Relationship between alignment and cartilage thickness in patients with non-traumatic and post-traumatic knee osteoarthritis

Robbins, Shawn M.; Abram, F.; Boily, Mathieu; Pelletier, Jean‐Pierre; Martel‐Pelletier, Johanne

doi:10.1016/j.joca.2019.01.002

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…The occurrence of OCD depends on age, gender, and environmental conditions. Although treating the defects using surgeries is promising, cartilage regeneration remains as a post-surgery complication because of its structural complexity and low metabolic performance [1,2]. Furthermore, the long-term healing period of internal articular cartilage demands new strategies for repairing cartilage without surgery [3].…”

Section: Introductionmentioning

confidence: 99%

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering

et al. 2020

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The lack of adequate blood/lymphatic vessels as well as low-potential articular cartilage regeneration underlines the necessity to search for alternative biomaterials. Owing to their unique features, such as reversible thermogelling behavior and tissue-like mechanical behavior, agarose-based biomaterials have played a key role in cartilage tissue repair. Accordingly, the need for fabricating novel highly efficient injectable agarose-based biomaterials as hydrogels for restoration of injured cartilage tissue has been recognized. In this review, the resources and conspicuous properties of the agarose-based biomaterials were reviewed. First, different types of signals together with their functionalities in the maintenance of cartilage homeostasis were explained. Then, various cellular signaling pathways and their significant role in cartilage tissue engineering were overviewed. Next, the molecular structure and its gelling behavior have been discussed. Eventually, the latest advancements, the lingering challenges, and future ahead of agarose derivatives from the cartilage regeneration perspective have been discussed.

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Section: Introductionmentioning

confidence: 99%

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering

et al. 2020

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“…Radiographic findings such as joint space narrowing and osteophytes were found to be predominantly in the medial compartment of the knee joint in patients with nontraumatic knee OA, whereas it was found to be evenly distributed between medial and lateral compartments in patient with posttraumatic knee OA 16 . Lastly, frontal plane knee kinetics during gait 20 and the relationship between knee alignment and cartilage thickness differ between patients with and nontraumatic and posttraumatic medial compartment knee OA 21 . Therefore, differences in structural OA‐related changes and knee mechanics exist between patients with nontraumatic and posttraumatic knee OA.…”

Section: Introductionmentioning

confidence: 93%

“…Exclusion criteria included knee trauma or surgery within the last 12 months, history of joint arthroplasty in the lower extremities, neurological conditions (e.g., previous stroke), severe cardiovascular conditions (e.g., angina pectoris), or any other conditions affecting gait. Participants were part of an ongoing longitudinal study, 21,23 and all available participants were analyzed for the current study. Participants provided written, informed consent before enrollment.…”

Section: Participantsmentioning

confidence: 99%

“…16 Lastly, frontal plane knee kinetics during gait 20 and the relationship between knee alignment and cartilage thickness differ between patients with and nontraumatic and posttraumatic medial compartment knee OA. 21 Therefore, differences in structural OA-related changes and knee mechanics exist between patients with nontraumatic and posttraumatic knee OA.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between knee loading during gait and cartilage thickness in nontraumatic and posttraumatic knee osteoarthritis

Teoli

Cloutier-Gendron

et al. 2021

Journal Orthopaedic Research

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The relationship between knee moments and markers of knee osteoarthritis progression has not been examined in different knee osteoarthritis subtypes. The objective was to examine relationships between external knee moments during gait and tibiofemoral cartilage thickness in patients with nontraumatic and posttraumatic knee osteoarthritis. For this cross‐sectional study, participants with knee osteoarthritis were classified into two groups: nontraumatic (n = 22; mean age 60 years) and posttraumatic (n = 19; mean age 56 years, history of anterior cruciate ligament rupture). Gait data were collected with a three‐dimensional motion capture system sampled at 100 Hz and force plates sampled at 2000 Hz. External knee moments were calculated using inverse dynamics. Cartilage thickness was determined with magnetic resonance imaging (T1‐weighted, 3D sagittal gradient‐echo sequence). Linear regression analyses examined relationships between cartilage thickness with knee moments, group, and their interaction. A higher knee adduction moment impulse was negatively associated with medial to lateral cartilage thickness ratio (B = −1.97). This relationship differed between participants in the nontraumatic osteoarthritis group (r = −0.56) and posttraumatic osteoarthritis group (r = −0.30). A higher late stance knee extension moment was associated with greater medial femoral condyle cartilage thickness (B = −0.86) and medial to lateral cartilage thickness (B = −0.73). These relationships also differed between participants in the nontraumatic osteoarthritis group (r = −0.61 and r = −0.51, respectively) and posttraumatic osteoarthritis group (r = 0.10 and r = 0.25, respectively). Clinical Significance: The relationship between knee moments with tibiofemoral cartilage thickness differs between patients with nontraumatic and posttraumatic knee osteoarthritis. The potential influence of mechanical knee loading on articular cartilage may also differ between these subtypes.

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“…Knee osteoarthritis (OA) can be classified as nontraumatic in patients having no history of knee trauma or posttraumatic in patients who sustained a traumatic knee injury and subsequently developed knee OA. There are indications that the distribution of structural changes between the medial and lateral compartments of the joint is different between nontraumatic knee OA and posttraumatic knee OA [ 1 ]. One of the hallmarks of posttraumatic osteoarthritis (PTOA) is the irreversible degradation of articular cartilage after trauma and/or abnormal joint load, leading to joint dysfunction, pain, and movement limitation.…”

Section: Introductionmentioning

confidence: 99%

GSK3B Overexpression Alleviates Posttraumatic Osteoarthritis in Mice by Promoting DNMT1-Mediated Hypermethylation of NR4A3 Promoter

Sun

et al. 2022

Disease Markers

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Background. Glycogen synthase kinase 3β (GSK3B) is reported to be a protective factor for the degradation of chondrocytes by extracellular mechanisms. Nuclear receptor subfamily 4 group A member 3 (NR4A3) is a proinflammatory factor in osteoarthritis. Their regulation mechanism in posttraumatic osteoarthritis (PTOA) is not fully understood. Methods. GSK3B expression in the cartilage tissue of PTOA patients was analyzed by western blotting. IL-1β-induced chondrocytes were transfected with pcDNA-GSK3B, and then, the cell viability, apoptosis, expression of the chondrocyte extracellular matrix degradation-related genes MMP13, aggrecan, and type II collagen, and secretion of inflammatory factors TNF-α and IL-6 were detected. Co-IP was used to analyze the interaction between GSK3B and DNMT1. Ch-IP and methylation-specific PCR assays were used for methylation. Also, cells were transfected with pcDNA-GSK3B or together with pcDNA-NR4A3, as well as transfected with si-NR4A3, and then, cell functions were tested. Then, the mice subjected to destabilization of medial meniscus (DMM) surgery were intra-articular injected with 100 μL of the following adeno-related virus vectors (empty vector, Ad-GSK3B, scrambled shRNA, and sh-NR4A3), respectively, and the virus titer was 2 × 10 8 TU / mL . Cartilage integrity was evaluated by safranin O/fast green staining, HE staining, and Osteoarthritis Research Society International (OARSI) score. Results. The expression of GSK3B protein was downregulated in PTOA patients. GSK3B overexpression alleviated IL-1β-induced chondrocyte apoptosis and extracellular matrix degradation, as well as cartilage mineralization in PTOA model mice. NR4A3 overexpression reversed the effect of GSK3B on IL-1β-induced chondrocyte functions. GSK3B could recruit DNMT1 to the NR4A3 promoter region to promote the methylation of NR4A3 and inhibit the expression of NR4A3 protein. Similarly, NR4A3 interference alleviated cartilage degradation under stimulating conditions by inhibiting the activation of the JAK2/STAT3 signaling pathway. Conclusion. GSK3B recruits DNMT1 to the NR4A3 promoter region and inhibits the activation of the NR4A3-mediated JAK2/STAT3 signaling pathway, thereby alleviating PTOA.

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Relationship between alignment and cartilage thickness in patients with non-traumatic and post-traumatic knee osteoarthritis

Cited by 7 publications

References 20 publications

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering

The relationship between knee loading during gait and cartilage thickness in nontraumatic and posttraumatic knee osteoarthritis

GSK3B Overexpression Alleviates Posttraumatic Osteoarthritis in Mice by Promoting DNMT1-Mediated Hypermethylation of NR4A3 Promoter

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