Relationship between antidepressants and glycolipids in the forced
swimming test in mice

Masuda, Yutaka; Ohnuma, S; Sugiyama, Toshihiro

doi:10.1358/mf.2000.22.9.802281

Cited by 4 publications

(1 citation statement)

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“…Concerning lipid profile, it has been established that mirtazapine and paroxetine (used in 6% of our study population) are associated with clinically significant increases in serum triglyceride level and LDL levels [ 48 , 49 ]. Fluoxetine (used in only 2% of our study population) had a favorable effect on both of the fractions of lipids, including the non-depressed diabetic population [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Improvement of Glycemic Control in Insulin-Dependent Diabetics with Depression by Concomitant Treatment with Antidepressants

et al. 2016

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BackgroundIt is still disputable whether negative effects of comorbid depression in diabetics can be diminished by successful treatment of depression. The primary aim of this study was to assess whether addition of antidepressants to existing insulin treatment would further improve glycemic control in these patients. A secondary objective was to assess whether such treatment impairs their lipid and inflammatory status.Material/MethodsTotal of 192 patients with poorly controlled diabetes (defined as HbA1c ≥8%) in the absence of any uncontrolled medical condition entered the 6-month run-in phase with optimization of diabetic therapy. Depression status was screened at the end of this phase by BDI-II depression testing. Patients with BDI-II ≥14 and psychiatric confirmation of depression (58 patients) entered the 6-month interventional phase with SSRI class antidepressants.ResultsFifty patients completed the study. During the run-in phase, HbA1c dropped from 10.0±1.8% to 8.5±1.2% (p<0.001), and during the interventional phase it dropped from 8.5±1.2% to 7.7±0.7% (p<0.001). BDI-II scores improved significantly from 30.4±13.2 to 23.5±11.0 (p=0.02) during the interventional phase. A positive linear correlation between improvement in depression scale and improvement in glycemic control was observed (R2=0.139, p=0.008). Lipid profile and inflammatory status did not change significantly during the interventional phase.ConclusionsPatients with poorly controlled diabetes and comorbid depression might benefit from screening and treatment of depression with SSRI antidepressants by achieving an incremental effect on glycoregulation. This therapy did not have any adverse effects on lipid profile or inflammatory status.

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Section: Discussionmentioning

confidence: 99%

Improvement of Glycemic Control in Insulin-Dependent Diabetics with Depression by Concomitant Treatment with Antidepressants

et al. 2016

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Fragment of human beta-fibrinogen induces a behavioral effect on mouse forced swimming

et al. 2002

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Humoral GalNAc.ALPHA.1-3GalNAc-Lipid Reactivity of Humans in Hypomanic State.

Masuda

Sugawara

Ohnuma

et al. 2002

Tohoku J. Exp. Med.

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A glycolipid having GalNAc alpha1-3GalNAc in the terminal increases a behavior climbing in a depression model, mouse forced swimming. Antidepressants, which sometimes induce hypomanic state in patients, increase the glycolipid and an anti-manic substance lithium decreases the glycolipid in mice. We detected the humoral GalNAc alpha1-3GalNAc-lipid reactivity of humans in different affective states. Although the reactivity was also showed in serums of the depression patients and the volunteers without affective disorders, the reactivity was remarkably increased in serums of hypomania patients. These strongly suggest that the humoral glycolipid increased the activities of the hypomania patients, but did not relate to the decrease of the activities in the depression patients.

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Relationship between antidepressants and glycolipids in the forced swimming test in mice

Cited by 4 publications

References 0 publications

Improvement of Glycemic Control in Insulin-Dependent Diabetics with Depression by Concomitant Treatment with Antidepressants

Improvement of Glycemic Control in Insulin-Dependent Diabetics with Depression by Concomitant Treatment with Antidepressants

Fragment of human beta-fibrinogen induces a behavioral effect on mouse forced swimming

Humoral GalNAc.ALPHA.1-3GalNAc-Lipid Reactivity of Humans in Hypomanic State.

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