Relationship Between Asthma Control Test And The Improvement Of FEV1 In Treated Patients With Asthma

Kwon, Jae-Woo; Kim, Sae-Hoon; Kim, Tae‐Bum; Park, Heung-Woo; Chang, Yoon-Seok; Jang, An‐Soo; Cho, You Sook; Nahm, Dong-Ho; Park, Jung-Won; Yoon, Ho Joo; Cho, Youngjoo; Choi, Byoung Whui; Moon, Hee‐Bom; Cho, Sang Heon

doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5751

Cited by 2 publications

(4 citation statements)

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“…Six publications found strong and consistent correlations between improvement in ACT score and improvement in ACQ score [8][9][10][11][12][13], with five of the publications assessing the statistical significance of the correlations. All five of these reports found statistically significant Number of asthma exacerbations 10 2 26,27 (2) 26,27 8 17,22,23,28-32 (7) 22,23,[28][29][30][31][32] Lung function 17 8 3,15,27,33-37 (5 b ) 3,34-37 9 11,13,18,38-43 (7 b ) 11,13,[38][39][40]42,43 General HRQoL 7 0 (0) 7 [49][50][51][52][53][54][55] (5 b ) 49,50,[52][53][54] Asthma-related QoL 7 5 28,34,[44][45][46] (5) 28,34,44-46 2 47,48 (2) 47,48 Sleep quality 6 2 45,56 (2) 45,56 5 [56][57]…”

Section: Act Score and Asthma Symptom Controlmentioning

confidence: 97%

“…Ten studies reported on the relationship between improvement in ACT score and reduction in asthma exacerbations (Table 1) [17,22,23,[26][27][28][29][30][31][32].…”

Section: Act Score and Asthma Exacerbationsmentioning

confidence: 99%

“…Two of the studies tested for correlations between improvement in ACT score and reduction in asthma exacerbations, resulting in small but significant correlation coefficients of − 0.129 and − 0.349, respectively (p < 0.01) [26,27].…”

Section: Act Score and Asthma Exacerbationsmentioning

confidence: 99%

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Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review

et al. 2020

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Background: The Asthma Control Test (ACT) has been used to assess asthma control in both clinical trials and clinical practice. However, the relationships between ACT score and other measures of asthma impact are not fully understood. Here, we evaluate how ACT scores relate to other clinical, patient-reported, or economic asthma outcomes. Methods: A targeted literature search of online databases and conference abstracts was performed. Data were extracted from articles reporting ACT score alongside one or more of: Asthma Control Questionnaire (ACQ) score; rescue medication use; exacerbations; lung function; health−/asthma-related quality of life (QoL); sleep quality; work and productivity; and healthcare resource use (HRU) and costs. Results: A total of 1653 publications were identified, 74 of which were included in the final analysis. Of these, 69 studies found that improvement in ACT score was related to improvement in outcome(s), either as correlation or by association. The level of evidence for each relationship differed widely between outcomes: substantial evidence was identified for relationships between ACT score and ACQ score, lung function, and asthma-related QoL; moderate evidence was obtained for relationships between ACT score and rescue medication use, exacerbations, sleep quality, and work and productivity; limited evidence was identified for relationships between ACT score and general health-related QoL, HRU, and healthcare costs. Conclusions: Findings of this review suggest that the ACT is an appropriate measure for overall asthma impact and support its use in clinical trial settings. GlaxoSmithKline plc. study number HO-17-18170.

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Section: Act Score and Asthma Symptom Controlmentioning

confidence: 97%

“…Ten studies reported on the relationship between improvement in ACT score and reduction in asthma exacerbations (Table 1) [17,22,23,[26][27][28][29][30][31][32].…”

Section: Act Score and Asthma Exacerbationsmentioning

confidence: 99%

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Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review

et al. 2020

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“…Recurrent exacerbations in the last 3 months are risk factors for further exacerbations which have a negative impact on asthma control [53]. Additionally, studies have shown that ACT can predict the risk of asthma exacerbations and that there is a negative correlation between the ACT score and the number of exacerbations [54, 55].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Severe Asthma Patients and Predictors of Asthma Control in the Swiss Severe Asthma Registry

Jaun,

Tröster,

Giezendanne

et al. 2023

Respiration

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Background: Asthma is a chronic airway disease, affecting over 300 million people worldwide. 5–10% of patients suffer from severe asthma and account for 50% of asthma-related financial burden. Availability of real-life data about the clinical course of severe asthma is insufficient. Objectives: The aims of this study were to characterize patients with severe asthma in Switzerland, enrolled in the Swiss Severe Asthma Registry (SSAR), and evaluate predictors for asthma control. Method: A descriptive characterisation of 278 patients was performed, who were prospectively enrolled in the registry until January 2022. Socio-demographic variables, comorbidities, diagnostic values, asthma treatment, and healthcare utilisation were evaluated. Groups of controlled and uncontrolled asthma according to the asthma control test were compared. Results: Forty-eight percent of patients were female and the mean age was 55.8 years (range 13–87). The mean body mass index (BMI) was 27.4 kg/m2 (±6). 10.8% of patients were current smokers. Allergic comorbidities occurred in 54.3% of patients, followed by chronic rhinosinusitis (46.4%) and nasal polyps (34.1%). According to the ACT score, 54.7% had well controlled, 16.2% partly controlled and 25.9% uncontrolled asthma. The most common inhalation therapy was combined inhaled corticosteroids/long-acting β2-agonists (78.8%). Biologics were administered to 81.7% of patients and 19.1% received oral steroids. The multivariable analysis indicated that treatment with biologics was positively associated with asthma control whereas higher BMI, oral steroids, exacerbations, and COPD were negative predictors for asthma control. Conclusion: Biologics are associated with improved control in severe asthma. Further studies are required to complete the picture of severe asthma in order to provide improved care for those patients.

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Relationship Between Asthma Control Test And The Improvement Of FEV1 In Treated Patients With Asthma

Cited by 2 publications

References 0 publications

Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review

Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review

Characteristics of Severe Asthma Patients and Predictors of Asthma Control in the Swiss Severe Asthma Registry

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