Relationship Between Aneurysm Volume and Histologic Healing after Coil Embolization in Elastase-Induced Aneurysms: A Retrospective Study

Ding, Yong Hong; Dai, Daying; Kadirvel, Ramanathan; Lewis, Daniel C.; Cloft, Harry J.; Kallmes, David F.

doi:10.3174/ajnr.a0752

Cited by 28 publications

(23 citation statements)

References 14 publications

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“…We found a significant relationship between aneurysm volume and recurrence; as previously demonstrated, aneurysms with large volumes (>600 mm 3 ) had a higher incidence of recurrence than those with small volumes. Ding et al 18 analyzed data on aneurysm volume and histologic healing after coil embolization in a rabbit elastase induced aneurysm model. The authors showed that complete thrombus organization within the aneurysms cavity and endothelium lining the neointima across the neck occurred more frequently in smaller aneurysms than in larger aneurysms.…”

Section: Discussionmentioning

confidence: 99%

Endovascular treatment of intracranial aneurysms with detachable coils: correlation between aneurysm volume, packing, and angiographic recurrence

Zheng

Ren

et al. 2013

J NeuroIntervent Surg

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Section: Discussionmentioning

confidence: 99%

Endovascular treatment of intracranial aneurysms with detachable coils: correlation between aneurysm volume, packing, and angiographic recurrence

Zheng

Ren

et al. 2013

J NeuroIntervent Surg

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“…Embolization of aneurysms was performed with platinum coils, as previously described, by the same author who created them ( 18 ). High rates of volumetric occlusion, typically defi ned as greater than 25%, have been associated not only with low recurrence rates clinically ( 19 ) but also with robust histologic healing in experimental aneurysm models ( 13 ). Conversely, low volumetric occlusion rates, less than 20%, are associated with frequent recanalization and poor healing.…”

Section: Molecular Imaging: Gene Expression In Healed Aneurysms Aftermentioning

confidence: 99%

“…In animal models ( 13 ) and in clinical practice ( 14 ), the durability of aneurysm occlusion is superior in densely packed aneurysms, as compared with loosely packed aneurysms. We hypothesized that experimental aneurysms could be used to probe, by using gene microarrays focused on proteins and other factors…”

Section: Embolization Proceduresmentioning

confidence: 99%

Differential Gene Expression in Well-healed and Poorly Healed Experimental Aneurysms after Coil Treatment

Kadirvel¹,

Ding²,

Dai³

et al. 2010

Radiology

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Purpose:To compare gene expression patterns between well-healed and poorly healed aneurysms following coil embolization in a rabbit model. Materials and Methods:The Institutional Animal Care and Use Committee approved all procedures before initiation of the study. Elastaseinduced, saccular aneurysms were created in rabbits and embolized by using platinum microcoils. Group 1 aneurysms were densely packed (volumetric packing density, . 30%) to achieve good healing, whereas group 2 aneurysms were loosely packed (volumetric packing density, , 20%), which yields poor healing. At 2 or 4 weeks after implantation, samples were harvested. RNA was isolated separately from the necks and domes of the aneurysms and analyzed by using a microarray containing 294 rabbit genes. Genes with signifi cant differences between groups ( P , .05; false discovery rate, , 0.1; fold change, Ն 1.2 and Յ 0.8) were considered differentially expressed.

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“…In the current study, we substantially enhanced the methodology compared with the prior study. First, we controlled packing density across groups, since previous reports have shown improved healing with higher packing density and poorer healing in the aneurysms with reduced packing densities 31. Second, we compared two methods of vitamin C medication delivery and confirmed that adequate levels were achieved.…”

Section: Discussionmentioning

confidence: 75%

Healing of saccular aneurysms following platinum coil embolization: lack of improved efficacy with vitamin C supplementation

Dai

Ding

Rezek

et al. 2012

J NeuroIntervent Surg

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BACKGROUND AND PURPOSE To test the hypothesis that systemic administration of vitamin C, through its action of stimulating collagen synthesis and cross-linking, would decrease the recurrence and improve the occlusion experimental aneurysms treated with platinum coil embolization. METHODS Nineteen experimental aneurysms in female rabbits were embolized with platinum coils (>30% packing density). The animals were divided into three groups: Group 1 (n=6) rabbits served as controls, Group 2 (n=5) rabbits were fed with a vitamin C-supplemented feed and Group 3 (n=8) rabbits were medicated with vitamin C pills. Digital subtraction angiography was used to evaluate stability after embolization. Subjects were euthanized at 12 weeks after coil implantation, and serum vitamin C levels were then measured. Histological samples were examined with a grading system (range, 0-12) based on the neck and dome features. Masson Trichrome staining was employed to evaluate collagen deposition. Parametric data were analyzed with one-way analysis of variance and non-parametric data were examined using a Kruskal-Wallis test. RESULTS There were no significant differences between groups in mean aneurysm size. Mean serum vitamin C concentration was significantly higher in Group 3 and Group 2 compared to Group 1, while vitamin C levels between Group 2 and Group 3 were statistically comparable. Coil compaction was noted in one of six subjects in Group 1 and three of eight subjects in Group 3. All the remaining aneurysms in the test and control groups showed stable occlusion. There were no significant differences in histological scores or collagen deposition among groups. CONCLUSION Vitamin C supplementation following platinum coil embolization does not demonstrate improvement of long-term occlusion rates of aneurysms.

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Relationship Between Aneurysm Volume and Histologic Healing after Coil Embolization in Elastase-Induced Aneurysms: A Retrospective Study

Abstract: BACKGROUND AND PURPOSE:There are, to our knowledge, no histologic data correlating aneurysm volume with histologic healing following coil embolization of aneurysms. We report a retrospective study comparing histologic outcome with aneurysm volume in elastase-induced aneurysms in rabbits.

Cited by 28 publications

References 14 publications

Endovascular treatment of intracranial aneurysms with detachable coils: correlation between aneurysm volume, packing, and angiographic recurrence

Endovascular treatment of intracranial aneurysms with detachable coils: correlation between aneurysm volume, packing, and angiographic recurrence

Differential Gene Expression in Well-healed and Poorly Healed Experimental Aneurysms after Coil Treatment

Healing of saccular aneurysms following platinum coil embolization: lack of improved efficacy with vitamin C supplementation

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