Relationship between adjuvant activity and amphipathic structure of soyasaponins

Oda, Kazuhiro; Matsuda, Hisashi; Murakami, Toshiyuki; Katayama, Shigeji; Ohgitani, Toshiaki; Yoshikawa, Masayuki

doi:10.1016/s0264-410x(02)00739-9

Cited by 87 publications

(68 citation statements)

References 27 publications

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“…They possess certain adjuvant activities, due to their structural features of sugar chain(s), its length, and hydrophilic and lipophilic properties [236]. Therefore, their adjuvant activity can be further modified by structural modifications such as GPI-0100 [237].…”

Section: Saponins and Qs21mentioning

confidence: 99%

Selection of Adjuvants for Enhanced Vaccine Potency

Wang¹,

Singh²

2011

WJV

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Section: Saponins and Qs21mentioning

confidence: 99%

Selection of Adjuvants for Enhanced Vaccine Potency

Wang¹,

Singh²

2011

WJV

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“…Saponins contain a steroidal or triterpenoid aglycone to which one or more sugar chains are attached (Oda et al, 2003). These are found widely in the plant kingdom with the triterpenoid saponins predominant mostly in cultivated crops, while steroid saponins are common in plants used as herbs or for their health-promoting properties according to Fenwick et al(1991).…”

Section: Saponinsmentioning

confidence: 99%

“…Saponins from soybean have been separated into six (Khalil and El-Adawy, 1994) or eight (Oda et al, 2003) fractions of soyasapogenol and soyasaponins groups. Oda et al(2000; found that the soyasaponins exhibited high adjuvant activity while the soyasapogenol group exhibited low activity.…”

Section: Othersmentioning

confidence: 99%

Adjuvant effects of saponins on animal immune responses

Rajput

Xiao

et al. 2007

J. Zhejiang Univ. - Sci. B

223

149

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Abstract:Vaccines require optimal adjuvants including immunopotentiator and delivery systems to offer long term protection from infectious diseases in animals and man. Initially it was believed that adjuvants are responsible for promoting strong and sustainable antibody responses. Now it has been shown that adjuvants influence the isotype and avidity of antibody and also affect the properties of cell-mediated immunity. Mostly oil emulsions, lipopolysaccharides, polymers, saponins, liposomes, cytokines, ISCOMs (immunostimulating complexes), Freund's complete adjuvant, Freund's incomplete adjuvant, alums, bacterial toxins etc., are common adjuvants under investigation. Saponin based adjuvants have the ability to stimulate the cell mediated immune system as well as to enhance antibody production and have the advantage that only a low dose is needed for adjuvant activity. In the present study the importance of adjuvants, their role and the effect of saponin in immune system is reviewed.

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“…Secara umum, saponin memeliki efek hemolisis yang cukup besar. Namun, soyasaponin memiliki efek hemolisis yang kecil dibanding saponin dari sumber lainnya (Sun et al, 2009;Oda et al, 2003).…”

Section: Pendahuluanunclassified

SOYASAPONIN SEBAGAI ADJUVAN UNTUK MENINGKATKAN IMUNOGENISITAS VAKSIN INFLUENZA BERBASIS EPITOP M2e

Idar¹,

Subroto

Soemitro

2015

Chim. Nat. Acta

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Abstrak: Indonesia menempati urutan pertama di dunia dalam kasus infeksi flu burung. Vaksin flu burung yang beredar saat ini masih berbasis hemaglutinin (HA) dan Neuraminidase (NA) yang mudah mengalami mutasi. Untuk mengatasi hal tersebut, dikembangkan vaksin influenza universal yang berbasis epitop virus influenza yang lestari yaitu M2e. Namun diperlukan adjuvan untuk meningkatkan imunogenisitas M2e. Soyasaponin adalah salah satu jenis saponin yang berpotensi dikembangkan sebagai adjuvan. Dalam penelitian ini, digunakan epitop M2e yang telah dimodifikasi, M2e2-16-K-P25 dan soyasaponin I sebagai adjuvannya. Efektivitas vaksin diuji terhadap mencit galur BALB/c. Respon antibodi M2e yang dihasilkan pada serum mencit diukur dengan ELISA Berdasarkan penelitian ini, soyasaponin I terbukti dapat meningkatkan immunogenisitas epitop M2e2-16-K-P25 dengan cukup baik.

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Relationship between adjuvant activity and amphipathic structure of soyasaponins

Cited by 87 publications

References 27 publications

Selection of Adjuvants for Enhanced Vaccine Potency

Selection of Adjuvants for Enhanced Vaccine Potency

Adjuvant effects of saponins on animal immune responses

SOYASAPONIN SEBAGAI ADJUVAN UNTUK MENINGKATKAN IMUNOGENISITAS VAKSIN INFLUENZA BERBASIS EPITOP M2e

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