Relationship between airflow limitation in response to upper airway negative pressure during wakefulness and obstructive sleep apnea severity

Lim, Jan; Alshaer, Hisham; Ghahjaverestan, Nasim Montazeri; Bradley, T. Douglas

doi:10.1007/s11325-023-02892-3

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…Another study investigated whether negative pressure (NP)–induced airflow alteration applied to participant’s upper airways during wakefulness was related to OSA severity [ 46 ]. While awake, for five full breaths, the 18 participants were orally twice exposed to − 3 cm H2O of NP.…”

Section: Methodsmentioning

confidence: 99%

“…Training area under curve (AUC) of receiver operating characteristics (ROC) was up to 99% with 91.7% sensitivity and 95.8% specificity [ 45 ] 29 with AHI < 5, 28 with 5 ≤ AHI < 15, 34 with 15 ≤ AHI < 30 and 64 with AHI > 30 Exhaled volume percentages at 200 ms and 500 ms were significantly lower in all OSA severity groups. At a threshold of AHI > 15, training AUC of ROC was up to 90% with 93.9% sensitivity and 74.1% specificity [ 46 ] 18 subjects with AHI values between 1.7 and 87.9 The relationship between ExpNPR and AHI remained robust, even when considering demographic factors commonly associated with AHI …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Obstructive sleep apnea detection during wakefulness: a comprehensive methodological review

Alqudah,

Elwali,

Kupiak

et al. 2024

Med Biol Eng Comput

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Obstructive sleep apnea (OSA) is a chronic condition affecting up to 1 billion people, globally. Despite this spread, OSA is still thought to be underdiagnosed. Lack of diagnosis is largely attributed to the high cost, resource-intensive, and time-consuming nature of existing diagnostic technologies during sleep. As individuals with OSA do not show many symptoms other than daytime sleepiness, predicting OSA while the individual is awake (wakefulness) is quite challenging. However, research especially in the last decade has shown promising results for quick and accurate methodologies to predict OSA during wakefulness. Furthermore, advances in machine learning algorithms offer new ways to analyze the measured data with more precision. With a widening research outlook, the present review compares methodologies for OSA screening during wakefulness, and recommendations are made for avenues of future research and study designs. Graphical abstract

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Obstructive sleep apnea detection during wakefulness: a comprehensive methodological review

Alqudah,

Elwali,

Kupiak

et al. 2024

Med Biol Eng Comput

View full text Add to dashboard Cite

show abstract

Diagnosis and Management of Obstructive Sleep Apnea: Updates and Review

Luong,

Lezama,

Khan

2024

JOHBM

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Obstructive sleep apnea (OSA) is a heterogenous disease process that cannot be adequately categorized by AHI alone. There is a significant prevalence of OSA in the general population with ongoing efforts to evaluate the risk factors contributing to OSA and its associated clinical implications. Only by improving our understanding of OSA can we advance our methods in the diagnosis and treatment of OSA. For this article, the authors reviewed keywords of obstructive sleep apnea diagnosis and therapy in the databases of Embase, Medline, and Medline ePub over the past 3 years, excluding any articles that only addressed sleep apnea in children under age 17 years. This review article is divided into three main sections. First, we will investigate the use of novel screening tools, biomarkers, anthropometric measurements, and novel wearable technologies that show promise in improving the diagnosis of OSA. There is mention of comorbid conditions seen in OSA patients since certain disease combinations can significantly worsen health and should raise our awareness to diagnose and manage those concomitant disorders. The second section will look at the current and developing treatment options for OSA. These include positive airway therapy (PAP), mandibular advancement device (MAD), exciting new findings in certain medications, orofacial myofunctional therapy (OMT), hypoglossal nerve stimulation therapy (HGNS), and other surgical options. We will conclude with a section reviewing the current Clinical Practice Guidelines for Diagnostic Testing in Adults with Obstructive Sleep Apnea from 2017, which strongly advises polysomnography (PSG) or home sleep apnea testing (HSAT), along with comprehensive sleep evaluation for uncomplicated patients with a clinical presentation of OSA.

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Relationship between airflow limitation in response to upper airway negative pressure during wakefulness and obstructive sleep apnea severity

Cited by 2 publications

References 43 publications

Obstructive sleep apnea detection during wakefulness: a comprehensive methodological review

Obstructive sleep apnea detection during wakefulness: a comprehensive methodological review

Diagnosis and Management of Obstructive Sleep Apnea: Updates and Review

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