Relationship between asbestos bodies in sputum and the number of specimens

Sulotto, F; Capellaro, E; A, Chiesa; Villari, S.; S, Bontempi; Scansetti, G

doi:10.5271/sjweh.178

Cited by 13 publications

(8 citation statements)

References 6 publications

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“…The particular propensity of amphibole asbestos to form asbestos bodies has already been emphasised by various authors [17,18], and this is in line with the relationship observed in this study between the presence of asbestos bodies in sputum and a history of exposure to crocidolite. SULOTTO et al [12], however, did not report such a relationship. It is noteworthy that among the retired workers exposed to chrysotile only, 37% had asbestos bodies in the sputum.…”

Section: Mineralogical Sputum Examination: Sensitivity and Specificitymentioning

confidence: 74%

“…In previous reports, the frequency of detection of asbestos bodies in sputum differed from one occupational cohort to another: in highly exposed subjects, FARLEY et al [11] and MACDONALD et al [10] reported 35% and 29% of positive analyses, respectively. In vermiculite miners, SEBASTIEN et al [9] detected asbestos bodies in the sputum of 75% of workers; TESCHLER et al [3] reported positive asbestos body counts in 36.5% of occupationally exposed subjects and SULOTTO et al [12] reported a rate of 44.4%.…”

Section: Mineralogical Sputum Examination: Sensitivity and Specificitymentioning

confidence: 99%

See 1 more Smart Citation

Asbestos bodies in the sputum of asbestos workers: correlation with occupational exposure

Paris¹,

Galateau-Sallé²,

Creveuil³

et al. 2002

Eur Respir J

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A cross-sectional medical survey including collection of three consecutive sputum samples was carried out among 270 retired workers of a textile and friction materials factory, in order to investigate the relationship between asbestos body identification and asbestos exposure.The individual cumulative asbestos exposure, determined by means of a plant-specific job-exposure matrix based on asbestos air measurements in the workshops, proved to be heavy with a mean cumulative exposure of 217 fibres?mL -1 6yr. Macrophages and asbestos bodies were identified in sputum samples by light microscopy.The lung origin of the sputum, suggested by the presence of macrophages and/or asbestos bodies, was confirmed in 82.6% of subjects, and 53% of these samples were positive for asbestos bodies. The prevalence of asbestos bodies was not related to sex, smoking status or latency. Conversely, multivariate analysis showed a positive relationship with cumulative exposure, duration and intensity of exposure to asbestos, as well as age and time since retirement.These findings suggest that sputum analysis for asbestos bodies may remain a relevant and noninvasive marker of heavy occupational exposure to asbestos, even years after retirement. Owing to the new perspectives in lung cancer screening, it might contribute to the identification of high-risk subjects.

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Section: Mineralogical Sputum Examination: Sensitivity and Specificitymentioning

confidence: 74%

Section: Mineralogical Sputum Examination: Sensitivity and Specificitymentioning

confidence: 99%

Asbestos bodies in the sputum of asbestos workers: correlation with occupational exposure

Paris¹,

Galateau-Sallé²,

Creveuil³

et al. 2002

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…A high variation in AB counts has been demonstrated on sequential sputum samples, and analysis of pooled daily expectoration of sputum may yield fewer false-negative results [46,47], but even with five specimens the sensitivity remained quite low [48]. At least three studies comparing LT and sputum AB contents indicated that AB do not appear in sputum below a lung burden in the order of 1000 AB·g -1 wet lung or more (approximately 10,000 AB·g -1 dry lung) [46].…”

Section: Sputummentioning

confidence: 99%

Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. European Respiratory Society

Vuyst¹,

Karjalainen²,

Dumortier³

et al. 1998

Eur Respir J

156

107

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aaAsbestos comprises a group of six hydrated silicate minerals capable of forming very thin fibres: chrysotile, crocidolite, amosite, anthophyllite, tremolite and actinolite [1]. Chrysotile belongs to the serpentine group and the other five to the amphibole group of minerals. Chrysotile fibre bundles split easily and magnesium can be leached under weak acid conditions. These factors may contribute to the lower biopersistence of chrysotile in the lungs.

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“…The examination of sputum is a noninvasive method to study particulate burden and inflammatory processes in the lung. Researchers have studied the relevance of asbestos bodies in spontaneous sputum production [8,9]. In a study, a comparison of BAL and IS specimens yielded similar quantitative and qualitative results [10].…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of induced sputum and bronchoalveolar lavage fluid (BALF) profile in asbestos exposed workers

Alexopoulos

Bouros

Dimadi

et al. 2011

Journal of Occupational Medicine and Toxicology

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BackgroundBiological monitoring of healthy workers exposed to hazardous dusts lack validated screening tools. Induced sputum (IS) cellular profile was compared with bronchoalveolar lavage fluid (BALF) profile in asbestos exposed workers in order to assess its usefulness in monitoring workers exposed to asbestos for a long period of time.MethodsIS and BALF analysis was performed in 39 workers of a car brakes and clutches factory that uses chrysotile asbestos. Selection criteria were an employment history of > 15 years and the absence of a diagnosis of pneumonoconiosis. The type of cells, the existence of dust cells, of iron laden macrophages and of asbestos bodies were assessed and compared between IS and BALF samples.Results35 IS samples (90%) had dust cells, 34 (87%) iron laden macrophages and in 8 samples (21%) asbestos bodies were found. In most samples neutrophils were dominated. Samples with asbestos bodies (ABs) had significantly higher lymphocytes and lower neutrophils count compared with the samples without ABs. Macrophages and neutrophils in IS and BALF exhibited significant inter-relations (Spearman's rho: 0.26-0.29, p < 0.05) while IS lymphocytes count showed an inverse relation with BALF neutrophils (Spearman's rho: -0.36). Neutrophils and dust cells were highly correlated between the samples (Spearman's rho: 0.35, p < 0.05) while IS dust cells and lymphocytes were inversely related (Spearman's rho: -0.36, p < 0.05). More years of employment in the company was related with more neutrophils (Spearman's rho: 0.26) and less lymphocytes (Spearman's rho: -0.33) count. In multivariate analysis the presence of AB in IS samples was strongly related to the presence of asbestos bodies and lymphocytes count in BALF samples.ConclusionsIS and BALF analysis showed a similar cellular profile indicating that IS sampling in exposed workers to asbestos as a less invasive and expensive method may be useful in providing an insight both for inhalation of dusts and inflammatory processes in the lung.

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Relationship between asbestos bodies in sputum and the number of specimens

Cited by 13 publications

References 6 publications

Asbestos bodies in the sputum of asbestos workers: correlation with occupational exposure

Asbestos bodies in the sputum of asbestos workers: correlation with occupational exposure

Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. European Respiratory Society

Comparative analysis of induced sputum and bronchoalveolar lavage fluid (BALF) profile in asbestos exposed workers

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