Relationship between arterial stiffness and chronic kidney disease in patients with primary hypertension

Zuo, Junli; Hu, Yifei; Chang, Guili; Chu, Shao; Tan, Isabella; Butlin, Mark; Avolio, Alberto

doi:10.1038/s41371-019-0275-y

Cited by 14 publications

(14 citation statements)

References 35 publications

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“…Artery stiffness is of high incidence in hypertensive population. On the other hand, arterial stiffness can lead to microvascular complications and a series of organic damage, such as cerebrovascular diseases and renal damage [3,[25][26][27] . Moreover, research has found that arterial stiffness is positively correlated to the duration of diabetes mellitus in patients with hypertension [28] .…”

Section: Discussionmentioning

confidence: 99%

Association between insulin resistant surrogate index and arterial stiffness in hypertensive population: a five year follow-up cohort study

Wu¹,

Zhou²,

Zhang³

et al. 2020

Preprint

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Background Causal association between triglyceride-glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio with arterial stiffness remains unclear. This study aims to assess the effect of TyG index and TG/HDL-C ratio on the incidence of arterial stiffness in hypertensive population, and identify the susceptible subgroups. Methods This study enrolled 1201 hypertensive participants without arterial stiffness aged 18 or above in 2013 and 2014 as baseline. Physical examination and biochemical test including fasting blood glucose (FBG), TG, HDL-C were measured. The TyG index was denoted as ln[TG*FBG/2]. Incident arterial stiffness cases were confirmed during the following annual examination by brachial-ankle pulse wave velocity (baPWV, > 1800 cm/s), until December 31 of 2019. The Cox model was used to explore the association of TyG index and TG/HDL-C ratio with the arterial stiffness. Results During a mean follow-up of 5.09 years, 430 cases of arterial stiffness were confirmed. In the multivariate Cox model, the higher TyG index and TG/HDL-C ratio were positively associated with a higher risk of arterial stiffness (adjusted HR for per-unit increase: 1.39 and 1.08, P < 0.05). The adjusted HR (95% CI) comparing participants in the highest quartile versus lowest quartile of TyG and TG/HDL-C ratio were 1.51 (1.10–2.07) and 1.08 (1.01–1.15), respectively. This positive linear association of evaluated TyG index and TG/HDL-C ratio with arterial stiffness was confirmed using restricted cubic spline function. The observed association was stronger in subgroups with overweight, co-diabetes and poor blood pressure control (systolic pressure ≥ 140 mmHg or without anti-hypertension medication). Conclusion The elevated TyG index and TG/HDL-C ratio independently increased the future risk of arterial stiffness in hypertensive population. Monitoring TyG index and TG/HDL-C ratio deserves more attention in clinical practice, especially in the population with overweight, co-diabetes and poor blood pressure control.

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Section: Discussionmentioning

confidence: 99%

Association between insulin resistant surrogate index and arterial stiffness in hypertensive population: a five year follow-up cohort study

Wu¹,

Zhou²,

Zhang³

et al. 2020

Preprint

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“…Furthermore, the authors showed that dialysis patients had higher CIMT compared to stage III and V [31]. Another study indicated that HT patients with CKD had significantly higher CIMT compared to HT patients without CKD [17]. In contrast, Margekar et al found no significant differences in CIMT at the different stages of CKD [34].…”

Section: Discussionmentioning

confidence: 96%

“…PWV, a marker of arterial stiffness, has been shown to independently predict CVD mortality/mortality in end-stage renal failure patients [21]. It was reported that eGFR is negatively correlated with arterial stiffness, and increased PWV could predict the presence of CKD [17]. Reduced arterial stiffness improved life expectancy in end-stage renal failure patients regardless of blood pressure status [22].…”

Section: Discussionmentioning

confidence: 99%

“…CIMT has been linked to cardiovascular events and mortality in CKD patients [16]. Zuo et al showed that hypertensive CKD subjects with hypertension had augmented CIMT in comparison with non-CKD hypertensive patients [17]. Another study described that there was a negative correlation between CIMT and estimated glomerular filtration rate (eGFR) [16].…”

Section: Introductionmentioning

confidence: 99%

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The Association of Glomerular Filtration Rate With Echocardiographic Parameters in Chronic Kidney Disease

et al. 2021

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Background: Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in chronic kidney disease (CKD) patients. Aortic propagation velocity (APV), epicardial fat thickness (EFT) and carotid intima-media thickness (CIMT) measurements could provide additional information on assessing renal decline in CKD patients. The study aimed to evaluate EFT, AVP and CIMT in CKD patients and then investigate the association among those parameters. Methods: A total of 170 CKD consecutive subjects were enrolled in the study. Patients were divided into five groups according to their estimated glomerular filtration rate (eGFR) values. Each patient underwent complete transthoracic echocardiography examination. APV, EFT and CIMT were measured for analyses. A multivariate linear regression model was used for analysis to determine the independent predictors of eGFR. Results: The lowest APV was observed in stage IV-V, and the highest APV was observed in stage I-II (P < 0.001). Stage IV-V patients had the highest EFT and stage I-II patients had the lowest EFT (P < 0.001). Moreover, the lowest CIMT was observed in stage III, and the highest CIMT was observed in stage V (P < 0.001). eGFR was significantly and positively correlated with APV and negatively correlated with EFT and CIMT. In multivariate analyses, APV (odds ratio (OR): 0.289, P < 0.001), EFT (OR:-0.135, P < 0.001) and CIMT (OR:-0.388, P < 0.001) were independent predictors of eGFR. Conclusion: We found that APV decreased, and EFT and CIMT increased as CKD progress. The present study suggests that APV, EFT and CIMT might be incorporated with the examination of CKD patients in daily practice.

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“…CIMT is associated with cardiovascular events and mortality in CKD patients (16). Zuo et al presented that hypertensive patients with CKD had increased CIMT compared to non-CKD hypertensive patients (17). Another study described that there was a negative correlation between CIMT and estimated glomerular filtration rate (GFR) (16).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the relationship between glomerular filtration rate and aortic propagation velocity, epicardial fat thickness, and carotid intima-media thickness in chronic kidney disease patients

Özdemir¹,

Asoğlu

Aladağ

et al. 2020

Preprint

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Background: Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in chronic kidney disease (CKD) patients. Aortic propagation velocity (APV), epicardial fat thickness (EFT), and carotid intima-media thickness (CIMT) measurements could provide additional information on assessing renal decline in CKD patients. The study aimed to evaluate EFT, AVP, and CIMT in CKD patients and then investigate the association among those parameters. Methods and Results: A total of 170 CKD consecutive subjects were enrolled in the study. Patients were divided into five groups according to their GFR values. Each patient underwent complete transthoracic echocardiography examination. APV, EFT and CIMT were measured for analyses. A multivariate linear regression model was used for analysis to determine the independent predictors of GFR. The lowest APV was observed in stage IV-V, and the highest APV was observed in stage I-II (p<0.001). Stage IV-V patients had the highest EFT, and stage I-II patients had the lowest EFT (p<0.001). Moreover, the lowest CIMT was observed in stage III, and the highest APV was observed in stage V (p<0.001). GFR was significantly and positively correlated with APV and negatively correlated with EFT and CIMT. In multivariate analyses, APV (OR: 0.289, p<0.001), EFT (OR: -0.135, p<0.001) and CIMT (OR: -0.388, p<0.001) were independent predictors of GFR. Conclusion: We found that APV decreased, and EFT and CIMT increased as CKD progress. The present study suggests that APV, EFT, and CIMT might be incorporated with the examination of CKD patients in daily practice.

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Relationship between arterial stiffness and chronic kidney disease in patients with primary hypertension

Cited by 14 publications

References 35 publications

Association between insulin resistant surrogate index and arterial stiffness in hypertensive population: a five year follow-up cohort study

Association between insulin resistant surrogate index and arterial stiffness in hypertensive population: a five year follow-up cohort study

The Association of Glomerular Filtration Rate With Echocardiographic Parameters in Chronic Kidney Disease

Investigation of the relationship between glomerular filtration rate and aortic propagation velocity, epicardial fat thickness, and carotid intima-media thickness in chronic kidney disease patients

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