Relationship between alcohol craving dimensions and features of comorbid mental health in an alcohol dependent sample

Cheng, Brandon; Coates, Jason M.; Gullo, Matthew J.; Feeney, Gerald F.X.; Kavanagh, David J.; Young, Ross McD.; Connor, Jason P.

doi:10.1016/j.addbeh.2021.107106

Cited by 9 publications

(3 citation statements)

References 32 publications

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“…Higher amounts of alcohol and a fivefold risk of developing a persistent AUD in the following years have been reported in people who drink to cope with anxiety symptoms [ 62 ]. Further, in AUD patients, comorbid anxiety is associated with higher craving, which in turn increases the risk of drinking relapse and overall worse outcomes [ 10 , 63 ]. Trazodone has proven beneficial effects on anxiety in MDD patients and has been widely used as an off-label treatment for generalized anxiety disorders [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Update on Pharmacological Treatment for Comorbid Major Depressive and Alcohol Use Disorders: The Role of Extended-release Trazodone

Nicola

Pepe

Panaccione

et al. 2023

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Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) are major public health concerns because of their high prevalence and clinical and functional severity. MDD and AUD commonly co-occur, but effective therapeutic approaches for comorbidity are still scarce. Available evidence on selective serotonin reuptake inhibitors and tricyclic antidepressants held mixed results, and further pharmacological categories have been less investigated. Trazodone is an approved antidepressant drug for adults and has shown efficacy on symptoms like anxiety and insomnia ob- served in AUD patients as well. Thus, this study aims to evaluate the effect of extended-release trazo- done on clinical and functional features in MDD + AUD subjects. Methods: One hundred MDD + AUD outpatients were retrospectively evaluated at 1, 3, and 6 months of treatment with extended-release trazodone (150-300 mg/day, flexibly dosed). Improvement in de- pressive symptoms was the primary outcome measure. Changes in anxiety, sleep, functioning, quality of life, clinical global severity, and alcohol craving were also investigated. Results: Trazodone reduced depressive symptoms (p < 0.001) with 54.5% remission at the endpoint. Similar improvements were observed in all secondary outcomes, including anxiety, sleep alterations, and craving (p < 0.001). Only mild side effects were reported and disappeared over time. Conclusion: Extended-release trazodone displayed good antidepressant properties in MDD + AUD patients, ameliorating overall symptomatology, functioning, and quality of life, with a good safety/ tolerability profile. Further, it significantly improved sleep disturbances and craving symptoms, which are associated with drinking relapse and worse outcomes. Therefore, trazodone might represent a promising pharmacological option for MDD + AUD patients.

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Section: Discussionmentioning

confidence: 99%

Update on Pharmacological Treatment for Comorbid Major Depressive and Alcohol Use Disorders: The Role of Extended-release Trazodone

Nicola

Pepe

Panaccione

et al. 2023

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“…a party) and relief craving (avoidance of unpleasant effects, such as withdrawal symptoms). Predominantly negative moods such as stress, anxiousness, anger or a depressive mood can trigger cravings [6,7,[14][15][16][17][18][19][20][21][22][23][24]. The affected person's location and environment have also been found to impact general cravings, e.g.…”

Section: Introductionmentioning

confidence: 99%

Analysis of addiction craving onset through natural language processing of the online forum Reddit

Kramer,

Groh,

Stüben

et al. 2024

PLoS ONE

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Aims Alcohol cravings are considered a major factor in relapse among individuals with alcohol use disorder (AUD). This study aims to investigate the frequency and triggers of cravings in the daily lives of people with alcohol-related issues. Large amounts of data are analyzed with Artificial Intelligence (AI) methods to identify possible groupings and patterns. Methods For the analysis, posts from the online forum “stopdrinking” on the Reddit platform were used as the dataset from April 2017 to April 2022. The posts were filtered for craving content and processed using the word2vec method to map them into a multi-dimensional vector space. Statistical analyses were conducted to calculate the nature and frequency of craving contexts and triggers (location, time, social environment, and emotions) using word similarity scores. Additionally, the themes of the craving-related posts were semantically grouped using a Latent Dirichlet Allocation (LDA) topic model. The accuracy of the results was evaluated using two manually created test datasets. Results Approximately 16% of the forum posts discuss cravings. The number of craving-related posts decreases exponentially with the number of days since the author’s last alcoholic drink. The topic model confirms that the majority of posts involve individual factors and triggers of cravings. The context analysis aligns with previous craving trigger findings related to the social environment, locations and emotions. Strong semantic craving similarities were found for the emotions boredom, stress and the location airport. The results for each method were successfully validated on test datasets. Conclusions This exploratory approach is the first to analyze alcohol cravings in the daily lives of over 24,000 individuals, providing a foundation for further AI-based craving analyses. The analysis confirms commonly known craving triggers and even discovers new important craving contexts.

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“…According to Vinder-Caerols et al [ 6 ], it is believed that a high intake of alcoholic beverages may alter behavior either temporarily or permanently. On the other hand, a study conducted by Cheng et al [ 7 ] stated that higher stress and anxiety levels could increase alcohol cravings. The studies also showed that controlling specific predictors may cause an insignificant relationship between alcohol cravings and depression; this is in support of the study by Vinader-Caerols [ 6 ], that temporary alteration in behavior may exist once a person consumes alcohol but can still recover from the said addiction.…”

Section: Introductionmentioning

confidence: 99%

Application of Conjoint Analysis and 5Ps Marketing Mix in Identifying Customer Preference of Alcohol Consumption among Youths in the Philippines

Yandug

Ponce

Ong

2023

Foods

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Alcoholic beverages have long been one of the most popular commodities. They have been mass-produced worldwide because of their popularity and demand. On a survey by Statista in 2021, alcohol consumption is projected to increase in the Philippines. Thus, the popularity of numerous alcoholic beverages piqued the curiosity of consumers and researchers alike. This study used conjoint analysis that aims to have a better understanding of consumer preferences for alcohol consumption among youths. Additionally, the study considered the following attributes: (1) type of alcoholic beverage, (2) oral sensation, (3) flavor, (4) origin, (5) color, and (6) price. Results revealed that the product’s price is the most crucial attribute influencing consumer preferences by 26.311%, followed by the type of alcoholic beverage with an importance score of 26.237%. The least considered attribute is the product’s color, having an importance score of 7.790%. These were supported by two statistical tests, the Pearson’s Correlation Test and Kendall’s Tau Test, which both obtained a value higher than 0.8. Managerial implications were presented in the study to help provide strategies and development for alcoholic beverage distribution in the Philippines based on the findings of this study, which relate to young consumers.

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Relationship between alcohol craving dimensions and features of comorbid mental health in an alcohol dependent sample

Cited by 9 publications

References 32 publications

Update on Pharmacological Treatment for Comorbid Major Depressive and Alcohol Use Disorders: The Role of Extended-release Trazodone

Update on Pharmacological Treatment for Comorbid Major Depressive and Alcohol Use Disorders: The Role of Extended-release Trazodone

Analysis of addiction craving onset through natural language processing of the online forum Reddit

Application of Conjoint Analysis and 5Ps Marketing Mix in Identifying Customer Preference of Alcohol Consumption among Youths in the Philippines

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