Relationship Between Anatomical and Functional Assessments of Coronary Artery Stenosis

Severity of morphological lesion complexity affects fractional flow reserve in intermediate coronary stenosis

“…In addition to QCA parameters, our results showed that particular morphological lesion characteristics, including eccentricity, irregularity, or bifurcation, were associated with significantly lower FFR values relative to those of lesions without these characteristics. As the coronary pressure gradient is determined by the flow velocity and the separation and friction coefficients in a stenotic lesion are based on Bernoulli principals [27,28], these morphological factors could reduce the FFR value by producing a greater flow resistance and fluid energy loss consequent to friction, separation, and turbulence.…”