Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy

Polimorfismos genéticos da Alanina--Glioxilato Aminotransferase 2 (AGXT2) associados à disfunção erétil e marcadores de resposta aos iPDE-5

“…We clearly found that genotypes and haplotypes in this gene are associated with changes in ADMA plasma levels (Table 2 and 4, Figure 3). The association we found of rs18582 with plasma levels is consistent with previous results, where GG carriers had higher while A allele carriers had lower ADMA levels [21]. This is also consistent with a GWAS data with a very robust sample size [18].…”

“…This is also consistent with a GWAS data with a very robust sample size [18]. The association of DDAH1 haplotypes with ADMA levels (Figure 3) was not found previously [21]. Possibly, a higher number of participants here allowed us to observe this association.…”

“…We genotyped two single nucleotide polymorphisms (SNPs) of DDAH1, rs1554597 and rs18582, and two of DDAH2, rs805304 and rs805305, following procedures previously described [21]. Haplotype estimation was performed using PHASE v2.1 software…”

“…These enzymes are encoded by DDAH1 and DDAH2 genes, respectively, which have in their sequence important genetic polymorphisms that may alter the protein activity and expression [17; 18; 19; 20]. Recently, we have shown that these polymorphisms have an impact on Sildenafil responsiveness in vascular ED [21], which leads us to believe these could also increase risk for developing ED.…”

“…Pode-se destacar, por exemplo, a Tumescência Peniana Noturna, que consiste em avaliação da ereção durante o sono REM, esta é uma técnica bastante efetiva para diferenciação entre DE orgânica e DE psicogênica, pois, caso haja ereção noturna, há maior possibilidade de que o homem possua DE psicogênica 21 . Outro método conhecido para avaliação é o Doppler peniano, que consiste em avaliação pré e pós injeção intracarvenosa de drogas vasoativas 21 . E algumas outras técnicas, como alguns testes neurológicos, cavernosometria e arteriografia pudenda seletiva 22; 23 .…”