2012
DOI: 10.1038/aja.2012.76
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Relationship between apoptotic markers in semen from fertile men and demographic, hormonal and seminal characteristics

Abstract: Apoptosis in the testis has two putative roles during normal spermatogenesis; limitation of the germ cell population to numbers that can be supported by the Sertoli cells, and, possibly, selective depletion of meiotic and postmeiotic abnormal germ cells. We investigated the demographic and biological correlates of the pro-apoptotic marker Fas and the anti-apoptotic marker Bcl-xL in sperm cells of fertile men. Six hundred and four men from Greenland, Poland and Ukraine were consecutively enrolled during their p… Show more

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“…6 Additionally, perfluorooctanoic acid (PFOA) exposure was positively correlated with a reduction in sperm DNA integrity in 199 subjects from Greenland. 7 An investigation of a pregnancy cohort in Denmark demonstrated a link between in utero exposure to PFCs and reduced semen quality in a group of 169 adult men. 8 Despite these data of correlations, we are still far from fully understanding the mechanism of this causal relationship; the current observations suggest the possibility of in utero perturbations by the chemicals.…”
Section: ■ Introductionmentioning
confidence: 99%
“…6 Additionally, perfluorooctanoic acid (PFOA) exposure was positively correlated with a reduction in sperm DNA integrity in 199 subjects from Greenland. 7 An investigation of a pregnancy cohort in Denmark demonstrated a link between in utero exposure to PFCs and reduced semen quality in a group of 169 adult men. 8 Despite these data of correlations, we are still far from fully understanding the mechanism of this causal relationship; the current observations suggest the possibility of in utero perturbations by the chemicals.…”
Section: ■ Introductionmentioning
confidence: 99%