Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island

Abstract

Essential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The objective of this study was to evaluate the association of ADD1 (Gly460Trp) gene polymorphism with the EH risk in a population from Madeira Island.A case-control study with 1614 individuals of Caucasian origin was performed, including 817 individuals with EH and 797 controls. Cases and controls were matched for sex and age, by frequency-matching method. All participants collected blood for biochemical and genotypic analysis for the Gly460Trp polymorphism. We further investigated which variables were independently associated to EH, and, consequently, analyzed their interactions.In our study, we found a significant association between the ADD1 gene polymorphism and EH (odds ratio 2.484, P = .01). This association remained statistically significant after the multivariate analysis (odds ratio 2.548, P = .02).The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with EH risk in our population. The knowledge of genetic polymorphisms associated with EH is of paramount importance because it leads to a better understanding of the etiology and pathophysiology of this pathology.

The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population

“…The authors concluded that ADD1 Gly460Trp-polymorphism is an independent genetic marker for AH occurrence in the Japanese population [ 12 ]. An association between T allele and AH development was revealed among Russians [ 15 ], Chinese [ 14 ], Japanese [ 11 ], inhabitants of Madeira [ 18 ], Tunisia [ 16 ], North Africa [ 13 ], and Asian population [ 17 ]. The results we have obtained also indicate an association between ADD1 Gly460Trp-polymorphism and AH occurrence in Ukrainians and demonstrate the higher T allele frequency in patients with salt-sensitive AH.…”

“…A number of population studies revealed an association between the Gly460Trp T allele ( ADD1 gene) and AH development [ 10 – 18 ]; however, in others, this link is absent [ 19 – 22 ]. It should be noted that data on the association between ADD1 Gly460Trp-polymorphism and the AH occurrence remain controversial and demonstrate the interpopulation differences in the association of gene polymorphic variants with the risk of AH development.…”

Single nucleotide polymorphism rs4961 in the adducin 1 gene is not associated with gastric cancer or preneoplastic cancer lesions

“…Genetic variation in several genes may account for the increased salt sensitivity of certain individuals ( 12 ). Moreover, when regarding the predisposition towards GC, individuals who are not sensitive to salt may ingest larger amounts of salt than necessary or normal when attempting to taste salt in food, thus increasing the likelihood of developing GC.…”