are believed to play a key role. The neutrophil‐lymphocyte ratio (NLR), monocyte‐lymphocyte ratio (MLR), and platelet‐lymphocyte ratio (PLR) have been recently identified as potential markers of inflammation or immunity. This study aimed to investigate whether NLR, MLR, and PLR are associated with GBS characteristics in children. We also assessed the impact of the COVID‐19 pandemic on the characteristics of GBS in Iran.MethodsIn this retrospective cross‐sectional study, we reviewed the records of all 150 children diagnosed with GBS in the Children's Medical Center hospital affiliated with Tehran University of Medical Sciences (TUMS) from March 2017 until March 2022. The TUMS research ethics committee approved the study (Ethics code: IR.TUMS.CHMC.REC.1399.125). Patients' data including gender, age, clinical symptoms, laboratory findings, and electrodiagnostic study results were collected and analyzed.ResultsThis study involved 150 children, comprising 93 boys and 57 girls, with an average age of 7.53 ± 3.75 years. The analysis demonstrated that the number of hospitalization days increased with an increase in NLR (p = 0.025). Moreover, patients with abnormal electrodiagnostic study patterns had a higher risk of intensive care unit (ICU) admission (p: 0.027), although according to binary logistic regression, respiratory failure at admission time was the only significant factor increasing the risk of ICU admission (p = 0.035). The study also found that the pandemic has resulted in a shift from acute inflammatory demyelinating polyneuropathy to acute motor axonal neuropathy as the most common EMG‐NCV pattern in our patients (p < 0.001).ConclusionWe found that higher NLR was associated with a longer hospitalization duration and could potentially distinguish between severe and mild cases of GBS. We have also shown that the COVID‐19 pandemic has changed our patients' most frequent electromyography and nerve conduction velocity (EMG‐NCV) patterns.

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Section: Discussionmentioning

confidence: 82%

“…8 The most common type of electrophysiology pattern in GBS is AIDP. 29 During the COVID-19 pandemic, the AMAN pattern was the most prevalent electrophysiologic result in our GBS patients (Table 9)…”

Section: Covid-19 Pandemicmentioning

confidence: 94%

The characteristics of Guillain–Barre syndrome in children in pre‐COVID‐19 and during the COVID‐19 pandemic: A cross‐sectional study

Javankiani,

Nasrollahizadeh,

Gharib

et al. 2023

Health Science Reports

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“…Electrophysiological studies and CSF analysis help confirm the diagnosis and exclude other diseases. 22 High CSF protein level is a biomarker determining the severity and extent of the disease and is frequently used in diagnosing GBS. 23 Although not significant, the mean CSF total protein levels were higher in patients in the C-GBS group than the NC-GBS patients (135.87±53.66 vs. 132.14±83.73) in this study (p=0.140).…”

Section: Table 4: Covid-19-related Clinical Features Of Patients With...mentioning

confidence: 99%

Assessment of the relationship between COVID -19 and Guillain Barre syndrome: a single center pandemic experience

Bahtiyarca¹,

Karaahmet²,

Ateş³

et al. 2023

NeuroAsia

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Background & Objective: This study aimed to determine the relationship between COVID-19 infection/ vaccination and Guillain-Barré syndrome (GBS) and to compare clinical characteristics and functional outcomes between COVID-19-related and non-COVID-19 GBS patients. Method: The medical files of the patients who sought treatment with the diagnosis of GBS between March 2020 and July 2022 were retrospectively analyzed. The patients were divided into groups as COVID-19-related GBS (C-GBS) and non-COVID-19 GBS (NC-GBS). Demographic and clinical characteristics, neurological examination findings, treatment protocols, and outcomes, including functional status, ambulation level, independence in daily living activities, and anxiety-depression levels of the patients with GBS, were recorded. Results: A total of 25 patients were included in the study. GBS was found to be associated with COVID-19 in 9 (36%) patients. Among them, 5 (20%) patients developed GBS after COVID-19 infection and 4 (16%) after the COVID-19 vaccine. The latency between COVID-19 infection and the onset of GBS ranged from 7 to 60 days, and the latency between vaccination and the onset of GBS ranged from 3 to 60 days. The clinical presentation and features, disease severity, and electrodiagnostic patterns of C-GBS patients were similar to NC-GBS patients. Also, there was no significant difference between patients with C-GBS and NC-GBS regarding functional status, ambulation level, functional independence in daily activities, and anxiety-depression levels. Conclusion: GBS is not uncommon in COVID-19. In this study, 20% of GBS cases admitted to our hospital during the pandemic seem to be associated with COVID-19 infection and 16% with COVID-19 vaccination. However, clinical features and functional outcomes of C-GBS and NC-GBS cases are similar.

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“…C-reactive protein (CRP), procalcitonin (PCT), fibrinogen, and ferritin are positive acute-phase reactants because their expression is increased during inflammation. 15 Since the amount of proteins such as albumin and transferrin decreases during inflammation, these are called negative acute-phase reactants. 15 In systemic inflammation, CRP is secreted from the liver, and its level rises rapidly.…”

Section: Introductionmentioning

confidence: 99%

“… 15 Since the amount of proteins such as albumin and transferrin decreases during inflammation, these are called negative acute-phase reactants. 15 In systemic inflammation, CRP is secreted from the liver, and its level rises rapidly. C-reactive protein is used to follow many disease progressions as well as COVID-19 infections.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 Infection and Candidate Biomarkers

Uzunçakmak¹

2023

Eurasian J Med

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Severe acute respiratory syndrome coronavirus 2 is a virus that can still infect individuals and whose deadly effects continue despite the current vaccines and drugs. Since 2019, many studies on the pathogenesis of the disease have been completed and continue to be done. In addition to the diagnosis and treatment of the disease, many molecules that can be markers of the disease have been investigated. In the early stages of the pandemic, many nonspecific and infection-related laboratory findings and chest computed tomography were used to obtain information about the diagnosis of the disease. The more individual molecules became associated with the disease yet. The purpose of this review is to summarize the impact and role of many molecules associated with coronavirus disease-2019 infection that have been previously used and newly revealed. Numerous studies are summarized in this review. The obtained data show that previously used laboratory findings and new potential biomarkers are not specific to the disease. New potential biomarkers have been associated with the severity of the disease itself, as can be seen with lung imaging and even with routine laboratory findings. One of the important points that are seen frequently in studies is that the effectiveness of these molecules has been shown not only in coronavirus disease-2019 infection but also in many other diseases. This removes the pathogenesis of the disease from being a unique mechanism created by the Severe acute respiratory syndrome coronavirus 2 and provides a general perspective formed by viral or bacterial infections. However, there are still many molecular changes that need to be investigated. Future studies will continue to update themselves with the mutations of the virus.

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Relationship Between Acute Phase Reactants and Disability in Guillian-Barré Syndrome During the COVID-19 Pandemic

Cited by 3 publications

References 30 publications

The characteristics of Guillain–Barre syndrome in children in pre‐COVID‐19 and during the COVID‐19 pandemic: A cross‐sectional study

The characteristics of Guillain–Barre syndrome in children in pre‐COVID‐19 and during the COVID‐19 pandemic: A cross‐sectional study

Assessment of the relationship between COVID -19 and Guillain Barre syndrome: a single center pandemic experience

SARS-CoV-2 Infection and Candidate Biomarkers

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