Relationship between bilateral temporal hypometabolism and EEG findings for mesial temporal lobe epilepsy: Analysis of 18F-FDG PET using SPM

Kim, Mi Ae; Heo, Kyoung; Choo, Min Kyung; Cho, Jung Hee; Park, Soo Chul; Lee, Jong Doo; Yun, Mijin; Park, Hae Jeong; Lee, Ki Young

doi:10.1016/j.seizure.2005.11.007

Cited by 46 publications

(46 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, hypometabolism that is not contiguous with, or distant from, the seizure focus, as opposed to perifocal hypometabolism, may be a negative prognostic factor in patients with both mesial temporal and neocortical electrographic seizure onsets (Wong et al, 2010, 2012). Bitemporal hypometabolism is associated with less-well-localized ictal epileptiform onset and may be a negative surgical prognostic indicator (Koutroumanidis et al, 2000; Joo et al, 2004; Kim et al, 2006). Patients with TLE and enlarged amygdala, but not MTS, have been reported to have ipsilateral hypometabolism (Lv et al, 2014).…”

Section: Positron Emission Tomographymentioning

confidence: 99%

Neuroimaging of epilepsy

Cendes

Theodore

Brinkmann

et al. 2016

Handbook of Clinical Neurology

158

135

View full text Add to dashboard Cite

Imaging is pivotal in the evaluation and management of patients with seizure disorders. Elegant structural neuroimaging with magnetic resonance imaging (MRI) may assist in determining the etiology of focal epilepsy and demonstrating the anatomical changes associated with seizure activity. The high diagnostic yield of MRI to identify the common pathological findings in individuals with focal seizures including mesial temporal sclerosis, vascular anomalies, low-grade glial neoplasms and malformations of cortical development has been demonstrated. Positron emission tomography (PET) is the most commonly performed interictal functional neuroimaging technique that may reveal a focal hypometabolic region concordant with seizure onset. Single photon emission computed tomography (SPECT) studies may assist performance of ictal neuroimaging in patients with pharmacoresistant focal epilepsy being considered for neurosurgical treatment. This chapter highlights neuroimaging developments and innovations, and provides a comprehensive overview of the imaging strategies used to improve the care and management of people with epilepsy.

show abstract

Section: Positron Emission Tomographymentioning

confidence: 99%

Neuroimaging of epilepsy

Cendes

Theodore

Brinkmann

et al. 2016

Handbook of Clinical Neurology

158

135

View full text Add to dashboard Cite

show abstract

“…Various other methods of PET data analysis, such as statistical parametric mapping (SPM, a voxel-based whole-brain analysis) or SPM extent analysis with asymmetry index, can also be used and can either increase the diagnostic yield of the PET scan or be helpful in equivocal cases ( Fig. 2) (6)(7)(8).…”

Section: Pet Imagingmentioning

confidence: 99%

The Role of Radionuclide Imaging in Epilepsy, Part 1: Sporadic Temporal and Extratemporal Lobe Epilepsy

Kumar

Chugani

2017

J. Nucl. Med. Technol.

View full text Add to dashboard Cite

CE credit: For CE credit, you can access the test for this article, as well as additional JNMT CE tests, online at https://www.snmmilearningcenter.org. Complete the test online no later than March 2020. Your online test will be scored immediately. You may make 3 attempts to pass the test and must answer 80% of the questions correctly to receive 1.0 CEH (Continuing Education Hour) credit. SNMMI members will have their CEH credit added to their VOICE transcript automatically; nonmembers will be able to print out a CE certificate upon successfully completing the test. The online test is free to SNMMI members; nonmembers must pay $15.00 by credit card when logging onto the website to take the test.Epilepsy is one of the most common yet diverse neurologic disorders, affecting almost 1%-2% of the population. Presently, radionuclide imaging such as PET and SPECT is not used in the primary diagnosis or evaluation of recent-onset epilepsy. However, it can play a unique and important role in certain specific situations, such as in noninvasive presurgical localization of epileptogenic brain regions in intractable-seizure patients being considered for epilepsy surgery. Radionuclide imaging can be particularly useful if MR imaging is either negative for lesions or shows several lesions of which only 1 or 2 are suspected to be epileptogenic and if electroencephalogram changes are equivocal or discordant with the structural imaging. Similarly, PET and SPECT can also be useful for evaluating the functional integrity of the rest of the brain and may provide useful information on the possible pathogenesis of the neurocognitive and behavioral abnormalities frequently observed in these patients. Present ly, nuclear medicine imaging such as PET and SPECT is not used in the primary diagnosis or evaluation of recent-onset epilepsy. However, it can play a unique and important role in certain specific situations. Almost a fourth of epileptic patients do not respond to medical treatment and develop intractable seizures. PET and SPECT can play a significant role in such patients by its ability to noninvasively localize epileptogenic brain regions before surgery. PET and SPECT do not play much of a role in localization when structural lesions visible on MR imaging are concordant with electrophysiologic and clinical data. However, many patients may have no visible brain lesion on CT or MR imaging, particularly children less than 2 y old, in whom some cortical malformations may be poorly visualized or missed completely because of immature myelination and poor gray matter-white matter differentiation. This limitation is significant, considering that these abnormalities constitute a major cause of epilepsy in children. Similarly, patients may have multiple structural lesions of which only 1 or 2 are epileptogenic, may have seizures arising far from the lesion, or may have discordant or inconclusive electroencephalogram findings. PET and SPECT can be useful in such cases by identifying the epileptogenic regions and guiding the subsequent subdur...

show abstract

“…Other semi-quantitative methods can be helpful to improve the diagnostic yield or aid in equivocal cases. Such methods include statistic parametric mapping (SPM) or SPM extend analysis with asymmetry index [56][57][58].…”

Section: Ictal Spectmentioning

confidence: 99%

Nuclear medicine in pediatric refractory epilepsy

Treves

Goodkind

Grant

2016

Clin Transl Imaging

View full text Add to dashboard Cite

The nuclear medicine procedures 99m Tc-ECD SPECT and 18 F-FDG PET play an important diagnostic role in children with refractory seizures. In select patients, surgical removal of epileptogenic cortex is a therapeutic option. Magnetic resonance imaging (MRI) is the principal imaging method used to identify which patients would benefit from the surgery. However, there are cases when MRI does not detect an abnormality (MRI-negative epilepsy). Under these, and other circumstances, functional nuclear medicine studies are helpful in the workup of these patients. A combination of nuclear medicine procedures with MRI and CT depicts functional-anatomic relationships and assists in the non-invasive localization of epileptogenic cortex. Information derived from these procedures is valuable in the selection of candidates for surgical resection. Timing of tracer administration in relation to imaging and monitoring the state of brain activation are essential for accurate interpretation. Ictal and interictal perfusion single photon computed tomography (SPECT), with digital subtraction and registration to MRI can define the region of ictal cortical hyperperfusion more clearly than separate image interpretation. Ictal SPECT is more sensitive than interictal positron emission computed tomography (PET) and interictal PET is more sensitive than interictal SPECT. Interictal SPECT and PET are easier to obtain than ictal SPECT, since they do not require coordination between seizure onset and tracer administration. When surface electrode grids or depth electrodes are planned, anatomic-functional images can assist in their anatomic positioning. The best results are obtained when the planning, execution and interpretation of nuclear medicine procedures are carried out with the support of a well-trained multidisciplinary team familiar with children and refractory seizures.

show abstract

Relationship between bilateral temporal hypometabolism and EEG findings for mesial temporal lobe epilepsy: Analysis of 18F-FDG PET using SPM

Cited by 46 publications

References 25 publications

Neuroimaging of epilepsy

Neuroimaging of epilepsy

The Role of Radionuclide Imaging in Epilepsy, Part 1: Sporadic Temporal and Extratemporal Lobe Epilepsy

Nuclear medicine in pediatric refractory epilepsy

Contact Info

Product

Resources

About