Relationship between ascorbic acid and cell division

5 Digging out Roots: Pattern Formation, Cell Division, and Morphogenesis in Plants

“…The low levels of AA in the quiescent center appear to be actively maintained by the local high level of ascorbate oxidase, suggesting a function for AA in the regulation of cell division. This is consistent with the observation that cells in the quiescent center have extended G1 phases (Clowes, 1975) and that AA may be necessary for G1/S transition in the cell cycle (Liso et al, 1984(Liso et al, , 1988Citterio et al, 1994). Taken together, these results suggest a mechanism that operates to lower the GSH and AA pools or shift their redox balance not only in the quiescent center but also in proximally located cells of the meristem to restrict the extent of the meristematic zone.…”

Ascorbate Biosynthesis in Arabidopsis Cell Suspension Culture

“…On average, an 8-d-old 400-L aliquot of cell culture contained 48.7 mg fresh weight of cells at the start of the experiment and 56.1 mg after 24 h (48.7 mg fresh weight of cells corresponds approximately to 1.07 ϫ 10 6 cells). Although l-AA has been implicated in the stimulation of cell division (Liso et al, 1984(Liso et al, , 1988Arrigoni, 1994;Citterio et al, 1994;Kerk and Feldman, 1995), over the time course of these experiments we were unable to measure any significant increase in cell numbers relative to controls with substrates that stimulated l-AA biosynthesis.…”

“…Lycorine is a pyrrolophenanthridine alkaloid that is thought to specifically inhibit l-AA biosynthesis at concentrations as low as 1 m (Arrigoni et al, 1975;Liso et al, 1984) by direct interaction between the alkaloid and GLDH (De Gara et al, 1994;Arrigoni et al, 1997). However, lycorine is also known to be strongly antimitotic, to interfere with ribosomal peptidyl transferase activity (Kukhanova et al, 1983), and to at least partially inhibit mtDNA and RNA synthesis in yeast (Del Giudice et al, 1984;Massardo et al, 1994).…”

Effect of ascorbic acid and glutathione on somatic embryogenesis induction in Picea pungens Engelmann

“…АК и ВГ влияли на размеры и коли-чество соматических зародышей. Внесение АК стимулировало частоту формирования ЭСМ при Turczaninowia 20 (3): 27-35 (2017) инициации соматического эмбриогенеза и спо-собствовало развитию глобулярных зародышей на этапе пролиферации, что, возможно, связано со стимулирующим действием этого антиок-сиданта на процессы клеточной пролиферации (Liso et al, 1984). Однако количество сомати-ческих эмбриоидов в ЭСМ снижалось в 1,5-2,5 раза по сравнению с контролем.…”