Relationship between asymptomatic rotavirus infection and jaundice in neonates: a retrospective study

Hwang, Nu Ri; Kim, Jin Kyu

doi:10.1186/s12887-018-1352-z

Cited by 6 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although studies on jaundice caused by bacterial infections, especially urinary tract infection, have progressed, studies on jaundice caused by viral infections are limited ( 28 – 30 ). Hwang and Kim ( 31 ) reported a relationship between asymptomatic RV infection and jaundice in newborns. However, in the current study, the association between RV-negative antigen and jaundice was statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Incidence, Clinical Characteristics, and Genotype Distribution of Rotavirus in a Neonatal Intensive Care Unit 5 Years After Introducing Rotavirus Vaccine

Yoon

Lim

Sohn³

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

BackgroundRotavirus (RV) is a common cause of viral gastroenteritis in children worldwide. We aimed to investigate the incidence, symptoms, and genotype of RV infection in a neonatal intensive care unit (NICU) in South Korea 5 years after the introduction of RV vaccination to evaluate its effect on newborn infants.MethodsA total of 431 fecal specimens were collected from patients admitted to NICU between April 20, 2012 and September 10, 2013. Enzyme-linked immunoassays were used to detect RV antigen. Nested multiplex polymerase chain reaction was used for genotyping.ResultsThe overall incidence of RV infection was 43.9% and was significantly higher in preterm infants, infants born in the study hospital, low birth weight infants, and cesarean births (P < 0.05). Symptoms of diarrhea, poor feeding, abdominal distension, and apnea were significantly higher in infants with RV infection than those without infection. RV infection gradually increased depending on infant care at home, postpartum clinic, or hospital (26.0, 45.1, and 60.2%, respectively; P = 0.000). The dominant RV genotype in the NICU was G4P[6] at 95.4%.ConclusionCurrent RV vaccines did not affect the incidence of RV infection in newborn and preterm infants in the NICU. Most RV-positive patients in the NICU had symptoms, and the incidence of RV infection was relatively higher in hospitals and postpartum clinics with group life than home. The dominant RV genotype was G4P[6] across study groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence, Clinical Characteristics, and Genotype Distribution of Rotavirus in a Neonatal Intensive Care Unit 5 Years After Introducing Rotavirus Vaccine

Yoon

Lim

Sohn³

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…Fever is known to be the most common symptom of rotavirus infection in newborns [ 8 , 9 , 13 ]. A recent study in Korea reported that rotavirus infection is frequently observed in newborns hospitalized for neonatal jaundice [ 14 ]. Rotavirus is the main neonatal gastroenteritis causing pathogen, and in this study, 40.4% of infants hospitalized for gastrointestinal system disease were rotavirus positive.…”

Section: Discussionmentioning

confidence: 99%

“…These findings suggest that the surveillance of symptomatic and asymptomatic newborns is imperative. However, previous studies have had limited data on the epidemiology of rotavirus outbreaks, including the prevalence of symptomatic newborns with jaundice, gastroenteritis, and seizures [1,[8][9][10][11]14].…”

Section: Introductionmentioning

confidence: 99%

Higher prevalence of rotavirus infection among out-born newborns transferred to a regional neonatal intensive care unit in Korea

Kim

Lee

et al. 2022

BMC Pediatr

View full text Add to dashboard Cite

Background Rotavirus is one of important pathogens which require infection control in nurseries and neonatal intensive care unit (NICU). Method We retrospectively reviewed 1,135 out-born newborns who were transferred to a regional tertiary NICU of Chungbuk National University Hospital between January 2012 and December 2016. We assessed the clinical characteristics of newborns based on the results of rotavirus surveillance tests. The prevalence of rotavirus was evaluated according to the year, month, and season. Results Among the 1,135 infants, 213 (18.8%) had positive results in the rotavirus surveillance test. The rotavirus positive group had a significantly higher gestational age, birth weight, and Apgar score. They also had a significantly higher rate of postpartum care centers when compared to the rotavirus negative group (45.5% vs. 12.6%, P < 0.001). Notably, the prevalence of rotavirus was significantly increased from 3.2 to 33.8% when infants were hospitalized 48 h after birth (P < 0.001). During the study period, there were no significant differences in the annual, monthly, or seasonal prevalence of rotavirus infection. Conclusion and discussion These findings suggest that more active screening for rotavirus infection is necessary, especially for out-born newborns admitted to NICUs 48 h after birth or hospitalized after using postpartum care centers in Korea.

show abstract

“…У новорожденных при ротавирусной инфекции редки тяжелые формы или летальный исход, заболевание может протекать в легкой форме (от 33 до 77 % больных младенцев) или бессимптомно. У инфицированных младенцев часто развивается желтуха [11,12].…”

unclassified

“…Союзом педиатров России в соответствии с поручением министра здравоохранения Российской Федерации подготовлены клинические рекомендации «Вакцинопрофилактика ротавирусной инфекции у детей» по применению зарегистрированной в Российской Федерации вакцины РотаТек ® (Вакцина для профилактики ротавирусной инфекции, пентавалентная, живая) производства Мерк Шарп и Доум Корп, США 12 .…”

unclassified

Rotavirus Epidemiology and Vaccination Tactics

Бондарев¹,

Шевцов²,

Indikova³

et al. 2019

Biopreparaty. Profilaktika, diagnostika, lechenie

View full text Add to dashboard Cite

Rotavirus infection is a widespread cause of severe gastroenteritis in children in low-income countries. Specific prophylaxis in young children has become the most important means of combating severe rotavirus gastroenteritis. The review presents current data on the molecular biology and genetic diversity of rotaviruses, interaction of viral proteins with host cell receptors, molecular aspects of infectivity and pathogenesis of rotavirus infection, and the development of immunity. It addresses a new approach to the epidemiology of rotavirus infection which regards it as a manageable infection, it illustrates the specificity of the epidemic process based on data gained from extensive experience in vaccination, and summarises relevant information on the introduction of rotavirus vaccines into the international healthcare practice. The paper summarises risks associated with the use of vaccines based on the analysis of WHO statistics, scientific publications on the epidemiology of rotavirus infection, and the results of vaccination. It analyses approaches of the competent authorities of some countries to the tactics of vaccination against rotavirus infection and the WHO stance on the use of existing vaccines for the prevention of rotavirus infection. A conclusion was made that it is necessary to further improve the tactics of vaccine prevention of rotavirus infection in Russia, to study the incidence of idiopathic intussusception, and to conduct further studies aimed at characterisation of existing and newly emerging genotypes of rotavirus.

show abstract

Relationship between asymptomatic rotavirus infection and jaundice in neonates: a retrospective study

Cited by 6 publications

References 21 publications

Incidence, Clinical Characteristics, and Genotype Distribution of Rotavirus in a Neonatal Intensive Care Unit 5 Years After Introducing Rotavirus Vaccine

Incidence, Clinical Characteristics, and Genotype Distribution of Rotavirus in a Neonatal Intensive Care Unit 5 Years After Introducing Rotavirus Vaccine

Higher prevalence of rotavirus infection among out-born newborns transferred to a regional neonatal intensive care unit in Korea

Rotavirus Epidemiology and Vaccination Tactics

Contact Info

Product

Resources

About