Prevalence of high-risk behaviors has become one of the most important concerns in nowadays society. Aim of this study is was investigation of assay high-risk behaviors and their relations with demographic characteristics in adolescents. This study was performed on 400 of high school adolescents that were selected by randomized classify method. Data were collected by using of questionnaire including individual-social characteristics questionnaire and high-risk behaviors scale in assault and battery, tobacco, high-risk physical and sexual relations, lack of exercise and law breaking domains and then were analyzed. Prevalence of high-risk behaviors was 28.7% in boys and 22.5% in girls. Significant difference was founded between general high-risk behaviors and tobacco; sexual high-risk behaviors and Acquired Immunodeficiency Syndrome (AIDS) behaviors, AIDS and law breaking domains in girls and boys also significant relationship was found between high-risk behaviors and some individual, family and social factors. Findings of this study could empowerment health systems in accurate planning for screening and counseling of high-risk behaviors.