2009
DOI: 10.1159/000255462
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Relationship between Blood Levels of Heavy Metals and Parkinson’s Disease in China

Abstract: Background: Idiopathic Parkinson’s disease (PD) and the Parkinsonian syndrome caused by manganese (Mn) poisoning are known to be indistinguishable in terms of symptoms. We thus suspect that many patients who have accumulated Mn in the body in daily life are diagnosed as having idiopathic PD. We examined the relationship between PD and blood levels of heavy metals, and the influence of intake from food in a general population. Methods: The subjects comprised PD patients and sex- and age-matched controls recruit… Show more

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Cited by 64 publications
(47 citation statements)
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“…The controls were matched regarding sex and age (±3 years), had no PD or depression, but symptoms such as headache and dizziness. In the previous study with the same subjects, no differences were seen in intake of each metal, energy, protein, fat, carbohydrate or dietary fiber between the PD patients and the controls 12) . PD was diagnosed according to the criteria of the UK Parkinson's Disease Society Brain Bank 13) .…”
Section: Methodsmentioning
confidence: 70%
“…The controls were matched regarding sex and age (±3 years), had no PD or depression, but symptoms such as headache and dizziness. In the previous study with the same subjects, no differences were seen in intake of each metal, energy, protein, fat, carbohydrate or dietary fiber between the PD patients and the controls 12) . PD was diagnosed according to the criteria of the UK Parkinson's Disease Society Brain Bank 13) .…”
Section: Methodsmentioning
confidence: 70%
“…Urine Fe was also significantly higher in the PD patients without depression than in the controls. Because in our previous study, positive correlations between whole -blood Mn and serum Fe concentrations were seen in both PD patients and controls in a general population in China, a route of simultaneous intake of Mn and Fe should exist 6) . From these results excessive intake of Fe and accumulation of Mn seemed to be involved in the etiology of nondepressive PD.…”
Section: Discussionmentioning
confidence: 79%
“…Subjects were same as the previous report 6) and comprised 82 PD patients (47 men, 35 women ; mean (±standard deviation) age, 64.0±9.4 years) who had been patients for <3 years and were recruited from the outpatient clinic of Xiangfan No. 1 People's Hospital in Hubei, China between 2006 and 2008, and sex -and age -matched (±3 years) controls (n=82 ; mean age, 63.7±9.4 years) with no PD, but with symptoms such as headache and dizziness, who were recruited from the same outpatient clinic at the same time.…”
Section: Methodsmentioning
confidence: 99%
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“…Short-term Ni overexposure does not cause any health problem but long-term exposure may cause body weight loss, heart and liver damages, and skin irritation [14]. Ingestion of high Ni quantities may also cause cancer, respiratory arrest, abortions, allergies and cardiac arrest [45]. The phagocytosis of Ni compound particles and their dissolution in the nucleus induces an oxidative stress with genetic mutation [46].…”
Section: Heavy Metal Contamination Of Well Water In the Kipushi Mininmentioning
confidence: 99%