Relationship between asthma and gastro‐oesophageal reflux: Significance of endoscopic grade of reflux oesophagitis in adult asthmatics

Nakase, Hiroshi; Itani, Toshinao; Mimura, Jun; Kawasaki, Toshihiko; Komori, Hideshi; Tomioka, Haruaki; Chiba, Tsutomu

doi:10.1046/j.1440-1746.1999.01939.x

Cited by 30 publications

(21 citation statements)

References 17 publications

(23 reference statements)

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“…Vagally mediated reflex and microaspiration worsens asthma, while autonomic nerve disturbance and the use of bronchodilators affect GERD. Ten papers [43,[140][141][142][143][144][145][146][147][148] identified an association between GERD and bronchial asthma, and most studies focused on the prevalence of GERD in asthmatics. Although the diagnostic criteria for GERD were different among these studies, the prevalence of GERD in asthmatics was high, ranging from 22.1 to 75.6% (Table 9).…”

Section: Bronchial Asthmamentioning

confidence: 99%

“…Several studies showed the efficacy of PPIs in the treatment of GERD and improvement of pulmonary function or asthma symptoms in asthmatic patients. PPIs attenuated GERD symptoms as well as asthma symptoms, but the efficacy of PPIs in improving pulmonary function remains controversial; improvement of peak expiratory flow was shown in three studies [142,143,145], but no change was observed in two studies [146,147]. A further large study is needed.…”

Section: Bronchial Asthmamentioning

confidence: 99%

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Epidemiology and clinical characteristics of GERD in the Japanese population

2009

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We reviewed articles on the epidemiology and clinical characteristics of gastroesophageal reflux disease (GERD) in Japan to clarify these features of GERD in this country. Although the definition of GERD depends on the individual study, the prevalence of GERD has been increasing since the end of the 1990s. The reasons for the increase in the prevalence of GERD may be due to increases in gastric acid secretion, a decrease in the Helicobacter pylori infection rate, more attention being paid to GERD, and advances in the concept of GERD. More than half of GERD patients had non-erosive reflux disease, and the majority (87%) of erosive esophagitis was mild type, such as Los Angeles classification grade A and grade B. There were several identified risk factors, such as older age, obesity, and hiatal hernia. In particular, mild gastric atrophy and absence of H. pylori infection influence the characteristics of GERD in the Japanese population. We also discuss GERD in the elderly; asymptomatic GERD; the natural history of GERD; and associations between GERD and peptic ulcer disease and H. pylori eradication. We examined the prevalence of GERD in patients with specific diseases, and found a higher prevalence of GERD, compared with that in the general population, in patients with diabetes mellitus, those with obstructive sleep apnea syndrome, and those with bronchial asthma. We provide a comprehensive review of GERD in the Japanese population and raise several clinical issues.

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Section: Bronchial Asthmamentioning

confidence: 99%

Section: Bronchial Asthmamentioning

confidence: 99%

Epidemiology and clinical characteristics of GERD in the Japanese population

2009

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“…But it is widely thought to be much lower in Asian countries [2,3,6]. However, little data in Asia is available [3,10]. This case report may shed more light on the fact that the incidence of GERD may not be as low as it seems.…”

Section: Discussionmentioning

confidence: 77%

“…This case report may shed more light on the fact that the incidence of GERD may not be as low as it seems. In addition, an increased prevalence of GERD has been observed in both children and adults with asthma, and the association between GERD and pulmonary disease is further supported by the reduction or even disappearance of asthmatic symptoms after surgical or medical treatment of acid reflux [9][10][11]. Matyasova reported a group consisting of 86 patients with bronchial asthma of varying severity; after a three-month regular GERD therapy with PPIs and prokinetics, bronchial asthma therapy was not administered any more [6].…”

Section: Discussionmentioning

confidence: 99%

Not asthma, but GERD: case report

Wang

2007

Front. Med. China

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Asthma is a disorder of the lungs characterized by increased responsiveness of the airways, as manifested by episodes of wheezing and increased resistance to expiratory airflow because of varying degrees of smooth muscle contraction, edema of the mucosa, and mucus in the lumen of the bronchi and bronchioles. The stimuli vary widely and include antigens, infection, air pollutants, respiratory tract irrtants, exercise, and emotional factors. This condition is completely different from distress breathing because of laryngotracheal spasm. One of its causes is the gastric content reflux through the pharynx to the larynx because of gastroesophageal reflux disease (GERD), in addition to the typical human avian flu that may cause immediate suffocation by laryngospasm owing to acute larygotrachitis. A patient suffered from GERD without esophageal symptoms, which was diagnosed and treated as bronchial asthma during his five emergency admissions. The admissions were because of episodic attacks of severe air hunger owing to an extreme throat tightening. The patient was being treated for as long as two years. After the correct diagnosis was made and treatment of laporascopic fundaplication was performed, the longstanding "bronchial asthma", after all, completely disappeared. The concept of "not asthma, but GERD" seems undervalued, unappreciated, even misunderstood among patients with intractable asthma. Therefore, such a case is reported in detail, similar cases are mentioned briefly as well, and a mechanism responsible for GERD-originated larryngo-or laryngotracho-spasm is proposed.

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“…However, only few data from Asia are available. 13 The aim of our study was to evaluate the results of 24-h esophageal pH monitoring of asthmatics to determine the incidence of abnormal gastroesophageal reflux (GER) in asthmatic patients in Taiwan, a region with low GERD prevalence.…”

Section: Introductionmentioning

confidence: 99%